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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Perm Medical Journal</journal-id><journal-title-group><journal-title xml:lang="en">Perm Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Пермский медицинский журнал (сетевое издание "Perm medical journal")</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0136-1449</issn><issn publication-format="electronic">2687-1408</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">634700</article-id><article-id pub-id-type="doi">10.17816/pmj422121-129</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Случай из практики</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A clinical case of right ventricular myocardial infarction in a patient with diabetes mellitus and Fahr’s disease</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай инфаркта миокарда правого желудочка у пациента с сахарным диабетом и болезнью Фара</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0783-8709</contrib-id><name-alternatives><name xml:lang="en"><surname>Yashin</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Яшин</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Senior Lecturer</p></bio><bio xml:lang="ru"><p>старший преподаватель кафедры общей и клинической патологии</p></bio><email>s.s.yashin@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8764-7955</contrib-id><name-alternatives><name xml:lang="en"><surname>Isakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Исакова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (Medicine), Associate Professor of the Department of General and Clinical Pathology</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры общей и клинической патологии</p></bio><email>s.s.yashin@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7282-2416</contrib-id><name-alternatives><name xml:lang="en"><surname>Anisimov</surname><given-names>S. O.</given-names></name><name xml:lang="ru"><surname>Анисимов</surname><given-names>С. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student of the Institute of Clinical Medicine</p></bio><bio xml:lang="ru"><p>студент Института клинической медицины</p></bio><email>s.s.yashin@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7412-5062</contrib-id><name-alternatives><name xml:lang="en"><surname>Yevgrafova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Евграфова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student of the Institute of Clinical Medicine</p></bio><bio xml:lang="ru"><p>студентка Института клинической медицины</p></bio><email>s.s.yashin@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">Самарский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-04-20" publication-format="electronic"><day>20</day><month>04</month><year>2025</year></pub-date><volume>42</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>121</fpage><lpage>129</lpage><history><date date-type="received" iso-8601-date="2024-08-08"><day>08</day><month>08</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://permmedjournal.ru/PMJ/article/view/634700">https://permmedjournal.ru/PMJ/article/view/634700</self-uri><abstract xml:lang="en"><p>Right ventricular myocardial infarction (RVMI) is quite a rare and difficult to diagnose disease. The leading method in the diagnosis of RVMI is a standard electrocardiography (ECG) in 12 leads, but a reliable establishment of this pathology is possible only with the use of mirror-image right precordial leads. In the presented clinical case, a 68-year-old patient was admitted to the hospital with complaints of weakness in the right extremities, speech impairment, nausea and vomiting. A complete examination was carried out and conservative treatment was initiated. Despite the treatment being administered, the patient's condition continued to deteriorate progressively, and therefore it was decided to transfer the patient to the intensive care unit, where an ECG revealed the likelihood of ischemia of the anterolateral and lower walls. The next day, respiratory and cardiac arrest was diagnosed, and resuscitation measures had no effect. During autopsy, cardiomyocyte necrosis zones with perifocal inflammation were found in the myocardium of the right ventricle, corresponding to myocardial infarction within 6 to 12 hours. Clinical observation emphasizes the importance of timely diagnosis of RVMI, especially against the background of severe metabolic disorders in the organism caused by diabetes mellitus.</p></abstract><trans-abstract xml:lang="ru"><p>Инфаркт миокарда правого желудочка (ИМ ПЖ) является достаточно редким и диагностически сложным заболеванием. Ведущим методом в диагностике ИМ ПЖ является стандартная электрокардиография (ЭКГ) в 12 отведениях, но достоверно судить о данной патологии возможно только с применением зеркальных правых грудных отведений. В представленном клиническом случае пациент в возрасте 68 лет поступил в стационар с жалобами на слабость в правых конечностях, нарушение речи, тошноту, рвоту. Было проведено обследование в полном объеме, начато консервативное лечение. Несмотря на проводимую терапию, состояние больного продолжало прогрессивно ухудшаться; было принято решение о переводе в отделение реанимации и интенсивной терапии, где при проведении ЭКГ выявлялись вероятность ишемии переднебоковой и нижней стенок. На следующий день была диагностирована остановка дыхания и сердечной деятельности, реанимационные мероприятия без эффекта. При аутопсии в миокарде правого желудочка были обнаружены зоны некроза кардиомиоцитов с перифокальным воспалением, соответствующие инфаркту миокарда сроком от 6 до 12 ч. Клиническое наблюдение подчеркивает важность своевременной диагностики ИМ ПЖ, особенно на фоне тяжелых метаболических нарушений в организме вследствие сахарного диабета.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Right ventricular myocardial infarction</kwd><kwd>acute coronary syndrome</kwd><kwd>coronary heart disease</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>Fahr’s disease</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфаркт миокарда правого желудочка</kwd><kwd>острый коронарный синдром</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>сахарный диабет 2-го типа</kwd><kwd>болезнь Фара</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Mozaffarian D., Benjamin E.J., Go A.S. et al. American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Heart disease and stroke statistics-2016 update: A report from the American Heart Association. Circulation 2016; 133 (4): e38–360. DOI: 10.1161/CIR.0000000000000350</mixed-citation><mixed-citation xml:lang="ru">Mozaffarian D., Benjamin E.J., Go A.S. et al. American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation 2016; 133 (4): e38–360. DOI: 10.1161/CIR.0000000000000350</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Andersen H.R., Falk E., Nielsen D. Right ventricular infarction: frequency, size and topography in coronary heart disease: a prospective study comprising 107 consecutive autopsies from a coronary care unit. J. Am. Coll. Cardiol. 1987; 10 (6): 1223–1232. DOI: 10.1016/s0735-1097(87)80122-5</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Starr I., Jeffers W.A., Meade R.H. The absence of conspicuous increments of venous pressure after severe damage to the right ventricle of the dog with a discussion of the relation between clinical congestive failure and heart disease. Am. Heart. J. 1943; 26: 291–301. DOI: 10.1016/S0002-8703(43)90325-4</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Sanders A.O. Coronary thrombosis with complete heart-block and relative ventricular tachycardia a case report. Am. Heart. J. 1931; 6: 820–823.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Cohn J.N., Guiha N.H., Broder M.I., Limas C.J. Right ventricular infarction. Clinical and hemodynamic features. Am. J. Cardiol. 1974; 33 (2): 209–214. DOI: 10.1016/0002-9149(74)90276-8</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kinch J.W., Ryan T.J. Right ventricular infarction. N. Engl. J. Med. 1994; 330 (17): 1211–1217. DOI: 10.1056/NEJM199404283301707</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Dell'Italia L.J., Starling M.R., O'Rourke R.A. Physical examination for exclusion of hemodynamically important right ventricular infarction. Ann. Intern. Med. 1983; 99 (5): 608–611. DOI: 10.7326/0003-4819-99-5-608</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Dell'Italia L.J., Starling M.R., Crawford M.H., Boros B.L., Chaudhuri T.K., O'Rourke R.A. Right ventricular infarction: identification by hemodynamic measurements before and after volume loading and correlation with noninvasive techniques. J. Am. Coll. Cardiol. 1984; 4 (5): 931–939. DOI: 10.1016/s0735-1097(84)80053-4</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Cintron G.B., Hernandez E., Linares E., Aranda J.M. Bedside recognition, incidence and clinical course of right ventricular infarction. Am. J. Cardiol. 1981; 47 (2): 224–227. DOI: 10.1016/0002-9149(81)90389-1</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Zehender M., Kasper W., Kauder E., Schönthaler M., Geibel A., Olschewski M., Just H. Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. N. Engl. J. Med. 1993; 328 (14): 981–988. DOI: 10.1056/NEJM199304083281401</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Fijewski T.R., Pollack M.L., Chan T.C., Brady W.J. Electrocardiographic manifestations: right ventricular infarction. J. Emerg. Med. 2002; 22 (2): 189–194. DOI: 10.1016/s0736-4679(01)00463-2</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Birnbaum Y., Sclarovsky S., Mager A., Strasberg B., Rechavia E. ST segment depression in aVL: a sensitive marker for acute inferior myocardial infarction. Eur. Heart J. 1993; 14 (1): 4–7. DOI: 10.1093/eurheartj/14.1.4</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Saw J., Davies C., Fung A., Spinelli J.J., Jue J. Value of ST elevation in lead III greater than lead II in inferior wall acute myocardial infarction for predicting in-hospital mortality and diagnosing right ventricular infarction. Am. J. Cardiol. 2001; 87 (4): 448–450, A6. DOI: 10.1016/s0002-9149(00)01401-6</mixed-citation></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Yashin S.S., Yunusova Yu.R., Isakova N.V., Larina T.V., Mikhailova Yu.V., Ivanova E.A., Elfimov I.V. Fahr's disease in a patient with acute cerebrovascular accident. Modern Problems of Science and Education 2020; (6): 188. DOI: 10.17513/spno.30457 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Яшин С.С., Юнусова Ю.Р., Исакова Н.В., Ларина Т.В., Михайлова Ю.В., Иванова Е.А., Елфимов И.В. Болезнь Фара у пациентки с острым нарушением мозгового кровообращения. Современные проблемы науки и образования 2020; (6): 188. DOI: 10.17513/spno.30457 / Yashin S.S., Yunusova Yu.R., Isakova N.V., Larina T.V., Mikhailova Yu.V., Ivanova E.A., Elfimov I.V. Fahr's disease in a patient with acute cerebrovascular accident. Modern Problems of Science and Education 2020; (6): 188. DOI: 10.17513/spno.30457 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><mixed-citation>Carbone M.G., Della Rocca F. Neuropsychiatric manifestations of Fahr's disease, diagnostic and therapeutic challenge: A Case Report and a Literature Review. Clin Neuropsychiatry 2022; 19 (2): 121–131. DOI: 10.36131/cnfioritieditore20220206</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Li Y., Liu Y., Liu S., Gao M., Wang W., Chen K., Huang L., Liu Y. Diabetic vascular diseases: molecular mechanisms and therapeutic strategies. Signal Transduct Target Ther. 2023; 8 (1): 152. DOI: 10.1038/s41392-023-01400-z</mixed-citation></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Basantsova N.Yu., Shishkin A.N., Tibekina L.M. Cerebrocardial syndrome and its features in patients with acute cerebrovascular accidents. Bulletin of St. Petersburg University. Medicine 2017; 12 (1): 31–47 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Басанцова Н.Ю., Шишкин А.Н., Тибекина Л.М. Цереброкардиальный синдром и его особенности у пациентов с острыми нарушениями мозгового кровообращения. Вестник Санкт-Петербургского университета. Медицина 2017; 12 (1): 31–47. / Basantsova N.Yu., Shishkin A.N., Tibekina L.M. Cerebrocardial syndrome and its features in patients with acute cerebrovascular accidents. Bulletin of St. Petersburg University. Medicine 2017; 12 (1): 31–47 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Yashin S.S., Kireeva A.O., Sukhachev P.A. Stress-induced cardiomyopathy (takotsubo syndrome). Innovative Medicine of Kuban 2023; 8 (1): 111–115 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Яшин С.С., Киреева А.О., Сухачев П.А. Стресс-индуцированная кардиомиопатия (синдром такоцубо). Инновационная медицина Кубани 2023; 8 (1): 111–115. / Yashin S.S., Kireeva A.O., Sukhachev P.A. Stress-induced cardiomyopathy (takotsubo syndrome). Innovative Medicine of Kuban 2023; 8 (1): 111–115 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Slatova L.N., Fedorina T.A., Bormotov A.V., Samychin M.Yu., Buklesheva I.M. Morphological characteristics of coronary and carotid atherosclerotic plaques in patients with myocardial infarction. Science and Innovations in Medicine 2017; 2 (6): 15–19 (in Russian).</mixed-citation><mixed-citation xml:lang="ru">Слатова Л.Н., Федорина Т.А., Бормотов А.В., Самычин М.Ю., Буклешева И.М. Морфологическая характеристика атеросклеротических бляшек коронарных и сонных артерий у пациентов с инфарктом миокарда. Наука и инновации в медицине 2017; 2 (6): 15–19. / Slatova L.N., Fedorina T.A., Bormotov A.V., Samychin M.Yu., Buklesheva I.M. Morphological characteristics of coronary and carotid atherosclerotic plaques in patients with myocardial infarction. Science and Innovations in Medicine 2017; 2 (6): 15–19 (in Russian).</mixed-citation></citation-alternatives></ref></ref-list></back></article>
