Marine natural products: the long road to drug discovery

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Abstract

The collaboration between various research institutions in South Korea and G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC) in Russia started 30 years ago in 1993. Since then, we have been actively conducting marine biotechnology and pharmaceutical research. For nearly 20 years, this successful partnership has been led by the exceptional “conductor” Valentin Stonik, who has formed an exquisite harmony “orchestra” that we have named KORUS MUSIC (Korea-Russia collaboration for Marine Unlimitedre Sources for Innovation and Creation). The purpose of this review paper is to present the history of KORUS MUSIC and highlight the significant advances achieved through our joint research, and to outline plans for our future collaboration and joint efforts for the next 20 years. This article is a synthesis of science and poetry, of the history of friendly relations and dreams of a common future. It is dedicated to the 80th anniversary of Prof. Stonik, to the 60th anniversary of PIBOC and to the 30th anniversary of collaboration between the Korean and Russian scientists.

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About the authors

Hyoung Kyu Kim

Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center,
College of Medicine, Inje University; Department of Health Sciences and Technology, Graduate School of Inje University; Department of Physiology, College of Medicine, Inje University

Email: estrus74@gmail.com

доктор философии, профессор, профессор, профессор

Korea, Democratic People's Republic of, Busan, 614-735; Busan, 614-735; Busan, 614-735

Maria Victoria Faith V. Garcia

Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center,
College of Medicine, Inje University; Department of Health Sciences and Technology, Graduate School of Inje University

Email: victoriafaith.garcia@gmail.com

PhD, Post-doctoral Researcher, Post-doctoral Researcher

Korea, Democratic People's Republic of, Busan, 614-735; Busan, 614-735

Natalia M. Shepetova

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences

Author for correspondence.
Email: piboc@bk.ru

Assistant Director for International Relations

Korea, Democratic People's Republic of, Vladivostok, 690022

Jin Han

Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center,
College of Medicine, Inje University; Department of Health Sciences and Technology, Graduate School of Inje University; Department of Physiology, College of Medicine, Inje University

Email: phyhanj@inje.ac.kr

MD, PhD, Professor, Director, Professor, Professor

Korea, Democratic People's Republic of, Busan, 614-735; Busan, 614-735; Busan, 614-735

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Supplementary files

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2. Fig. 1. Prof. Valentin Stonik, Scientific Supervisor of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences

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3. Fig. 2. Timeline of KORUS publications, patents, and symposia through the years of research and friendship, 2005–2013. Images rendered by Biorender.com. Image usage is covered by BioRender’s Academic License Terms

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4. Fig. 3. Timeline of KORUS publications, patents, and symposia, 2014–2019. Images rendered by Biorender.com. Use of the images is subject to BioRender’s Academic License Terms

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5. Fig. 4. Distribution of publications by medical fields within the KORUS collaboration, 2014–2023

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6. Fig. 5. Prof. Stonik with the Korean Team including Dr. Kwak from Ajou University, working on marine triterpene glycosides

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7. Fig. 6. Dr. Hwayoung Yun of Pusan National University leads the physicochemical study to characterize Ech A

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8. Fig. 7. Echinochrome A is a versatile compound that has the potential to treat various diseases through multiple mechanisms and modes of treatment. Images rendered by Biorender.com. Use of the images is subject to BioRender’s Academic License Terms

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9. Fig. 8. Prof. Jee-Yeong Jeong of Kosin University College of Medicine led the hematology-focused research on Ech A

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10. Fig. 9. Dr. Byoung-Joo Lee of Pusan National University leads the study of Ech A application in otorhinolaryngology

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11. Fig. 10. Dr. Yinhua Zhang from Seoul National University leads Ech A studies focused on gynecology

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12. Fig. 11. Dr. Hyung-Sik Kim from Pusan National University leads research on gastroenterology

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13. Fig. 12. Prof. Hyoung Kyu Kim from Inje University investigated Ech A in Type 2 diabetic nephropathy

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14. Fig. 13. Prof. Woochul Chang of Pusan National University studies neurological benefits of Ech A

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15. Fig. 14. Dr. Jung Eun Seol of Inje University Busan Paik Hospital conducted research on photoaging and Ech A

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16. Fig. 15. Dr. Sang-Rae Lee from Inje University Busan Paik Hospital determined the effect of Ech A on melanogenesis

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17. Fig. 16. Prof. Jae-Ho Kim from Pusan National University determined the effects of Ech A in scleroderma

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18. Fig. 17. Prof. Sung Joon Kim investigated the effect of Ech A to ion channels in skin physiology

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19. Fig. 18. Prof. Jin Han of Inje University leads studies on Ech A related to cardiovascular disease and physiolog.

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20. Fig. 19. Dr. Sang Hong Baek from Seoul St. Mary’s Hospital of the Catholic University of Korea determined the effect of Ech A in cardiac progenitor cells

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21. Fig. 20. Dr. Chang Shin Yoon of Inje University studied the cardioprotective effect of SpD

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22. Fig. 21. Dr. Dae Yoon Seo lead the study on effect of Ech A in exercise capacity

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23. Fig. 22. Drs. Nikolay E. Nifantiev, Valentin A. Stonik and Tatyana N. Makarieva collaborated on NPS A

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