Perm Medical JournalPerm Medical Journal0136-14492687-1408Eco-Vector918310.17816/pmj35399-105Review ArticleMonocytic chemotactic protein-1 in physiology and medicine (review of literature)KolotovK. A.sgkb@medkirov.ruRasputinP. G.sgkb@medkirov.ruSouthern Clinical Emergency HospitalKirov State Medical University150720183539910501082018Copyright © 2018, Kolotov K.A., Rasputin P.G.2018<p>Monocytic chemotactic protein-1-cytokin, attributed to the group of chemokins, is the most powerful factor of monocyte chemotaxis in the body of mammalians as well as memory T-cells and dendrite cells to inflammatory foci and is produced upon tissue damages or infection introduced. MCP-1 is mainly secreted by monocytes, macrophages and dendrite cells. Clinical significance of MCP-1 consists in participation of some diseases in pathogenesis: psoriasis, rheumatoid arthritis, atherosclerosis. 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