The problem of antibioticresistance. Secondary plant metabolites: antibacterial properties and application prospects

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Abstract

The review examines the problem of antibiotic resistance in the world and the causes of resistance, as well as a way to overcome this problem. One of the ways to overcome it is the use of secondary metabolites of plants with antibacterial properties. The review includes a large number of studies on the mechanisms of action of the antibacterial properties of secondary metabolites on bacterial cells and the possibility of combining them with various antibiotics to accumulate bactericidal and bacteriostatic effects and overcome the problem of resistance of microorganisms to antibiotics.

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About the authors

Askar A. Yerkin

Orenburg State University

Author for correspondence.
Email: askartlegenov12@gmail.com
ORCID iD: 0000-0003-3495-1608

Master’s Student

Russian Federation, Orenburg

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Supplementary files

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2. Fig. 1. Main mechanisms of bacterial resistance to antibiotics [24]

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3. Fig. 2. Model showing the switch of a bacterium from the cell wall to the L-form [28]

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4. Fig. 3. Inhibition zones under the action of piperine extract (in mm) [33]

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5. Fig. 4. Effect of berberine exposure on the morphology of E. coli cells: left - untreated cells, right - berberine-treated cells [38]

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