Perm Medical JournalPerm Medical JournalПермский медицинский журнал (сетевое издание "Perm medical journal")0136-14492687-1408Eco-Vector32121010.17816/pmj40462-72Review of literatureОбзор литературыReview ArticleRole of oxidative stress in female reproductive system: literature reviewРоль окислительного стресса в женской репродуктивной системе: обзор литературыhttps://orcid.org/0000-0003-4685-67718696-2674BerezinaDinara A.БерезинаДинара Арифовна
Russian Federation

Postgraduate Student, Department of Obstetrics and Gynecology

аспирант кафедры акушерства и гинекологии

dinara-berezina@mail.ruhttps://orcid.org/0000-0003-2797-19267232-3743KudryavtsevaElena V.КудрявцеваЕлена Владимировна
Russian Federation

MD, PhD, Associate Professor, Head of the Central Scientific Research Laboratory

доктор медицинских наук, доцент, заведующий Центральной научно-исследовательской лабораторией

elenavladpopova@yandex.ruhttps://orcid.org/0000-0003-0806-11776123-5380GavrilovIlia V.ГавриловИлья Валерьевич
Russian Federation

Candidate of Biological Sciences, Associate Professor of the Department of Biological Chemistry, Senior Researcher of CSRL

кандидат биологических наук, доцент кафедры биохимии, старший научный сотрудник Центральной научно-исследовательской лаборатории

iliagavrilov18@yandex.ruUral State Medical UniversityУральский государственный медицинский университет24072023404627209032023Copyright ©; 2023, Eco-VectorCopyright ©; 2023, Эко-Вектор2023Eco-VectorЭко-Векторhttps://permmedjournal.ru/PMJ/article/view/321210

In this review, the literature data regarding the influence of oxidative stress (OS) on the female reproductive system and fertility are analyzed. Oxidative stress occurs as a result of balance disturbance in the system of the formation of free radicals and mechanisms of antioxidant defense. During the last decade, there have been conducted many studies, demonstrating interaction between the oxidative stress and the development of various pathological processes. The influence of the oxidative stresses on the state of female reproductive system and fertility is of special interest. When analyzing the available for today data regarding OS and its effect on the body, it is becomes evident that this process is very important in physiology and reproductive pathology, development of gynecological and obstetric pathologies and fertility. The significance of OS in the pathogenesis of reproductive disturbances should be taken into account when developing new therapeutic methods. This issue needs further discussion and studying.

Проанализированы литературные данные, касающиеся влияния окислительного стресса на женскую репродуктивную систему и фертильность. Окислительный стресс возникает в результате нарушения баланса в системе образования свободных радикалов и механизмов антиоксидантной защиты. В последние десятилетия проведено много исследований, демонстрирующих связь между окислительным стрессом и развитием тех или иных патологических процессов. Особый научный и практический интерес представляет влияние окислительного стресса на состояние женской репродуктивной системы и фертильности. В результате анализа имеющихся на сегодняшний день данных об окислительном стрессе и его влиянии на организм становится очевидным особое значение этого процесса в физиологии и патологии репродуктивной системы, развитии гинекологических и акушерских патологий, и, наконец, фертильности. Значение окислительного стресса в патогенезе репродуктивных нарушений нужно учитывать при разработке новых методов терапии. Можно с уверенностью говорить о том, что вопрос нуждается в дальнейшем обсуждении и изучении.

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