Aim. To analyze the drug therapy in patients after acute coronary syndrome. Materials and methods. Drug treatment of 257 patients who had suffered from acute coronary syndrome was analyzed after their discharge from the unit of urgent cardiology of Smolensk Clinical Emergency Hospital. Results. Shortcomings of drug therapy used for treatment of patients after acute coronary syndrome were revealed. In six months, 61,9 % of patients received statins, 76,19 % - clopidogrel, 73,81 % - beta-adrenergic blocking agents; by the end of the year - 53,52 %, 59,15 %, 70,42 % of patients, respectively. From one-third (in 6 months of follow-up observation) to half (in a year of follow-up observation) of patients were not observed at the polyclinic and in most cases did not receive an adequate drug therapy. Conclusions. Patients who suffered from acute coronary syndrome are not always followed up at the polyclinic after their discharge form the hospital and demonstrate a low loyalty to statin, clopidogrel and beta-blocker therapy. In some cases, ambulatory physicians abolish these drugs without any grounds for that.