Testing of the Technological Scheme for the Isolation of Lutetium-177 from an Irradiated Ytterbium Target

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Abstract

The results of an experiment to verify a complex technology for isolating 177Lu from an irradiated 1-g ytterbium target are presented. The main components of the experimental installation, which is mounted in a research hot cell, are described. These include the extraction and separation of lutetium and ytterbium, the evaporation and concentration of 177Lu, and its chromatographic purification. The feasibility of obtaining a pharmaceutical substance “no-carrier-added lutetium-177 trichloride” that meets the standards set by the European Pharmacopoeia has been confirmed.

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About the authors

E. V. Ambul

Khlopin Radium Institute

Author for correspondence.
Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

N. D. Goletskiy

Khlopin Radium Institute; St. Petersburg State Institute of Technology (Technical University)

Email: goletsky@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022; Moskovskii pr. 26, St. Petersburg, 190013

A. A. Naumov

Khlopin Radium Institute; St. Petersburg State Institute of Technology (Technical University)

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022; Moskovskii pr. 26, St. Petersburg, 190013

E. A. Puzikov

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

M. V. Mamchich

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

E. O. Zagladkin

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

N. A. Dedov

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

N. A. Semenova

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

S. A. Rodionov

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

N. V. Kovalev

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

A. M. Prokoshin

Khlopin Radium Institute

Email: ambyllisa@khlopin.ru
Russian Federation, 2-I Murinskii pr. 28, St. Petersburg, 197022

I. A. Ushakov

National Research Tomsk Polytechnic University

Email: ambyllisa@khlopin.ru
Russian Federation, pr. Lenina 30, Tomsk, 634050

V. V. Zukau

National Research Tomsk Polytechnic University

Email: ambyllisa@khlopin.ru
Russian Federation, pr. Lenina 30, Tomsk, 634050

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Supplementary files

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2. Fig. 1. Principal technological scheme of the extraction separation of 177Lu.

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3. Fig. 2. Placement of the extraction unit.

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4. Fig. 3. Technological scheme of 177Lu extraction from irradiated ytterbium target. **The scheme presents a proposal for regeneration of ytterbium into a new target.

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5. Fig. 4. Dependence of the relative activity of 177Lu and 175Yb on time at the cascade exit (points - experiment, lines - model calculation [30]).

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6. Fig. 5. Chromatogram of 177Lu and 175 Yb separation on column 1 with LN2 RETEX.

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7. Fig. 6. Desorption of 177Lu from the Chromafix PS-H+ cartridge.

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8. Fig. 7. Variation of 177Lu specific activity over the time of irradiation of ytterbium target in the reactor, its exposure, isolation of 177Lu preparation and on the 7th day of 177Lu preparation calibration.

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