The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of 90Y and 177Lu isotopes for their subsequent use in nuclear medicine

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Аннотация

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.

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Авторлар туралы

A. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: adeptak92@mail.ru
Ресей, Moscow

J. Babenya

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

T. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

S. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

E. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

I. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

E. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

E. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

V. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

A. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

B. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow; Moscow

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2. Fig. 1. Sizes of the aggregates of the studied NA (a) and their ζ-potential (b) in HCl and NH3 solutions

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3. Fig. 2. The degree of sorption of 90Y by HA samples from aqueous solutions for 30 min (a) and the Y(III) form, calculated using CHEAQS [19] for the corresponding concentrations of reagents (b).

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4. Fig. 3. The degree of sorption of 90Y in 30 min and the size of HA aggregates depending on pH by TAN (a), ok-TAN (b), STP (c) and ok-STP (d) samples.

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5. Fig. 4. The degree of sorption of 177Lu by NA samples from aqueous solutions for 30 min (a) and Lu(III) forms calculated using CHEAQS [19] for the corresponding reagent concentrations (b).

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6. Fig. 5. The degree of sorption of 177Lu in 30 min and the size of HA aggregates depending on pH by TAN (a), STP (b) and ok-STP (c) samples.

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