Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector728310.17816/pmj34563-68Research ArticleON AGE PECULIARITIES OF INFECTIOUS MONONUCLEOSISPermyakovaA Vderucheva@mail.ruLvovaI I-DeryushevaA Yu-15102017345636804122017Copyright © 2017, Permyakova A.V., Lvova I.I., Deryusheva A.Y.2017Aim. To determine the age peculiarities of infectious mononucleosis (IM), caused by Epstein-Barr virus, in hospitalized children. Materials and methods. On the basis of case histories of 50 children with infectious mononucleosis, caused by Epstein-Barr virus, who were hospitalized to children’s unit of Perm Regional Clinical Infectious Hospital in 2015, retrospective clinicostatistical analysis was carried out. Results. By means of mathematical prognostic modeling of age peculiarities of infectious mononucleosis, induced by Epstein-Barr virus, direct correlation dependence between children’ age and development of hepatitis with cytolysis syndrome was stated. To assess the probability of risk, a logistic classification model was developed. It was indicated that children over 3, despite moderately severe disease, are usually hospitalized reliably later, than younger children that can have unfavorable consequences due to late therapy of hepatitis. Conclusions. The created logistic classification model for assessment of age-dependent probability of risk for the development of hepatitis with cytolysis syndrome in Epstein-Barr infection indicated its growth by 1.5 times in children, reaching the age of 5.5 years.Infectious mononucleosisEpstein-Barr virusage peculiaritieshepatitischildrenИнфекционный мононуклеозвирус Эпштейна-Баррвозрастные особенностигепатитдети[Баранова И.П. Клинико-лабораторная характеристика гепатита при инфекционном мононуклеозе. Известия высших учебных заведений. Поволжский регион. Медицинские науки 2012; 22 (2): 26-32.][Львова И.И., Гирева Т.В., Батракова Г.В. Диагностика инфекционного мононуклеоза в детской инфекционной больнице. Материалы научной сессии 2007 года ГОУ ВПО ПГМА им. ак. Е.А. Вагнера Росздрава. Пермь 2007; 52-54.][Хмилевская С.А., Зайцева И.А., Михайлова Е.В. Изменение функционального состояния печени при Эпштейна-Барр-вирусном мононуклеозе у детей. Саратовский научно-медицинский журнал 2009; 4: 572-577.][Авива Петри. Наглядная медицинская статистика: пер. с англ. под ред. В.П. Леонова. М.: ГЭОТАР-Медиа 2009; 168.][Base Group Labs - профессиональный поставщик программных продуктов и решений в области анализа данных; available at: http: //www.basegroup.ru/company/about/.][Banko A., Lazarevic I., Stevanovic G. Analysis of the variability of epstein-barr virus genes in infectious mononucleosis: Investigation of the Potential Correlation with biochemical parameters of hepatic involvement. Journal of Medical Biochemistry 2016; 35 (3): 337-346. DOI:10.1515/jomb-2015-0021][Odumade O.A., Hogquist K.A., Balfour H.H. Progress and problems in understanding and managing primary Epstein-Barr virus infections. Clinical Microbiology Reviews 2011; 24 (1): 193-209. DOI:10.1128/CMR.00044-10][Wang Y., Li J., Ren Y., Zhao H. The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children. Clinical and molecular hepatology 2013; 19 (4): 382-388. DOI:10.3350/cmh.2013.19.4.382]