Perm Medical JournalPerm Medical JournalПермский медицинский журнал (сетевое издание "Perm medical journal")0136-14492687-1408Eco-Vector62539810.17816/pmj41360-76Literature reviewОбзор литературыReview ArticleThe effectiveness of photodynamic therapy in pediatric practiceЭффективность фотодинамической терапии в педиатрической практикеhttps://orcid.org/0009-0005-6516-3446OsipovS. A.ОсиповС. А.
Russian Federation

Postgraduate

аспирант

olofb@list.ruhttps://orcid.org/0009-0003-9088-8321AlievM. A.АлиевМ. А.
Russian Federation

Student

студент

olofb@list.ruhttps://orcid.org/0009-0009-1979-2208DaribaevaN. A.ДарибаеваН. А.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0009-0001-4491-9495MurtazinA. A.МуртазинА. А.
Russian Federation

Assistant

ассистент

olofb@list.ruhttps://orcid.org/0009-0000-7001-553XAgaevaF. L.АгаеваФ. Л.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0009-0001-0631-9851KhairullinaA. A.ХайруллинаА. А.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0009-0008-0900-8697ShalganovaK. S.ШалгановаК. С.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0009-0005-4075-5664FilippovaA. A.ФилипповаА. А.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0009-0004-5867-649XIksanovaV. V.ИксановаВ. В.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0000-0002-9330-2117ZhidenkoM. A.ЖиденкоМ. А.
Russian Federation

Student

студентка

olofb@list.ruhttps://orcid.org/0000-0003-1100-1394SalatovYa. S.СалатовЯ. С.
Russian Federation

Student

студент

olofb@list.ruI.P. Pavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаBashkir State Medical UniversityБашкирский государственный медицинский университетSamara State Medical UniversityСамарский государственный медицинский университетRussian University of MedicineРоссийский университет медициныFar Eastern Federal UniversityДальневосточный федеральный университет19072024413607628122023Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://permmedjournal.ru/PMJ/article/view/625398

Photodynamic therapy (PDT) is a relatively young but rapidly developing method of treatment. Currently, PDT is widely used in dentistry, dermatology, oncology and other fields of medicine. Cases of successful treatment of tumors of the head and neck, brain, lungs, pancreas, colon, breast, prostate, bladder, cervix and skin using PDT are described in literature. In addition, the effectiveness of PDT in the treatment of bacterial and fungal infections has been repeatedly proved. To date, there are a large number of studies on the use of PDT in various diseases in adults, but few data on this subject in children. The authors have been searching for publications in the electronic databases PubMed, Google Scholar and eLibrary by the following keywords: "PDT", "photodynamic therapy", "pediatrics", "children", "dermatology", "dentistry", "pulmonology", "ophthalmology", "oncology". The search was conducted from the moment of the foundation of the corresponding database to August 2023. PDT is an innovative method of treating neoplasms and bacterial infections. On the basis of the data obtained while conducting the study, it can be confirmed that applying PDT allows to reduce the number of surgical interventions and achieve the best treatment results. All the studies and clinical cases with the use of PDT in the treatment of various diseases in children, which are presented in this review, demonstrated that the treatment results were better than those with standard therapy. However, certain limitations must be taken into account, these include difficulties in selecting a photosensitizer and its route of administration. At present PDT is being actively studied in the pediatric population, but there are still many gaps that require additional large-scale studies.

Осуществлен анализ литературных данных, посвященных использованию фотодинамической терапии (ФДТ) при различных заболеваниях в педиатрической популяции. ФДТ – относительно молодой, но быстро развивающийся метод лечения. В настоящее время ФДТ активно применяется в стоматологии, дерматологии, онкологии и других областях медицины. В литературе описаны случаи успешного лечения опухолей головы и шеи, головного мозга, легких, поджелудочной железы, толстой кишки, молочной железы, простаты, мочевого пузыря, шейки матки и кожи с использованием ФДТ. Кроме того, неоднократно доказывалась эффективность использования ФДТ в терапии бактериальных и грибковых инфекций. На сегодняшний день имеется большое количество исследований, посвященных применению ФДТ при различных заболеваниях у взрослых, однако данные по детям ограничены. Авторами был проведен поиск публикаций в электронных базах данных PubMed, Google Scholar и ELibrary. Поиск проводился по следующим ключевым словам: PDT, photodynamic therapy, pediatric, children, dermatology, dentistry, pulmonology, ophthalmology, oncology, «ФДТ», «фотодинамическая терапия», «педиатрия», «дети», «дерматология», «стоматология», «пульмонология», «офтальмология», «онкология». Поиск проводился во временном интервале с момента основания соответствующей базы данных по август 2023 г.

ФДТ является инновационным методом лечения новообразований и бактериальных инфекций. Основываясь на имеющихся данных, можно утверждать, что ФДТ позволяет сократить количество хирургических вмешательств и добиться наилучших результатов лечения. Все исследования и клинические случаи использования ФДТ в терапии различных заболеваний у детей, представленные в настоящем обзоре, продемонстрировали, что результаты лечения были лучше, чем при проведении стандартной терапии. Однако необходимо учитывать наличие определенных ограничений, включая трудности с подбором фотосенсибилизатора и его пути введения. На сегодняшний день ФДТ активно изучается в педиатрической популяции, однако остается много пробелов, которые требуют проведения дополнительных масштабных исследований.

Photodynamic therapyPDTdermatologypediatricschildrenoncologyophthalmologydentistryФотодинамическая терапияФДТдерматологияпедиатриядетионкологияофтальмологиястоматологияDaniell M.D., Hill J.S. A history of photodynamic therapy. Aust N Z J Surg. 1991; 61 (5): 340–348. DOI: 10.1111/j.1445-2197.1991. tb00230.x.Acedo P., Stockert J.C., Cañete M., Villanueva A. Two combined photosensitizers: a goal for more effective photodynamic therapy of cancer. Cell Death Dis. 2014; 5 (3): 1122. DOI: 10.1038/cddis.2014.77.Dos Santos A.F., Terra L.F., Wailemann R.A., Oliveira T.C., Gomes V.M., Mineiro M.F., Meotti F.C., Bruni-Cardoso A., Baptista M.S., Labriola L. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. BMC Cancer. 2017; 17 (1): 194. DOI: 10.1186/s12885-017-3179-7.Bozzini G., Colin P., Betrouni N., Nevoux P., Ouzzane A., Puech P., Villers A., Mordon S. Photodynamic therapy in urology: what can we do now and where are we heading? Photodiagnosis Photodyn Ther. 2012; 9 (3): 261–273. DOI: 10.1016/j.pdpdt.2012.01.005.Civantos F.J., Karakullukcu B., Biel M., Silver C.E., Rinaldo A., Saba N.F., Takes R.P., Vander Poorten V., Ferlito A. A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. Adv Ther. 2018; 35 (3): 324–340. DOI: 10.1007/ s12325-018-0659-3.Коршунова О.В., Плехова Н.Г. Фотодинамическая терапия в онкологии: настоящее и будущее. Тихоокеанский медицинский журнал 2020; (4): 15–19. DOI: 10.34215/1609-1175-2020-4-15-19 / Korshunova O.V., Plekhova N.G. Photodynamic therapy in oncology: present and future. Pacific Medical Journal 2020; (4): 15–19. DOI: 10.34215/1609-1175-2020-4-15-19 (in Russian).Kolarikova M., Hosikova B., Dilenko H., Barton-Tomankova K., Valkova L., Bajgar R., Malina L., Kolarova H. Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments. Med Res Rev. 2023; 43 (4): 717–774. DOI: 10.1002/med.21935Батаев С.М., Циленко К.С., Осипов А.Н., Решетников А.В., Батаев А.С., Соснова С.П. Основы фотодинамической терапии, клиническая практика и перспективы применения в детской хирургии. Обзор литературы. Российский вестник детской хирургии, анестезиологии и реаниматологии 2023; 12 (4): 461–472. DOI: 10.17816/psaic936 / Bataev S.M., Cilenko K.S., Osipov A.N., Reshetnikov A.V., Bataev A.S., Sosnova S.P. Fundamentals of photodynamic therapy, clinical practice and prospects of application in pediatric surgery. Literature review. Russian Bulletin of Pediatric Surgery. Anesthesiology and Resuscitation 2023; 12 (4): 461–472. DOI: 10.17816/psaic936 (in Russian).Церковский Д.А., Протопович Е.Л., Ступак Д.С. Основные аспекты применения фотосенсибилизирующих агентов в фотодинамической терапии. Онкологический журнал. 2019; 13 (2): 79–99 / Tserkovskiy D.A., Prokopovich E.L., Stupak D.S. The main aspects of the use of photosensitizing agents in photodynamic therapy. Oncological Journal 2019; 13 (2), 79–99 (in Russian).Kwiatkowski S., Knap B., Przystupski D., Saczko J., Kędzierska E., Knap-Czop K., Kotlińska J., Michel O., Kotowski K., Kulbacka J. Photodynamic therapy – mechanisms, photosensitizers and combinations. Biomed Pharmacother. 2018; 106: 1098–1107. DOI:10.1016/j.biopha.2018.07.049.Meulemans J., Delaere P., Vander Poorten V. Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects. Curr Opin Otolaryngol Head NeckSurg. 2019; 27 (2): 136–141. DOI: 10.1097/MOO.0000000000000521.Mallidi S., Anbil S., Bulin A.L., Obaid G., Ichikawa M., Hasan T. Beyond the barriers of light penetration: strategies, perspectives and possibilities for photodynamic therapy. Theranostics. 2016; 6 (13): 2458–2487. DOI: 10.7150/thno.16183.Pogue B.W., Elliott J.T., Kanick S.C., Davis S.C., Samkoe K.S., Maytin E.V., Pereira S.P., Hasan T. Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success. Phys Med Biol. 2016; 61 (7): 57–89. DOI:10.1088/0031-9155/61/7/R57.Сажнев Д.И., Андреев А.А., Остроушко А.П. Фотодинамическая терапия в хирургической практике. Вестник экспериментальной и клинической хирургии 2019; 12: 2: 141–146. DOI: 10.18499/2070-478X-2019-12-2-141-146 / Sazhnev D.I., Andreev A.A., Ostroushko A.P. Photodynamic therapy in surgical practice. Bulletin of Experimental and Clinical Surgery 2019; 12: 2: 141–146. DOI: 10.18499/2070-478X-2019-12-2-141-146 (in Russian).Hodgkinson N., Kruger C.A., Abrahamse H. Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells. Tumour Biol. 2017; 39 (10): 1010428317734691. DOI: 10.1177/1010428317734691.Zhao X., Li M., Sun W., Fan J., Du J., Peng X. An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells. Chem Commun. 2018; 54: 7038–7041. DOI: 10.1039/C8CC03786H.Stuchinskaya T., Moreno M., Cook M.J., Edwards D.R., Russell D.A. Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates. Photochem Photobiol Sci. 2011; 10 (5): 822–831. DOI: 10.1039/c1pp05014a.Abrahamse H., Hamblin M.R. New photosensitizers for photodynamic therapy. Biochem J. 2016; 473 (4): 347–364. DOI: 10.1042/BJ20150942.Girard C., Debu A., Bessis D., Blatière V., Dereure O., Guillot B. Treatment of Gorlin syndrome (nevoid basal cell carcinoma syndrome) with methylaminolevulinate photodynamic therapy in seven patients, including two children: interest of tumescent anesthesia for pain control in children. J Eur Acad Dermatol Venereol. 2013; 27 (2): 171–175. DOI: 10.1111/j.1468-3083.2012.04538.x.Oseroff A.R., Shieh S., Frawley N.P., Cheney R., Blumenson L.E., Pivnick E.K., Bellnier D.A. Treatment of diffuse basal cell carcinomas and basaloid follicular hamartomas in nevoid basal cell carcinoma syndrome by wide-area 5-aminolevulinic acid photodynamic therapy. Arch Dermatol. 2005; 141 (1): 60–67. DOI: 10.1001/archderm.141.1.60.Loncaster J., Swindell R., Slevin F., Sheridan L., Allan D., Allan E. Efficacy of photodynamic therapy as a treatment for Gorlin syndrome-related basal cell carcinomas. Clin Oncol (R Coll Radiol). 2009; 21 (6): 502–508. DOI: 10.1016/j.clon.2009.03.004.Salvio A.G., Requena M.B., Stringasci M.D., Bagnato V.S. Photodynamic therapy as a treatment option for multiple pigmented basal cell carcinoma: Long-term follow-up results. Photodiagnosis Photodyn Ther. 2021; 33: 102154. DOI: 10.1016/j.pdpdt.2020.102154.Hyun D.J., Seo S.R., Kim D.H., Yoon M.S., Lee H.J. Periungual Bowen's Disease in a 12-Year-Old Boy Treated with Photodynamic Therapy. Pediatr Dermatol. 2016; 33 (2): 82–83. DOI: 10.1111/pde.12753.Xu M., Lin N., Li J., Jiang L., Zeng K. Photodynamic therapy as an alternative therapeutic option for pediatric condyloma acuminata: A case series. Photodiagnosis Photodyn Ther. 2018; 24: 179–181. DOI: 10.1016/j.pdpdt.2018.09.010Borgia F., Giuffrida R., Coppola M., Cannavò S.P. Successful photodynamic therapy in a pediatric patient with difficult warts. Dermatol Ther. 2020; 33 (3): 13391. DOI: 10.1111/dth.13391.Borgia F., Coppola M., Giuffrida R., Cannavò S.P. Excellent cosmetic result of daylight photodynamic therapy for facial flat warts in a child. Photodiagnosis Photodyn Ther. 2019; 26: 27–28. DOI: 10.1016/j.pdpdt.2019.02.021.Borgia F., Giuffrida R., Coppola M., Cannavò S.P. Successful photodynamic therapy in a pediatric patient with difficult warts. Dermatol Ther. 2020; 33 (3): e13391. DOI: 10.1111/dth.13391.Chun-Hua T., Li-Qiang G., Hua W., Jian Z., Si-Li N., Li L., Yi W., Can L., Xiao-Yan L., Guang-Hui W. Efficacy and safety of hemoporfin photodynamic therapy for port-wine stains in paediatric patients: A retrospective study of 439 cases at a single centre. Photodiagnosis Photodyn Ther. 2021; 36: 102568. DOI: 10.1016/j.pdpdt.2021.102568.Ding A., Li C., Zhang J. Topical 5-ami¬nolevulinic acid photodynamic therapy in the treatment of verruca plana: Report of 6 cases. Photodiagnosis Photodyn Ther. 2021; 35: 102438. DOI: 10.1016/j.pdpdt.2021.102438.Chen M., Xie J., Han J. Photodynamic therapy of condyloma acuminatum in a child. Pediatr Dermatol. 2010; 27 (5): 542–544. DOI: 10.1111/j.1525-1470.2010.01279.x.Белышева Т.С., Моисеенко Е. Лазерная терапия сосудистых образований кожи у детей. Саркомы костей, мягких тканей и опухоли кожи. 2011; (3): 37–47 / Belysheva T.S., Moiseenko E. Laser therapy of vascular skin formations in children. Sarcomas of bones, soft tissues and skin tumors 2011; (3): 37–47 (in Russian).Chun-Hua T., Li-Qiang G., Hua W., Jian Z., Si-Li N., Li L., Yi W., Can L., Xiao-Yan L., Guang-Hui W. Efficacy and safety of hemoporfin photodynamic therapy for port-wine stains in paediatric patients: A retrospective study of 439 cases at a single centre. Photodiagnosis Photodyn Ther. 2021; 36: 102568. DOI: 10.1016/j.pdpdt.2021.102568.Huang Y., Yang J., Sun L., Zhang L., Bi M. Efficacy of influential factors in hemoporfin-mediated photodynamic therapy for facial port-wine stains. J Dermatol. 2021; 48 (11): 1700–1708. DOI: 10.1111/1346-8138.16094.Wang S., Lee L.Y., Liu S.X. Photodynamic therapy for port-wine stains in extremities: Report of 4 cases. Photodiagnosis Photodyn Ther. 2020; 30: 101781. DOI: 10.1016/j.pdpdt.2020.101781.Xiao Q., Li Q., Yuan K.H., Cheng B. Photodynamic therapy of port-wine stains: long-term efficacy and complication in Chinese patients. J Dermatol. 2011; 38 (12): 1146–1152. DOI: 10.1111/j.1346-8138.2011.01292.x.Cai H., Yang Q.Q., Ma C., Zou D.X., Wang Y.X., Sun P., Ju A.Q., Fang F., Gong S., Liu W. Photodynamic therapy in the treatment of xeroderma pigmentosum: A case report. Photodiagnosis Photodyn Ther. 2020; 30: 101761. DOI: 10.1016/j.pdpdt.2020.101761.Li Y., Wang X., Liu Y., Tao J. Dermoscopy predicts outcome in hemoporfin-me¬diated photodynamic therapy of port-wine stains: A prospective observational study. J Am Acad Dermatol. 2020; 83 (6): 1765–1767. DOI: 10.1016/j.jaad.2020.03.063.Мишутина О.Л., Волченкова Г.В., Ковалева Н.С., Васильцова О.А., Фахрадова В.А. Фотодинамическая терапия в стоматологии (обзор литературы). Смоленский медицинский альманах 2019; (3): 102–111 / Mishutina O.L., Volchenkova G.V., Kovaleva N.S., Vasil'cova O.A., Fahradova V.A. Photodynamic therapy in dentistry (literature review). Smolensk Medical Almanac 2019; (3): 102–111 (in Russian).Alsaif A., Tahmassebi J.F., Wood S.R. Treatment of dental plaque biofilms using photodynamic therapy: a randomised controlled study. Eur Arch Paediatr Dent. 2021; 22 (5): 791–800. DOI: 10.1007/s40368-021-00637-y.Bargrizan M., Fekrazad R., Goudarzi N., Goudarzi N. Effects of antibacterial photodynamic therapy on salivary mutans streptococci in 5- to 6-year-olds with severe early childhood caries. Lasers Med Sci. 2019; 34 (3): 433–440. DOI: 10.1007/s10103-018-2650-2652.Rosa E.P., Murakami-Malaquias-Silva F., Schalch T.O., Teixeira D.B., Horliana R.F., Tortamano A., Tortamano I.P., Buscariolo I.A., Longo P.L., Negreiros R.M., Bussadori S.K., Motta L.J., Horliana A.C.R.T. Efficacy of photodynamic therapy and periodontal treatment in patients with gingivitis and fixed orthodontic appliances: Protocol of randomized, controlled, double-blind study. Medicine (Baltimore). 2020; 99 (14): 19429. DOI: 10.1097/MD.0000000000019429.Luke-Marshall N.R., Hansen L.A., Shafirstein G., Campagnari A.A. Antimicrobial Photodynamic Therapy with Chlorin e6 Is Bactericidal against Biofilms of the Primary Human Otopathogens. mSphere. 2020; 5 (4): e00492-20. DOI:10.1128/mSphere.00492-20.Кисельникова Л.П., Кузнецова Г.И. Применение фотодинамической терапии при лечении гингивита в детском возрасте. Клиническая стоматология 2016; 2 (78):4–8 / Kiselnikova L.P., Kuznetsova G.I. Application of photodynamic therapy in the treatment of gingivitis in childhood. Clinical dentistry 2016; 2 (78): 4–8 (in Russian).Okamoto C.B., Motta L.J., Prates R.A., da Mota A.C.C., Gonçalves M.L.L., Horliana A.C.R.T., Mesquita Ferrari R.A., Fernandes K.P.S., Bussadori S.K. Antimicrobial Photodynamic Therapy as a Co-adjuvant in Endodontic Treatment of Deciduous Teeth: Case Series. Photochem Photobiol. 2018; 94 (4): 760–764. DOI: 10.1111/php.12902.Караков К.Г., Хачатурян Э.Э., Узденов М.Б., Узденова Л.Х., Хачатурян А.Э., Еременко А.В., Уснунц Ю.К. Cовременный взгляд на антибактериальную обработку корневого канала с помощью лазерной фотодинамической терапии. Проблемы стоматологии 2019; 15 (1): 23–27. DOI: 10.18481/2077-7566-2018-15-1-23-27 / Karakov K.G., Hachaturyan E.E., Uzdenov M.B., Uzdenova L.H., Hachaturyan A.E., Eremenko A.V., Usnunc YU.K. A modern look at the antibacterial treatment of the root canal using laser photodynamic therapy. Problemy stomatologii 2019; 15 (1): 23–27. DOI: 10.18481/2077-7566-2018-15-1-23-27 (in Russian).Pinheiro S.L., Schenka A.A., Neto A.A., de Souza C.P., Rodriguez H.M., Ribeiro M.C. Photodynamic therapy in endodontic treatment of deciduous teeth. Lasers Med Sci. 2009; 24 (4): 521–526. DOI: 10.1007/s10103-008-0562-2.Malik N.K.A., Alkadhi O.H. Effectiveness of mechanical debridement with and without antimicrobial photodynamic therapy against oral yeasts in children with gingivitis undergoing fixed orthodontic therapy. Photodiagnosis Photodyn Ther. 2020; 31: 101768. DOI: 10.1016/j.pdpdt.2020.101768.Ribeiro da Silva V.C., da Motta Silveira F.M., Barbosa Monteiro M.G., da Cruz M.M.D., Caldas Júnior A.F., Pina Godoy G. Photodynamic therapy for treatment of oral mucositis: Pilot study with pediatric patients undergoing chemotherapy. Photodiagnosis Photodyn Ther. 2018; 21: 115–120. DOI: 10.1016/j.pdpdt.2017.11.010.de Sant'Anna G. Photodynamic therapy for the endodontic treatment of a traumatic primary tooth in a diabetic pediatric patient. J Dent Res Dent Clin Dent Prospects. 2014; 8 (1): 56–60. DOI: 10.5681/joddd.2014.010.da Mota A.C., Gonçalves M.L., Bortoletto C., Olivan S.R., Salgueiro M., Godoy C., Altavista O.M., Pinto M.M., Horliana A.C., Motta L.J., Bussadori S.K. Evaluation of the effectiveness of photodynamic therapy for the endodontic treatment of primary teeth: study protocol for a randomized controlled clinical trial. Trials. 2015; 16: 551. DOI: 10.1186/s13063-015-1086-2.Fekrazad R., Seraj B., Chiniforush N., Rokouei M., Mousavi N., Ghadimi S. Effect of antimicrobial photodynamic therapy on the counts of salivary Streptococcus mutans in children with severe early childhood caries. Photodiagnosis Photodyn Ther. 2017; 18: 319–322. DOI: 10.1016/j.pdpdt.2017.03.007.Alves L.V.G.L., Curylofo-Zotti F.A., Borsatto M.C., Salvador S.L.S., Valério R.A., Souza-Gabriel A.E., Corona S.A.M. Influence of antimicrobial photodynamic therapy in carious lesion. Randomized split-mouth clinical trial in primary molars. Photodiagnosis Photodyn Ther. 2019; 26: 124–130. DOI: 10.1016/j.pdpdt.2019.02.018.Potapchuk A.M., Almashi V.M., Lomnitsky I.Y., Rusyn V.V., Hegedush V. The use of photodynamic therapy in the treatment of dental caries in children of contaminated areas of the ecosystem of the upper tysa region. Wiad Lek. 2020; 73 (3): 483–488.Carvalho L.T., Belém F.V., Gonçalves L.M., Bussadori S.K., Paschoal M.A.B. Chemo-mechanical and photodynamic approach in A deep dental cavity: A case report. Photodiagnosis Photodyn Ther. 2020; 32: 101954. DOI: 10.1016/j.pdpdt.2020.101954.Рябова М.А., Молодцова В.П., Портнов Г.B., Акопов А.Л. Рецидивирующий респираторный папилломатоз с вовлечением легких и малигнизацией. Пульмонология 2022; 32 (2): 261–269. DOI: 10.18093/0869-0189-2022-32-2-261-269 / Ryabova M.A., Molodcova V.P., Portnov G.B., Akopov A.L. Recurrent respiratory papillomatosis with lung involvement and malignancy. Pulmonology 2022; 32 (2): 261–269. DOI: 10.18093/0869-0189-2022-32-2-261-269 (in Russian).Lieder A., Khan M.K., Lippert B.M. Photodynamic therapy for recurrent respiratory papillomatosis. Cochrane Database Syst Rev. 2014; (6): CD009810. DOI: 10.1002/14651858.CD009810.pub2.Shikowitz M.J., Abramson A.L., Steinberg B.M., DeVoti J., Bonagura V.R., Mullooly V., Nouri M., Ronn A.M., Inglis A., McClay J., Freeman K. Clinical trial of photodynamic therapy with meso-tetra (hydroxyphenyl) chlorin for respiratory papillomatosis. Arch Otolaryngol Head Neck Surg. 2005; 131 (2): 99–105. DOI: 10.1001/archotol.131.2.99.Иойлева Е.Э., Белянина С.И. Лечение хориоидальной неоваскуляризации, ассоциированной с друзами диска зрительного нерва. Российская детская офтальмология 2022; 3: 51–57 / Ioyleva E.E., Belyanina S.I. Treatment of choroidal neovascularization associated with optic disc druses. Rossijskaya detskaya oftalmologiya 2022; 3: 51–57 (in Russian).Ozdek S., Ozmen M.C., Tufan H.A., Gurelik G., Hasanreisoglu B. Photodynamic therapy for best disease complicated by choroidal neovascularization in children. J Pediatr Ophthalmol Strabismus. 2012; 49 (4): 216–21. DOI: 10.3928/01913913-20111004-01.Lipski A., Bornfeld N., Jurklies B. Photodynamic therapy with verteporfin in paediatric and young adult patients: long-term treatment results of choroidal neovascularisations. Br J Ophthalmol. 2008; 92 (5): 655–660. DOI: 10.1136/bjo.2007.134429.Süsskind D., Inhoffen W., Gelisken F., Völker M. Photodynamic therapy with double duration for circumscribed choroidal haemangioma: functional and anatomical results based on initial parameters. Clin Exp Ophthalmol. 2018; 46 (5): 495–501. DOI:10.1111/ceo.13096.Yıldırım C., Çetin E.N., Yayla K., Avunduk A.M., Yaylalı V. Photodynamic therapy for unilateral idiopathic peripapillary choroidal neovascularization in a child. Int Ophthalmol. 2011; 31 (4): 333–335. DOI: 10.1007/s10792-011-9442-z.Giansanti F., Virgili G., Varano M., Tedeschi M., Rapizzi E., Giacomelli G., Menchini U. Photodynamic therapy for choroidal neovascularization in pediatric patients. Retina. 2005; 25 (5): 590–696. DOI: 10.1097/00006982-200507000-00009.Ольшанская А.С., Шнайдер Н.А., Дмитренко Д.В., Козина Е.В., Чешейко Е.Ю., Ильенков С.С., Цуприкова М.Е. Поражение органа зрения при синдроме Штурге-Вебера. Забайкальский медицинский вестник. 2019; (2): 196–203 / Ol'shanskaya A.S., SHnajder N.A., Dmitrenko D.V., Kozina E.V., CHeshejko E.YU., Il'enkov S.S., Cuprikova M.E. Damage to the organ of vision in Sturge-Weber syndrome. Zabajkalskij medicinskij vestnik 2019; (2): 196–203 (in Russian).Nugent R., Lee L., Kwan A. Photodynamic therapy for diffuse choroidal hemangioma in a child with Sturge-Weber syndrome. J AAPOS. 2015; 19 (2): 181–183. DOI: 10.1016/j.jaapos.2014.10.032.Mauget-Faÿsse M., Mimoun G., RuizMoreno J.M., Quaranta-El Maftouhi M., De Laey J.J., Postelmans L., Soubrane G., Defauchy M., Leys A. Verteporfin photodynamic therapy for choroidal neovascularization associated with toxoplasmic retinochoroiditis. Retina. 2006; 26 (4): 396–403. DOI: 10.1097/01.iae.0000238552.76412.ae.Farah M.E., Costa R.A., Muccioli C., Guia T.A., Belfort R.Jr. Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 2002; 134 (1): 137–139. DOI: 10.1016/s0002-9394(02)01456-3.Schwake M., Nemes A., Dondrop J., Schroeteler J., Schipmann S., Senner V., Stummer W., Ewelt C. In-Vitro Use of 5-ALA for Photodynamic Therapy in Pediatric Brain Tumors. Neurosurgery. 2018; 83 (6): 1328–1337. DOI: 10.1093/neuros/nyy054.Schmidt M.H., Meyer G.A., Reichert K.W., Cheng J., Krouwer H.G., Ozker K., Whelan H.T. Evaluation of photodynamic therapy near functional brain tissue in patients with recurrent brain tumors. J Neurooncol. 2004; 67 (1–2): 201–207. DOI: 10.1023/b: neon.0000021804.50002.85.Lou P.J., Jäger H.R., Jones L., Theodossy T., Bown S.G., Hopper C. Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer. Br J Cancer. 2004; 91 (3): 441–446. DOI: 10.1038/sj.bjc.6601993.Yu W., Zhu J., Wang Y., Wang J., Fang W., Xia K., Shao J., Wu M., Liu B., Liang C., Ye C., Tao H. A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep. Oncotarget. 2017; 8 (24): 39833–39848. DOI: 10.18632/oncotarget.Маркичев Н.А., Елисеенко В.И., Алексеев Ю.В., Армичев А.А. Фотодинамическая терапия базальноклеточного рака кожи с применением фотосенсибилизатора хлоринового ряда. Лазерная медицина 2005; 9 (1): 16–19 / Markichev N.A., Eliseenko V.I., Alekseev YU.V., Armichev A.A. Photodynamic therapy of basal cell skin cancer with the use of a photosensitizer of the chlorin series. Laser medicine 2005; 9 (1): 16–19 (in Russian).Esposito S., Garziano M., Rainone V., Trabattoni D., Biasin M., Senatore L., Marchisio P., Rossi M., Principi N., Clerici M. Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia. J Transl Med. 2015; 13: 288. DOI: 10.1186/s12967-015-0649-z.Nicolò M., Desideri L.F., Vagge A., Traverso C.E. Current Pharmacological Treatment Options for Central Serous Chorioretinopathy: A Review. Pharmaceuticals (Basel). 2020; 13 (10): 264. DOI: 10.3390/ph13100264.Seitz G., Fuchs J., Schaefer J.F., Warmann S.W. Molecular imaging and photodynamic therapy in hepatoblastoma. Front Biosci (Elite Ed). 2012; 4 (1): 487–492. DOI: 10.2741/e394.Stefini A., Salzer S., Reich G., Horn H., Winkelmann K., Bents H., Rutz U., Frost U., von Boetticher A., Ruhl U., Specht N., Kronmüller K.T. Cognitive-Behavioral and Psychodynamic Therapy in Female Adolescents With Bulimia Nervosa: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2017; 56 (4): 329–335. DOI: 10.1016/j.jaac.2017.01.019.