Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector308210.17816/pmj33244-49Research ArticleGENDER PECULIARITIES OF LEPTIN, SOLUBLE LEPTIN RECEPTORS AND RESISTIN LEVELS IN PATIENTS SUFFERING FROM ARTERIAL HYPERTENSION ASSOCIATED WITH OBESITYShulkinaS Gshulkina-s@mail.ru15042016332444912072016Copyright © 2016, Shulkina S.G.2016Aim. At present, the problem of obesity as a risk factor for cardiovascular diseases remains actual. The aim of the work was to assess the gender peculiarities of the levels of adipokin and soluble leptin receptors in patients suffering from arterial hypertension (AH) associated with obesity. Materials and methods. The study enclosed 70 patients with AH. The parameters: mean body mass index (BMI) - 38,0 ± 9 kg/m2, mean age - 48,2 ± 2,4 years. There were 40 patients with obesity without AH and metabolic disorders and 30 practically healthy persons comparable by sex and age. Results. Leptin and resistin levels were reliably higher, but soluble leptin receptor concentration was lower in the group of AH patients with obesity. In the group of women, higher concentrations of leptin and resistin, and lower concentrations of soluble leptin receptors were observed than in the group of men. Correlation analysis indicated direct correlation of leptin and resistin with BMI, HOMA and TH indices, DAP level and reverse correlation of soluble leptin receptors with HOMA index. Conclusions. Thus, hormonal status of adipose tissue in women suffering from AH associated with obesity is characterized by higher leptin and resistin levels than in men. The cause of leptin resistance can be a low level of soluble leptin receptors.Arterial hypertensionobesityleptinresistinsoluble leptin receptorsАртериальная гипертензияожирениелептинрезистинрастворимые рецепторы лептина[Беспалова И.Д., Рязацева И.В., Каменских В.В. Гендерные особенности взаимосвязи гормональной активности жировой ткани и провоспалительного статуса при гипертонической болезни и метаболическом синдроме. Бюллетень Сибирской медицины 2014; 13 (5): 12-19.][Бунова С.С. Динамика изменений нейрогуморального профиля и формирование метаболических нарушений у больных артериальной гипертензией в зависимости от массы тела. Вестник Санкт-Петербургс-кого университета 2009; 1: 11-18.][Вербовой А.Ф., Митрошина Е.В. Адипокины и сердечно-сосудистая система. Эндокринология. Новости, мнения, обучение 2014; 2: 5-7.][Дедов И.И., Мельниченко Г.А., Бутрова С.А. Жировая ткань как эндокринный орган. Ожирение и метаболизм 2006; 1: 6-13.][Коваренко М.А., Руяткина Л.А., Петрищева М.С. Лептин: физиологические и патологические аспекты действия. Вестник НГУ. Серия: Биология, клиническая медицина 2003; 1 (1): 59-74.][Catli G., Anik A., Tuhan H.Ü., Kume T., Bober E., Abaci A. The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children. Peptides 2014; 56: 72-76.][Harris R.B. Direct and indirect effects of leptin on adipocyte metabolism. Biochim Biophys Acta 2014; 1842 (3): 414-423.][Koh K.K., Park S.M., Michael J. Leptin and cardiovascular disease. Circulation 2008; 117 (25): 3238-3249.][Marouga A., Dalamaga M., Kastania A.N., Kroupis C., Lagiou M. Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease. Biomarkers 2015; 15: 1-7.][Sun Q., van Dam R.M., Meigs J.B., Franco O.H., Mantzoros C.S., Hul F.B. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. Women. Diabetes 2010; 59: 611-618.][Wolfgang L., Sullivan L.M., Harris T.B., Roubenoff R., Benjamin M.J., Levy D., Fox C.S., Wang T.J., Wilson P.W., Kannel W.B., Vasan R.S. Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals. Diabetes care 2009; 32: 612-616.]