Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector1648210.17816/pmj3645-12Research ArticleRenovasal relationship in patients with uncomplicated hypertensive diseaseChernyavinaA. I.anna_chernyavina@list.ruKoziolovaN. A.koziolova@inbox.ruMironovaS. V.sv.mironova.2017@yandex.ruE.A. Vagner Perm State Medical University171020193645121710201917102019Copyright © 2019, Chernyavina A.I., Koziolova N.A., Mironova S.V.2019<p><strong>Aim.</strong> To assess the influence of arterial stiffness on the renal filtration function in patients with uncomplicated hypertensive disease.</p>
<p><strong>Materials and methods.</strong> The study included 88 patients of able-bodied age, suffering from stage III hypertensive disease. The mean age was 50.38 5.19 years. All the patients underwent sphigmopletismography with assessment of cardio-malleolar-vascular index (CAVI1), evaluation of renal filtration function by creatinine and cystatin C levels as well as by calculated glomerular filtration rate (GFR) by creatinine and cystatin C. All the patients were divided into 3 groups according to CAVI1 level: group 1 patients without arterial lesion and CAVI1 8; group 2 patients with borderline changes in arteries and CAVI1 8.08.9; group 3 patients with arterial lesion and CAVI19.</p>
<p><strong>Results.</strong> No statistically significant differences by clinicoanamnestic characteristics were found out in patients of all groups. In patients of group 1, cystatin level appeared to be statistically significantly lower than in patients of group 2 and 3 (<em>p<sub>mg </sub></em>= 0.013). Patients of all groups statistically significantly differed according to GFR by cystatin C (<em>p<sub>m</sub></em><sub>g </sub>= 0.015). No difference according to creatinine level and GFR by creatinine were registered in the groups.</p>
<p><strong>Conclusions.</strong> As arterial stiffness by CAVI1 level is increased, there occurs statistically significant aggravation of renal filtration function, assessed by cystatin C level and GFR using the formula CKD-EPI by cystatin C. Changes in the renal filtration function indices were observed within the normal values that shows early preclinical changes.</p>Hypertensive diseasearterial stiffnessCAVI1 indexrenal filtration functioncystatin CГипертоническая болезньартериальная жесткостьиндекс CAVI1фильтрационная функция почекцистатин С[Васюк Ю.А., Иванова С.В., Школьник Е.Л., Котовская Ю.В., Милягин В.А., Олейников В.Э., Орлова Я.А., Сумин А.Н., Баранов А.А., Бойцов С.А., Галевич А.С., Кобалава Ж.Д., Кожевникова О.В., Конради А.О., Лопатин Ю.М., Мареев В.Ю., Новикова Д.С., Оганов Р.Г., Рогоза А.Н., Ротарь О.П., Сергацкая Н.В., Скибицкий В.В. Согласованное мнение российских экспертов по оценке артериальной жесткости в клинической практике. Кардиоваскулярная терапия и профилактика 2016; 15 (2): 4–19.][Вельков В.В. Цистатин С и NGAL – маркеры преклинической ренальной дисфункции и субклинического острого повреждения почек. Лабораторная служба 2015; 2: 38–43.][Чазова И.Е., Ратова Л.Г., Бойцов С.А., Небиеридзе Д.В. Диагностика и лечение артериальной гипертензии (Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов). Системные гипертензии 2010; 3: 5–26.][Ecobicia M., Iliescu E.L. Arterial Stiffness and Hypertension – Which Comes First? MAEDICA – a. Journal of Clinical Medicine 2017; 12 (3): 184–190.][Forouzanfar M.H., Liu P., Roth G. A. et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990–2015. JAMA 2017; 317: 165–182.][Garnier A.S., Briet M. Arterial Stiffness and Chronic Kidney Disease. Pulse 2015; 3: 229–241.][Hayashi K., Yamamoto T., Takahara A., Shirai K. Clinical assessment of arterial stiffness with cardio-ankle vascular index: theory and applications. Journal of Hypertension 2015; 33 (9): 1742–1757.][Levey A.S., Stevens L.A., Schmid C.H. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604–612.][Mikael L.R., Gomes de Paiva A.M., Gomes M.M. Vascular Aging and Arterial Stiffness. Arq Bras Cardiol 2017; 109 (3): 253–258.][Nakamura K., Lizuca T., Takanashi M. Association between Cardio-Ankle Vascular Index and serum Cystatin C levels in patients with cardiovascular risk factor. Journal of Atherosclerosis and Thrombosis 2009; 16: 371–379.][Vlachopoulos C., Xaplanteris P., Aboyans V. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 2015; 241 (2): 507–532.][Williams В., Mancia G., Spiering W. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Journal of Hypertension 2018; 36: 1953–2041.]