A clinical case of HIV-associated Kaposi's sarcoma with skin and lung lesions is presented. A patient referred to the Perm Regional Center for the Prevention and Control of AIDS and Infectious Diseases complaining of rash on the skin of the right wing of the nose, forehead, in the right axillary and right inguinal areas, on the shins. The first skin changes occurred in December 2020 on the right wing of the nose, later the pathological process spread to other areas of the skin. HIV was revealed in 2009 and the patient had not received specialized medical care until 2022 as he had been in prison. Since March 2022, the patient has been registered at the dispensary and regularly receives antiretroviral therapy. In April 2022, PET/CT tests and histological examination of a biopsy of skin rashes were performed. On the basis of these findings the diagnosis of Kaposi's sarcoma with skin and lungs lesions was made.

HIV-associated Kaposi's sarcoma is accompanied by lesions of the skin and internal organs. Skin changes in Kaposi's sarcoma are characterized by the primary localization of foci on the face and upper extremities, and without antiretroviral therapy, by rapid progression and generalization of the pathological process. Visceral lesions worsen the course of the disease and complicate its prognosis. Patients with HIV-associated Kaposi's sarcoma need dynamic monitoring and complex therapy from infectious diseases specialists, dermatovenerologists, oncologists.