Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector1648610.17816/pmj36433-38Research ArticleInfluence of polymorphism of the gene GCLC on antioxidant defense status in healthy children of Omsk regionPavlinovaE. B.elena@mail.ruKirshinaI. A.kirshina-irina@mail.ruKurmashevaE. I.katerina.kurmasheva@mail.ruVlasenkoN. Yu.vlaso@mail.ruMingairovaA. G.mingairova1@yandex.ruSavchenkoO. A.olgasav1978@mail.ruIndutnyiA. V.kld-omsk@mail.ruNovikovD. G.novikov.dm.omsk@gmail.comOmsk State Medical University1710201936433381710201917102019Copyright © 2019, Pavlinova E.B., Kirshina I.A., Kurmasheva E.I., Vlasenko N.Y., Mingairova A.G., Savchenko O.A., Indutnyi A.V., Novikov D.G.2019<p><strong>Aim.</strong> To study the status of antioxidant defense in healthy children, living in Omsk Region, depending on polymorphism of the gene GCLC.</p>
<p><strong>Materials and methods.</strong> There were examined 50 healthy children aged 3 to 17 years, including 54 % of boys. Polymorphism of the gene GCLC 129С/C, 129C/Т, 129T/T and reduced (GSH) and oxidized (GSSG) glutathione concentrations were determined. Statistical analysis was implemented using the programs Statistica 6.0 and DoctorStat1.9.</p>
<p><strong>Results.</strong> Polymorphism of the gene GCLC was represented by the genotypes 129C/C (43 children, 86 %) and 129C/T (7 children, 14 %); GSH concentration was within 6.0 [4.4; 7.0] mcmol/l, GSSG concentration 3.0 [2.3; 3.5] mcmol/l, GSH:GSSG ratio was 2:1. Weak direct correlation between the child age and GSH (<em>r</em> = 0.31; <em>р</em> = 0.028) and GSSG (<em>r</em> = 0.31; <em>р</em> = 0.031) content was established; no gender differences were revealed. Among the subjects with the genotype 129C/T, the blood plasma GSH (<em>р</em> = 0.017) and GSSG (<em>р</em> = 0.016) concentrations decreased by 30 %.</p>
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