Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector6430910.17816/pmj38418-24Research ArticleFrequency of endemic goiter and indicators of pituitary-thyroid profile in Arctic childrenEvseevaS. A.<p>Candidate of Medical Sciences, senior researcher</p>bourtsevat@yandex.ruBurtsevaT. E.<p>MD, PhD, Professor, Department of Pediatrics and Pediatric Surgery</p>bourtsevat@yandex.ruhttps://orcid.org/0000-0002-5490-2072KlimovaT. M.<p>Candidate of Medical Sciences, Associate Professor, Department of Pharmacology</p>bourtsevat@yandex.ruDanilovN. A.<p>postgraduate student</p>bourtsevat@yandex.ruChasnykV. G.<p>MD, PhD, Head of Department of Hospital Pediatrics</p>bourtsevat@yandex.ruDouglasN. I.<p>MD, PhD, Head of Department of Obstetrics and Gynecology</p>bourtsevat@yandex.ruYakut Scientific Center for Complex Medical ProblemsNorth-Eastern Federal University named after M. K. AmmosovSaint Petersburg State Pediatric Medical University15082021384182430032021Copyright © 2021, Evseeva S.A., Burtseva T.E., Klimova T.M., Danilov N.A., Chasnyk V.G., Douglas N.I.2021<p><strong>Objective.</strong> Analysis of the frequency of endemic goiter and indicators of the pituitary-thyroid profile in children aged 10-18 years living in the Arctic regions of Yakutia.</p>
<p><strong>Materials and methods.</strong> The study was conducted among children and adolescents of the Arctic regions of Yakutia (Bulunsky, Anabarsky, Allaikhovsky, Nizhnekolymsky, Verkhnekolymsky district) during field medical expeditions in 20182020. A total of 392 children aged 1018 years were examined.</p>
<p><strong>Results.</strong> In 30 % of the examined children, an increase in the thyroid gland was observed, which was accompanied by elevated levels of free thyroxine. In 3 % of children, an increase in the level of thyroid-stimulating hormone was detected against the background of reduced or normal levels of free thyroxine.</p>
<p><strong>Conclusions. </strong>As for the prevalence of cases of endemic goiter, the Arctic regions of Yakutia are the areas of severe goiter endemia. The results obtained justify the need for additional scientific studies to assess the degree of iodine availability (by the concentration of iodine in the urine) in different population groups and real implementation of the strategy of mass preventive measures.</p>endemic goiterhormonespituitary glandthyroid glandthyroid profilechildrenYakutiaArcticэндемический зобгормоныгипофизщитовидная железатиреоидный профильдетиЯкутияАрктика[Vanderpump M.P. Epidemiology of iodine deficiency. Minerva Med 2017; 108 (2): 116–123.][Zimmermann M.B., Jooste P.L., Pandav C.S. Iodine-deficiency disorders. Lancet (London, England) 2008; 372 (9645): 1251–1262.][Li M., Eastman C.J. The changing epidemiology of iodine deficiency. Nat Rev Endocrino. 2012; 8 (7): 434–440.][Alferova V.I., Mustafina S.V., Rymar O.D. Iodine status of the population in Russia and the world: what do we have for 2019? Klinicheskaja i jeksperimental'naja tireoidologija 2019; 15 (2): 73–82 (in Russian).][Sharapova O.V., Dedov I.I., Korsunskiy A.A., Peterkova V.A., Ivanov S.A., Shcheplyagina L.A., Kasatkina E.P., Baleva L.S., Shilin D.E., Yakovleva I.N. Iodine Deficiency Disorders in Chil-dren in the Russian Federation. Voprosy sovremennoy pediatrii 2004; 3 (3): 8–14 (in Russian).][Gudkov А.B., Popova О.N., Lukmanova N.B. Ecological-physiological characteristic of northern climatic factors literature review. Ekologiya cheloveka 2012; 1: 12–17 (in Russian).][Gorbachev A.L. Structural and functional features of the human thyroid system and its trace element status in the North-East of Russia: avtoref. dis. ... doct. biol. nauk. Arkhangelsk 2002; 42 (in Russian).][Platonova N.M. Iodine deficiency: current status. Klinicheskaya i eksperimental'naya tireoidologiya 2015; 11 (1): 12–21 (in Russian).][UNICEF. IGN. Guidance on the monitoring of salt iodization programmes and determination of population iodine status: Russian language version. Klinicheskaya i eksperimental'naya tireoidologiya 2018; 14 (2): 100–112 (in Russian).]