Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector46572010.17816/pmj4025-10Research ArticleCorrelation between type 2 diabetes mellitus and pancreatic steatosisTanaevaT. A.<p>postgraduate student, Department of General Medical Practice and Internal Diseases with Course of Emergency of the Advanced Training Faculty and Occupational Training</p>Shklyaeva2011@ya.ruIvanovL. A.<p>MD, PhD, Professor, Department of General Medical Practice and Internal Diseases with Course of Emergency of the Advanced Training Faculty and Occupational Training</p>Shklyaeva2011@ya.ruIzhevsk State Medical Academy020620234025102905202329052023Copyright © 2023, Eco-Vector2023<p><strong>Objective</strong><strong>. </strong>To study the features of endocrine function in non-alcoholic fatty disease of the pancreas in patients with chronic pancreatitis in remission.</p>
<p><strong>Materials</strong><strong> and methods. </strong>There were examined 62 patients with chronic pancreatitis without exacerbation, who were admitted to the day hospital department of the City Clinical Hospital № 9 (Izhevsk). The data of laboratory and instrumental research methods, the features of the pancreatic endocrine function in patients with chronic pancreatitis, accompanied by fatty degeneration of the organ were analyzed.</p>
<p><strong>Results</strong><strong>. </strong>Pancreatic steatosis was detected in 80.8 % of cases in patients with chronic pancreatitis in remission with metabolically complicated obesity. Violation of endocrine function was diagnosed in 19.3 % of cases. In the presence of insulin resistance, 6 (16.7 %) of the examined patients were diagnosed type 2 diabetes for the first time. At high insulin levels, 4 (6.5 %) patients had no changes in the indicators of fasting sugar.</p>
<p><strong>Conclusions</strong><strong>. </strong>All patients with increased insulin resistance and metabolically complicated obesity require a comprehensive clinical and laboratory-instrumental study for the early detection of non-alcoholic fatty pancreatic disease. When establishing the signs of fatty degeneration of the pancreas, dispensary observation as well as prophylactic and therapeutic measures are necessary to prevent the development of type 2 diabetes mellitus.</p>pancreatic steatosischronic pancreatitisobesityinsulin resistanceстеатоз поджелудочной железыхронический панкреатитожирениеинсулинорезистентность[Zvenigorodskaya L.A., Khachaturian N.E. Functional and clinical and morphological changes in the pancreas in metabolic syndrome. Consilium Medicum. 2016; 18 (8): 51–58 (in Russian).][Afanasiev Yu.I., Kuznetsov S.L., Yuri¬na N.A. Hystology, cytology and embryology. Moscow.: Medicine, 2004; 768 (in Russian).][Maksimov V.A., Dalidovich K.K., Fedoruk A.M., Morozkina T.S., Kulikov A.G. Dideases of civilization: systemic metabolic lesions. M.: Adamant Publishing House 2020; 672 (in Russian).][Gubergrits N.B., Khristich, Bonda¬ren¬ko O.A. Non-alcoholic fatty pancreatic disease. Doneck: OO «Lebed» 2013; 236 (in Russian).][Sas E.I., Kravchuk Yu.A., Efimov O.I. Obesity: a view of a gastroenterologist and options for drug treatment. Almanac of Clinical Medicine 2015; 1: 24–29.][Smith M.M., MGeen E.J. The clinical significance of pancreatic steatosis. Nat. Rev. Gastroenterol. Hepatol. 2011; 18: 169–177.]