Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector569310.17816/pmj33478-81Research ArticlePATHOMORPHOLOGICAL CHANGES IN RAT PANCREATIC TISSUES CAUSED BY LONG ADMINISTRATION OF NIMESULIDELazarenkoL Vmail@pifsin.ruKosarevaP V-SamodelkinE I-KhorinkoV P-15082016334788118112016Copyright © 2016, Lazarenko L.V., Kosareva P.V., Samodelkin E.I., Khorinko V.P.2016Aim. The aim of the study was to assess the character of pancreatic tissue lesion in experimental animals when modeling NSAIDs-pancreatopathy using the generally accepted methods. Materials and methods. Modeling of NSAIDs-induced lesion of pancreatic gland in nonlinear white rats was performed by means of per oral introduction of nimesulide (Nise®) during 21 days in the following doses: 0,5 mg/kg (therapeutic dose), 2,5 and 5,0 mg/g. The results were compared with the control group. By the end of experiment, histological material was taken (tissue samples) with observation of ephthanasia rules. Histological methods were used by standard protocols. Results. When using nimesulide (per orally) during 21 days, histopathological changes typical for toxic pancreatitis (vacuolar degeneration, necroses, acinus structure impairment) with marked dose-dependent effect were detected in animal pancreatic parenchyma. In animals with NSAIDs-induced lesion of the pancreas, mast cell were revealed, the number of which visually increased with growth of the dose of this drug.Nonsteroid anti-inflammatory drugs (NSAIDs)NSAIDs-pancreatopathynimesulidehistopathological changesНестероидные противовоспалительные препаратыНПВП-панкреопатиянимесулидгистопатологические изменения[Дроздов В.Н. Гастропатии, вызванные нестероидными противовоспалительными препаратами: патогенез, профилактика и лечение. Consilium medicum 2005; 7: 1.][Каратеев А.Е. Лечение и медикаментозная профилактика НПВП-гастропатии: основные положения. Фарматека 2011; 6: 121-129.][Федотова А.П., Чибыева Л.П., Васильев Н.Н. Гастродуоденальные эрозивно-язвенные повреждения, индуцированные приемом нестероидных противовоспалительных препаратов, в условиях республики Саха. Якутский медицинский журнал 2010; 3(31); 24-27.][Antonopoulos S., Mikros S., Kokkoris S., Protopsaltis J., Filioti K., Karamanolis D., Giannoulis G. A case of acute pancreatitis possibly associated with combined salicylate and simvastatin treatment. JOP. J. Pancreas (Online) 2005; 6: 264-268.][Eland I.A., van Puijenbroek E.P., Sturkenboom M.J., Wilson J.H., Stricker B.H. Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in the Netherlands. Am. J. Gastroenterol. 1999; 94: 2417-22.][Memis D., Akalin E., Yücel T. Indomethacin-Induced Pancreatitis: A Case Report. JOP. J. Pancreas (Online) 2005; 6(4): 344-347.][Nigwekar SU, Casey KJ. Metronidazole-induced pancreatitis. A case report and review of literature. JOP. J. Pancreas (Online) 2004; 5: 516-519.][Pezzilli R., Morselli-Labate A.M., Corinaldesi R. NSAIDs and Acute Pancreatitis: A Systematic Review. Pharmaceuticals 2010; 3: 558-571.][Ruppert G.B., Barth W.F. Ibuprofen hypersensitivity in systemic lupus erythematosus. South. Med. J. 1981; 74: 241-243.][Singh S., Nautiyal A., Dolan J.G. Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect? JOP. J Pancreas (Online) 2004; 5: 502-504.][Trivedi C.D., Pitchumoni C.S. Drug-Induced Pancreatitis. J. Clin. Gastroenterol. 2005; 39:709-716.][UK Working Party on acute pancreatitis. UK guidelines for the management of acute pancreatitis. Gut 2005; 54:iii1-9.]