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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Perm Medical Journal</journal-id><journal-title-group><journal-title xml:lang="en">Perm Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Пермский медицинский журнал (сетевое издание "Perm medical journal")</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0136-1449</issn><issn publication-format="electronic">2687-1408</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">624040</article-id><article-id pub-id-type="doi">10.17816/pmj41150-58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original studies</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Predictors of changes in the course of breast cancer: the results of longitudinal study</article-title><trans-title-group xml:lang="ru"><trans-title>Предикторы изменения течения рака молочной железы: результаты лонгитюдного исследования</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7912-9039</contrib-id><name-alternatives><name xml:lang="en"><surname>Vazhenin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Важенин</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of the Department of Oncology, Radiodiagnosis and Radiotherapy</p></bio><bio xml:lang="ru"><p>заведующий кафедрой онкологии, лучевой диагностики и лучевой терапии, доктор медицинских наук, академик РАН, профессор</p></bio><email>vav222@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9000-7238</contrib-id><name-alternatives><name xml:lang="en"><surname>Pakhomova</surname><given-names>Ya. N.</given-names></name><name xml:lang="ru"><surname>Пахомова</surname><given-names>Я. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Psychological Sciences, Senior Researcher of the Laboratory of Psychophysiology, Faculty of Psychology</p></bio><bio xml:lang="ru"><p>старший научный сотрудник лаборатории психофизиологии факультета психологии, кандидат психологических наук</p></bio><email>sizova159@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8600-3533</contrib-id><name-alternatives><name xml:lang="en"><surname>Ponomareva</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Пономарева</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Psychological Sciences, Associate Professor, Senior Researcher of the Laboratory of Psychophysiology, Faculty of Psychology</p></bio><bio xml:lang="ru"><p>старший научный сотрудник лаборатории психофизиологии факультета психологии, кандидат психологических наук, доцент</p></bio><email>ivp-csu@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7065-0234</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsiring</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Циринг</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Psychology, Professor, Chief Researcher of the Laboratory of Psychophysiology, Faculty of Psychology</p></bio><bio xml:lang="ru"><p>главный научный сотрудник лаборатории психофизиологии факультета психологии, доктор психологических наук, профессор</p></bio><email>l-di@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8309-8047</contrib-id><name-alternatives><name xml:lang="en"><surname>Ryazhkin</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Ряжкин</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Psychological Sciences, Senior Teacher</p></bio><bio xml:lang="ru"><p>старший преподаватель, кандидат психологических наук</p></bio><email>aoryazhkin@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">South Ural State Medical University</institution></aff><aff><institution xml:lang="ru">Южно-Уральский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Tomsk State University</institution></aff><aff><institution xml:lang="ru">Томский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Chelyabinsk State University</institution></aff><aff><institution xml:lang="ru">Челябинский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2024</year></pub-date><volume>41</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>50</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2023-11-29"><day>29</day><month>11</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://permmedjournal.ru/PMJ/article/view/624040">https://permmedjournal.ru/PMJ/article/view/624040</self-uri><abstract xml:lang="en"><p><bold>Objective</bold><bold>.</bold> To investigate the predictors of changes in the course of breast cancer in a longitudinal study.</p> <p><bold>Materials</bold><bold> and methods. </bold>Women with the diagnosis of breast cancer underwent psychological diagnostics at the stage of diagnosis (<italic>n</italic>=201 at the first section of the longitudinal study, <italic>n</italic>=149 at the second section, <italic>n</italic>=94 at the third section, <italic>n</italic>=81 at the fourth section five years after the diagnosis). Methods of research: scale of basic beliefs, life orientations test, questionnaire “Ways of coping behavior”, test of vitality, questionnaire of subjective control, personal helplessness questionnaire, quality of life questionnaire.</p> <p><bold>Results</bold><bold>. </bold>Predictors of changes in the course of cancer are the basic belief “I-Image”, the level of vitality, the locus of control in relation to health, the course and stage of the disease.</p> <p><bold>Conclusions</bold><bold>. </bold>While conducting the study, it was found out that the course of the disease is associated with medical and psychological indicators. The data obtained as a result of the study are necessary for solving practical problems of increasing life expectancy and providing psychological care to women with breast cancer who are a socially vulnerable category of the population of the Russian Federation.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель.</bold> Изучить предикторы изменения течения рака молочной железы в ходе лонгитюдного исследования.</p> <p><bold>Материалы и методы. </bold>Психологическую диагностику прошли женщины с диагнозом рака молочной железы на этапе постановки диагноза (<italic>n</italic> = 201 при первом срезе лонгитюдного исследования, <italic>n</italic> = 149 при втором срезе, <italic>n</italic> = 94 на третьем срезе, <italic>n</italic> = 81 на четвертом срезе по прошествии пяти лет с момента постановки диагноза). Методики исследования: шкала базисных убеждений, тест жизненной ориентаций, опросник «Способы совладающего поведения», тест жизнестойкости, тест-опросник субъективного контроля, опросник личностной беспомощности, опросник качества жизни.</p> <p><bold>Результаты. </bold>Предикторами изменения течения онкологического заболевания выступают базисное убеждение «Образ “Я”», уровень жизнестойкости, показатель локуса контроля в отношении здоровья, течение и стадия заболевания.</p> <p><bold>Выводы. </bold>В результате проведенного исследования обнаружено, что динамика течения болезни связана с медицинскими и психологическими показателями. Полученные данные являются необходимыми для решения практических задач увеличения продолжительности жизни и оказания психологической помощи социально уязвимой категории населения РФ – женщинам с раком молочной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>medical psychology</kwd><kwd>breast cancer</kwd><kwd>oncopsychology</kwd><kwd>course of the disease</kwd><kwd>predictors of the course of the disease</kwd><kwd>longitudinal study</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>медицинская психология</kwd><kwd>рак молочной железы</kwd><kwd>онкопсихология</kwd><kwd>течение болезни</kwd><kwd>предикторы течения болезни</kwd><kwd>лонгитюдное исследование</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Российский научный фонд</institution></institution-wrap><institution-wrap><institution xml:lang="en">Russian Science Foundation</institution></institution-wrap></funding-source><award-id>19-18-00426</award-id></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kim S.Y., Jhon M., Kissane D.W. 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