Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector10881710.17816/pmj3965-10Research ArticleRole of vitamin D in formation of climacteric syndromeKovalM. V.<pre id="tw-target-text" class="tw-data-text tw-text-large tw-ta" dir="ltr" data-placeholder="Перевод">Candidate of Medical Sciences, Associate Professor, Department of Obstetrics and Gynecology</pre>ariudachina@gmail.comhttps://orcid.org/0000-0003-1321-6583UdachinaA. A.<p>Student</p>ariudachina@gmail.comUral State Medical University0601202339651018062022Copyright © 2023, Eco-Vector2023<p>Menopause is a physiological period during which involutional processes in the reproductive system predominate in a woman's body. Vitamin D deficiency increases the risk of age-related diseases, so it is important to examine and, if necessary, adjust the level of vitamin D. Purpose of the study. To determine the relationship between vitamin D levels and the severity of menopausal syndrome in postmenopausal women. Materials and methods. A cross-sectional study was conducted, which included data on 150 patients who applied for a gynecological appointment with complaints of manifestations of menopausal syndrome (CS). Results. As a result of the study, it was revealed that out of 150 women with manifestations of menopausal syndrome, the average level of 25(OH)D in the blood serum was 25.3(7.5) ng/ml. At the same time, in 49 (33%) of the surveyed, the content of hydroxyvitamin D was normal, a deficiency was observed in 53 (35%), and in 48 (32%), the indicators corresponded to a deficiency. However, the correlation analysis of the relationship between the level of vitamin D and the severity of the climacteric syndrome did not reveal a statistically significant relationship between the studied parameters (p=0.317). Conclusions. The severity of menopausal syndrome does not depend on the level of vitamin D in the blood, which confirms the leading role of hypoestrogenism in the etiopathogenesis of this condition.</p>diseases associated with vitamin D deficiencymenopauseclimactericболезни, ассоциированные с дефицитом витамин Dменопаузаклимактерий[Tatarova N.A., Ajrapetyan M.S. Deficit vitami-na D i zhelezodeficitnaya anemiya u zhenshchin v perekhodnom menopauzal'nom periode. Klinicheskij sluchaj. Ginekologiya 2020; 22 (5): 87–90 (in Russian).][Pestrikova T.Yu., YUrasova E.A., Knya-zeva T.P. Vitamin D kak faktor povysheniya kachestva zhizni u zhenshchin posle 50 let (obzor literatury). ZHurnal ginekologiya 2019; 48–50 (in Russian).][Morozova Yu.E., Tarasova M.A. Fiziologicheskaya rol' vitamina D i znachenie ego deficita v patogeneze klimaktericheskogo sindroma. ZHurnal akusherstva i zhenskih boleznej 2018; 67 (3): 74–82 (in Russian).][Vasil'eva L.V., Tatarinceva Yu.V., Gosteva E.V. Vzaimosvyaz' arterial'noj gipertenzii, metabolicheskogo sindroma s deficitom vitamina D u zhenshchin. Aktual'nye problemy mediciny 2020; 43 (4): 549–559 (in Russian).][Rudenko E.V. Sovremennye tendencii v diagnostike, profilaktike i lechenii deficita vitamina D. Voprosy attestacii i povysheniya kvalifikacii 2020; 8: 31–36 (in Russian).][Ozolina L.A., Savchenko T.N., Safonina M.S. Znachenie vitamina D dlya zdorov'ya zhenshchin perimenopauzal'nogo perioda. Medicinskij sovet 2020; 13: 84–90 (in Russian).][Baber R., Panay N., Fenton S. IMS recommendations on menopausal hormone therapy and preventive strategies for midlife health. Climacteric 2016; 4: 109–150.][Pestrikova T.Yu., YAchinskaya T.V. Klinicheskaya effektivnost' kompleksnogo podhoda k diagnostike i lecheniyu klimaktericheskogo sindroma na fone gipovitaminoza D. Consilium Medicum 2018; 20 (6): 22–25 (in Russian).][Klinicheskie rekomendacii. Osteoporoz. Moscow: Ministerstvo Zdravoohraneniya Rossijskoj Federacii 2016 (in Russian).]