Perm Medical JournalPerm Medical JournalПермский медицинский журнал (сетевое издание "Perm medical journal")0136-14492687-1408Eco-Vector9576110.17816/pmj38476-84Literature reviewОбзор литературыReview ArticleExosomes and myocardial infarction: scientific and practical interestЭкзосомы и инфаркт миокарда: научный и практический интересKhlynovaO. V.ХлыноваО. В.
Russian Federation

MD, PhD, Professor, Corresponding Member of the Russian Аcademy of Sciences, Head of Department of Hospital Therapy and Cardiology

доктор медицинских наук, профессор, член-корреспондент РАН, заведующая кафедрой госпитальной терапии и кардиологии

olgakhlynova@mail.ruRodionovR. A.РодионовР. А.
Russian Federation

postgraduate student of Department of Hospital Therapy and Cardiology

аспирант кафедры госпитальной терапии и кардиологии

olgakhlynova@mail.ruKarpuninaN. S.КарпунинаН. С.
Russian Federation

MD, PhD, Аssistant Professor, Professor of Department of Hospital Therapy and Cardiology

доктор медицинских наук, доцент, профессор кафедры госпитальной терапии и кардиологии

olgakhlynova@mail.ruShishkinaE. A.ШишкинаЕ. А.
Russian Federation

MD, PhD, Аssistant Professor of Department of Hospital Therapy and Cardiology

доктор медицинских наук, доцент кафедры госпитальной терапии и кардиологии

olgakhlynova@mail.ruE.A. Vagner Perm State Medical UniversityПермский государственный медицинский университет имени академика Е.А. Вагнера1508202138476840101202201012022Copyright ©; 2021, Khlynova O.V., Rodionov R.A., Karpunina N.S., Shishkina E.A.Copyright ©; 2021, Хлынова О.В., Родионов Р.А., Карпунина Н.С., Шишкина Е.А.2021Khlynova O.V., Rodionov R.A., Karpunina N.S., Shishkina E.A.Хлынова О.В., Родионов Р.А., Карпунина Н.С., Шишкина Е.А.http://creativecommons.org/licenses/by-sa/4.0https://permmedjournal.ru/PMJ/article/view/95761

A review of the literature on the biological role of exosomes in the pathophysiology of a number of pathological conditions, including damage to the heart muscle in the variant of myocardial infarction (MI), is presented. In the last decade, exosomes have begun to be actively studied; a lot of data have appeared on their nature and role in intercellular transport and signaling both in normal conditions and in pathology. Exosomes are important carriers of biological information, facilitating intercellular communication and participating in the pathophysiology of various cardiovascular diseases. In myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response, which is a vital process for cardiac damage, repair, and remodeling. A growing body of evidence suggests that exosomes are involved in the inflammatory response and immune regulation after MI.

Представлен обзор литературы о биологической роли экзосом в патофизиологии ряда патологических состояний, включая поражение сердечной мышцы в варианте инфаркта миокарда. В последнее десятилетие экзосомы стали активно изучаться, появилось множество данных об их природе и роли в межклеточном транспорте и сигналинге как в норме, так и при патологии. Экзосомы являются важными носителями биологической информации, облегчающими межклеточную коммуникацию и участвующими в патофизиологии различных сердечно-сосудистых заболеваний. При инфаркте миокарда массивная гибель кардиомиоцитов вызывает сильную воспалительную реакцию, которая является жизненно важным процессом повреждения, восстановления и ремоделирования сердца. Все больше данных свидетельствует о том, что экзосомы участвуют в воспалительной реакции и иммунной регуляции после инфаркта миокарда.

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