<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Perm Medical Journal</journal-id><journal-title-group><journal-title xml:lang="en">Perm Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Пермский медицинский журнал (сетевое издание "Perm medical journal")</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0136-1449</issn><issn publication-format="electronic">2687-1408</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">562942</article-id><article-id pub-id-type="doi">10.17816/pmj404127-134</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Случай из практики</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Allergic bronchopulmonary aspergillosis (known unknown disease, analysis of clinical observation)</article-title><trans-title-group xml:lang="ru"><trans-title>Аллергический бронхолегочный аспергиллез (известная неизвестная болезнь, анализ клинического наблюдения)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barlamov</surname><given-names>O. P.</given-names></name><name xml:lang="ru"><surname>Барламов</surname><given-names>О. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Medical Sciences, Chief Physician</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, главный врач</p></bio><email>barlamov@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8704-692X</contrib-id><name-alternatives><name xml:lang="en"><surname>Barlamov</surname><given-names>P. N.</given-names></name><name xml:lang="ru"><surname>Барламов</surname><given-names>П. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>barlamov@inbox.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Vesna Medical Group</institution></aff><aff><institution xml:lang="ru">Весна Медикал Груп</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">E.A. Vagner Perm State Medical University</institution></aff><aff><institution xml:lang="ru">Пермский государственный медицинский университет имени академика Е.А. Вагнера</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-24" publication-format="electronic"><day>24</day><month>07</month><year>2023</year></pub-date><volume>40</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>127</fpage><lpage>134</lpage><history><date date-type="received" iso-8601-date="2023-07-24"><day>24</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-24"><day>24</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://permmedjournal.ru/PMJ/article/view/562942">https://permmedjournal.ru/PMJ/article/view/562942</self-uri><abstract xml:lang="en"><p/><p>To show an algorithm for diagnosing this disease and demonstrate the effectiveness of etiological treatment using the case history of a patient with allergic bronchopulmonary aspergillosis (ABPA) against the background of bronchial asthma (BA).</p> <p>Complaints, anamnesis, physical status, laboratory and instrumental studies of a patient with ABPA are published. Modern literature data on the diagnosis and treatment of ABPA have been analyzed.</p> <p>The complaints, anamnesis, physical status as well as laboratory and instrumental studies used for a patient with ABPA were analyzed in comparison with world literature data.</p> <list list-type="order"> <list-item><p>Primary care physicians are informed insufficiently about the clinical picture of ABPA. 2. Antimycotic therapy with variconazole applied for patients with ABPA against the background of BA leads not only to positive morphological changes in the lungs but also to the relief of BA course.</p></list-item> </list></abstract><trans-abstract xml:lang="ru"><p>На примере истории болезни пациентки с аллергическим бронхолегочным аспергиллезом (АБЛА) на фоне бронхиальной астмы (БА) показать алгоритм диагностики этого заболевания и продемонстрировать эффективность этиологического лечения. Опубликованы жалобы, анамнез, физикальный статус, лабораторные и инструментальные исследования пациентки с АБЛА. Проработаны современные литературные данные по диагностике и лечению АБЛА. Проведен анализ жалоб, анамнеза, физикального статуса, лабораторных и инструментальных исследований пациентки с АБЛА в сопоставлении с мировыми литературными данными.</p> <p>Сделаны определенные выводы: 1. Первичное звено врачей недостаточно информировано о клинической картине АБЛА. 2. Противомикотическая терапия вориконазолом больных АБЛА на фоне БА приводит не только к положительным морфологическим изменениям легких, но и к облегчению течения БА.</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergic bronchopulmonary aspergillosis</kwd><kwd>bronchial asthma</kwd><kwd>variconazole</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллергический бронхолегочный аспергиллез</kwd><kwd>бронхиальная астма</kwd><kwd>вориконазол</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Li E., Knight J.M., Airway Wu. Y. mycosis in allergic airway disease. Adv Immunol. 2019; 142: 85–140. DOI: 10.1016/bs.ai.2019.05.002.</mixed-citation></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Minaeva N.V., Islamova R.I., Plakhina K.V. Fungal sensitization in patients with pollinosis: a review. Pediatrics. The journal named after G.N. Speransky 2022; 101 (2): 73–77 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Минаева Н.В., Исламова Р.И., Плахина К.В. Грибковая сенсибилизация у пациентов с поллинозом: обзор. Педиатрия. Журнал имени Г.Н. Сперанского 2022; 101 (2): 73–77.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Kozlova Ya. I., Kuznetsov V.D., Klimko N.N. Fungi of the genus Aspergillus and chronic lung diseases. Doctor. 2020.11: 14–20. Agarwal R., Sehgal I.S., Dhooria S., Aggarwal A.N. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Review of Respiratory Medicine 2016; 10 (12): 1317–34 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Козлова Я.И., Кузнецов В.Д., Климко Н.Н. Грибы рода Aspergillus и хронические заболевания легких. Врач 2020; 11: 14–20.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Agarwal R., Sehgal I.S., Dhooria S., Ag-garwal A.N. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Review of Respiratory Medicine 2016; 10 (12): 1317–34.</mixed-citation><mixed-citation xml:lang="ru">Agarwal R., Sehgal I.S., Dhooria S., Aggarwal A.N. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Review of Respiratory Medicine 2016; 10 (12): 1317–34.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><mixed-citation>Kanj A., Abdallah N., Soubani A.O. The spectrum of pulmonary aspergillosis. Respiratory Medicine 2018; 141: 121–31.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hinson K.F., Moon A.J., Plummer N.S. Bronchopulmonary aspergillosis; a review and a report of eight new cases. Thorax 1952; 7 (4): 317–33.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Wark P., Hensley M., Saltos N. Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial. J Allergy Clin Immunol. 2003; 111 (5): 952–7. DOI: 10.1067/mai.2003.1388.</mixed-citation></ref></ref-list></back></article>
