Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, Cd) in patients with two pathologies, lymphoma and leukemia, is considered.

Толық мәтін

Рұқсат жабық

Авторлар туралы

V. Trunova

Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University

Хат алмасуға жауапты Автор.
Email: valna-t@mail.ru
Ресей, Novosibirsk; Novosibirsk

T. Pospelova

Novosibirsk State Medical University

Email: valna-t@mail.ru
Ресей, Novosibirsk

M. Voytko

Novosibirsk State Medical University

Email: valna-t@mail.ru
Ресей, Novosibirsk

E. Krupovich

Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences

Email: valna-t@mail.ru
Ресей, Novosibirsk; Koltsovo

G. Soldatova

Novosibirsk State Medical University; Novosibirsk State University

Email: valna-t@mail.ru
Ресей, Novosibirsk; Novosibirsk

R. Kuzmin

Novosibirsk State Medical University

Email: valna-t@mail.ru
Ресей, Novosibirsk

K. Tsigulyov

Novosibirsk State Medical University

Email: valna-t@mail.ru
Ресей, Novosibirsk

Әдебиет тізімі

  1. Овечкина В.Н., Бондаренко С.Н., Морозова Е.В. и др. // Клиническая онкогематология. 2017. T. 10 № 3. C. 351. http://doi/org/10.21320/2500-2139-2017-10-3-351-357
  2. Schmid C., Labopin M., Nagler A., Niederwieser D., Castagna L., Tabrizi R., Stadler M., Kuball J., Cornelissen J., Vorlicek J., Socié G., Falda M., Vindeløv L., Ljungman P., Jackson G., Kröger N., Rank A., Polge E., Rocha V., Mohty M. // Blood. 2012. V. 119. № 6. P. 1599. http://doi/org/10.1182/blood-2011-08-375840
  3. Christopeit M., Kuss O., Finke J. et al. // J. Clin. Oncol. 2010. V. 31. № 26. P. 3259. http://doi/org/10.1200/JCO.2012.44.7961
  4. Kröger N., Bornhäuser M., Stelljes M., Pichlmeier U., Trenschel R., Schmid C., Arnold R., Martin H., Heinzelmann M., Wolschke C., Meyer R. G., Bethge W., Kobbe G., Ayuk F., Gökbuget N., Hölzer D., Zander A., Beelen D. // Bone Marrow Transplant. 2014. V. 50. № 12. P. 1503. http://doi/org/10.1038/bmt.2015.202
  5. Каприн А.Д., Старинский А.В., Шахзадовой А.О. Состояние онкологической помощи населению России в 2022 году. М.: МНИОИ им. П.А. Герцена, 2022. 239 с.
  6. Мирзаахмедова И.З. // Экономика и социум. 2022. Т. 3. № 2. С. 94.
  7. Мамедова А.А., Мочкин Н.Е., Саржевский В.О. и др. // Онкогематология. 2022. Т. 17. № 3. С. 40. http://doi/org/10.17650/1818-8346-2022-17-3-40-47
  8. Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. // Гематология и трансфузиология. 2018. Т. 63. № 1-S2. С. 5.
  9. Azin F., Raie R.M., Mahmoudi M.M. // Ecotoxicology and Environmental Safety. 1998. V. 39. № 3. P. 179.
  10. Guidotti T.L., McNamara J., Moses M.S. // Indian J. Med. Res. 2008. V. 128. № 4. P. 524.
  11. Cui Y., Vogt S., Olson N., Glass A.G., Rohan T.E. // Cancer Epidemiol. Biomarkers Prevention. 2007. V. 16. № 8. P. 1682.
  12. Yelinova V., Glazachev Y., Khramtsov V., Kudryashova L., Rykova V., Salganik R. // Biochem. Biophys. Res. Commun. 1996. V. 221. № 2. P. 300.
  13. Ohanian M., Telouk P., Kornblau S., Albarede F., Ruvolo Peter, Tidwell R.S., Plesa A., Kangal-Shamanna R., Matera E., Cortes J., Carson A., Dumontet Ch. // Am. J. Hematology. 2020. V. 95. № 4. P. 422. http://doi/org/10.1002/ajh.25731
  14. Kul A. N., Ozturk Kurt B. // Clinical and Experimental Medicine. 2024. V. 24. № 1. P. 1. http://doi/org/10.1007/s10238-024-01349-5
  15. Qayyum M.A., Shah M.H. // Biol. Trace Elem. Res. 2020. V. 194. № 1. P. 34. http://doi/org/10.1007/s12011-019-01746-y
  16. Hasegawa T., InagakI K., Haraguchi H. // Analyt. Sci. 2001. V. 17. P. 979.
  17. Cirovic A., Cirovic A. // Leukemia Res. 2022. V. 112. Р. 106755. http://doi/org/10.1016/j.leukres.2021.106755
  18. Ehudin M.A., Golla U., Trivedi D., Potlakayala S.D., Rudrabhatla S.V., Desai D., Dovat S., Claxton D., Sharma A. // Int. J. Mol. Sci. 2022. V. 23. Р. 7972. http://doi/org/10.3390/ijms23147972
  19. Chrysochou E., Koukoulakis K., Kanellopoulos P.G., Sakellari A., Karavoltsos S., Dassenakis M., Minaidis M., Maropoulos G., Bakeas E. // J. Trace Elements Medicine Biol. 2021. V. 68. Р. 126833. http://doi/org/10.1016/j.jtemb.2021.126833
  20. Schmitt Y., Schneider H. // Nephrology Dialysis Transplantation. 1993. V. 8. № 5. P. 438.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу
2. Fig. 1. Incidence and mortality rates of patients with haemoblastosis from 2018 to 2023.

Жүктеу (179KB)
Метадеректер
3. Fig. 2. Study design. NHL - non-Hodgkin's lymphoma, PCT - polychemotherapy.

Жүктеу (534KB)
Метадеректер
4. Fig. 3. Results of elemental analysis of red bone marrow of leukaemia patients: 1 - before polychemotherapy; 2 - after the first course; 3 - after the second course.

Жүктеу (312KB)
Метадеректер
5. Fig. 4. Results of elemental analysis of red bone marrow of patients with lymphoma: 1 - before polychemotherapy; 2 - after the first course; 3 - after the second course.

Жүктеу (289KB)
Метадеректер

© Russian Academy of Sciences, 2025