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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Perm Medical Journal</journal-id><journal-title-group><journal-title xml:lang="en">Perm Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Пермский медицинский журнал (сетевое издание "Perm medical journal")</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0136-1449</issn><issn publication-format="electronic">2687-1408</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">633290</article-id><article-id pub-id-type="doi">10.17816/pmj42112-19</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Literature review</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic heart failure with preserved ejection fraction: current understanding of the problem</article-title><trans-title-group xml:lang="ru"><trans-title>Хроническая сердечная недостаточность с сохраненной фракцией выброса: современные представления о проблеме</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4835-2666</contrib-id><name-alternatives><name xml:lang="en"><surname>Ponomareva</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Пономарева</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Postgraduate Student, Assistant of the Department of Faculty Therapy no. 1</p></bio><bio xml:lang="ru"><p>аспирант, ассистент кафедры факультетской терапии № 1</p></bio><email>sovpel_olga@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6451-9045</contrib-id><name-alternatives><name xml:lang="en"><surname>Vladimirsky</surname><given-names>V. Е.</given-names></name><name xml:lang="ru"><surname>Владимирский</surname><given-names>В. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>DSc (Medicine), Head of the Department of Faculty Therapy no. 1</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, заведующий кафедрой факультетской терапии № 1</p></bio><email>sovpel_olga@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7328-7537</contrib-id><name-alternatives><name xml:lang="en"><surname>Petukhova</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Петухова</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (Medicine), Associate Professor of the Department of Faculty Thera­py no. 1</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры факультетской терапии № 1</p></bio><email>sovpel_olga@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ye.A. Vagner Perm State Medical University</institution></aff><aff><institution xml:lang="ru">Пермский государственный медицинский университет имени академика Е.А. Вагнера</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-02-12" publication-format="electronic"><day>12</day><month>02</month><year>2025</year></pub-date><volume>42</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2024-06-06"><day>06</day><month>06</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://permmedjournal.ru/PMJ/article/view/633290">https://permmedjournal.ru/PMJ/article/view/633290</self-uri><abstract xml:lang="en"><p>This review is aimed at the investigation of diagnostic approaches and therapeutic options for patients with chronic cardiac insufficiency with preserved ejection fraction.</p> <p>Chronic cardiac insufficiency with preserved ejection fraction can result from various cardiovascular diseases and is observed in more than 50 % of patients with chronic circulatory failure. Although clinical guidelines exist, the criteria for diagnosing this form of heart failure do not always allow to detect the disease accurately, which can affect subsequent treatment negatively. Modern randomized clinical trials demonstrate that medications from the group of sodium-glucose cotransporter type-2 inhibitors significantly improve clinical outcomes in patients with circulatory failure, justifying their inclusion in treatment regimen. However, the optimal time for starting this therapy is still questionable compared to the administration of other medications recommended for chronic cardiac insufficiency.</p> <p>Considering high incidence, difficulties in diagnosis and treatment for circulatory failure with preserved ejection fraction in practice, the development of practical algorithms for detecting and managing this condition is one of the most important tasks.</p></abstract><trans-abstract xml:lang="ru"><p>Исследованы подходы к диагностике и лечебные возможности для пациентов с хронической сердечной недостаточностью с сохраненной фракцией выброса.</p> <p>Хроническая сердечная недостаточность с сохраненной фракцией выброса может быть следствием различных заболеваний сердечно-сосудистой системы и наблюдается более чем у 50 % пациентов с хронической недостаточностью кровообращения. Хотя существуют клинические рекомендации, критерии диагностики этой формы недостаточности кровообращения не всегда позволяют точно выявить заболевание, что может негативно сказаться на дальнейшем лечении.</p> <p>Современные рандомизированные клинические исследования показывают, что препараты из группы ингибиторов натрий-глюкозного котранспортера 2-го типа существенно улучшают клинические исходы у пациентов с недостаточностью кровообращения, что обосновывает их включение в лечебную схему. Однако все еще остаются вопросы относительно оптимального времени начала этой терапии по сравнению с назначением других рекомендованных препаратов для лечения ХСН.</p> <p>Принимая во внимание высокую распространённость, возникающие сложности диагностики и лечения недостаточности кровообращения с сохраненной фракцией выброса в практике, создание удобных для применения алгоритмов обнаружения и ведения этого заболевания представляется одной из наиболее важных задач.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic cardiac insufficiency with preserved ejection fraction</kwd><kwd>diagnosis</kwd><kwd>pharmacological treatment</kwd><kwd>sodium-glucose cotransporter type-2 inhibitors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность с сохраненной фракцией выброса</kwd><kwd>диагностика</kwd><kwd>медикаментозное лечение</kwd><kwd>ингибиторы натрий-глюкозного котранспортера 2-го типа</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>James S.L. et al. 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