Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector326510.17816/pmj33148-52Research ArticleLESION OF VISUAL ORGAN IN HIV-INFECTED PATIENTS OF PERM KRAIGavrilovaT Vgavrilova.tv@mail.ruShmagelN G-ChereshnevaM V-15022016331485212072016Copyright © 2016, Gavrilova T.V., Shmagel N.G., Chereshneva M.V.2016Aim. The aim of the study was to analyze the ophthalmic pathology in HIV-infected patients of Perm Krai. Materials and methods. Medical documentation of 224 patients, registered at Perm Regional Center for Prevention and Control of AIDS as well as patients treated at ophthalmological departments of Perm, was analyzed. Results. Changes in the visual organ were detected in 92 persons on 151 eyes (41 % of all the examined patients). There were 61,96 % of men and 38,04 % of women; the mean age was 33,37 ± 8,08 years. The most frequently occurring pathologies were retinal mioangiopathy (58,29 %), seldom - uveitis (9,27 %), cataract (7,28 %), retinitis, blepharitis - 3,97 % each, conjunctivitis, optic neuritis - 2,65 % each, uveoneuritis - 1,32 %, orbit phlegmon, hyposphagma - 0,67 % each; visual injuries: apple contusion - 3,97 %, eyelid wounds - 3,31 %, penetrating eye wound - 1,32 %. Conclusions. Visual lesion more often occurred in subjects with decreased level of CD4-cells; most of them did not receive antiretroviral therapy, mainly those with severe ophthalmic pathology. Ophthalmologists should be especially careful to HIV-infected patients.HIV-infectionophthalmic pathologyantiretroviral therapyimmunodeficiencyВИЧ-инфекцияпатология глазантиретровирусная терапияиммунодефицит[ВИЧ-инфекция и СПИД: клинические рекомендации. Под ред. А.В. Покровского. М.: ГЭОТАР-Медиа 2006; 128.][Марченко Н.Р., Шахгильдян В.И., Шипулина О.Ю., Кравченко А.В. Вирусные поражения органа зрения у больных ВИЧ-инфекцией. Эпидемиология и инфекционные болезни 1998; 5: 36-38.][Махачева З.А., Аванесова Л.А. СПИД и глаз. Махачкала 2001; 72.][Покровский В.В., Юрин О.Г., Кравченко А.В. Протоколы диспансерного наблюдения и лечения больных ВИЧ-инфекцией. Эпидемиология и инфекционные болезни. Актуальные вопросы 2014; 6: 43.][Хижняк Т.В., Астахов Ю.С., Рахманова А.Г. Структура заболеваний глаза в зависимости от стадии ВИЧ-инфекции. Офтальмологические ведомости 2009; 2: 15-19.][De Clercq E. Antiretroviral drugs. Curr. Opin. Pharmacol. 2010; 10 (5): 507-515.][Doherty K., Essajee S., Penazzato M. Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations. BMC Health Serv. Res. 2014; 14: 201.][Jordan M.R., Bennett D.E., Wainberg M.A. Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004-2011. Clin. Infect. Dis. 2012; 54: 245-249.][Larson H.J., Bertozzi S., Piot P. Redesigning the AIDS response for long-term impact. Bulletin of the World Health Organization 2011; 89 (11): 846-852.][Mines J.A., Kaplan H.J. Acquired immunodeficiency syndrome (AIDS): the disease and its ocular manifestations. Int Ophthalmol. Clin. 1986; 26 (2): 73-115.][Pau A.K., George J.M. Antiretroviral therapy: current drugs. Infect Dis. Clin. North. Am. 2014; 28 (3): 371-402.][Stover J., Hallett T.B., Wu Z. How can we get close to zero? The potential contribution of biomedical prevention and the investment framework towards an effective response to HIV. PLoS One 2014; 9 (11).]