THE ENDOCRINE METABOLIC DISORDERS IN CHILDREN OF FEMALE WORKERS OF NUCLEAR ENERGETICS ENTERPRISE

The article presents the results of evaluation of post-natal deviations in offspring of individuals underwent irradiation exposure at work that testify necessity of supporting radiation security of personnel of reproductive age. Purpose of study. To analyze endocrine metabolic disorders in children of female workers of nuclear industry having cumulated pre-conceptive doses of external gamma-radiation. Material and methods. The retrospective analysis was carried out concerning data of medical documentation of 1190 children prior to age of 15 years old. Out of them, 238 children were offspring of mothers underwent radiation exposure at work. The methods of non-parametric statistics were applied. The factorial analysis method of principal components was applied to establish latent factors. Results. The range of pre-conceptive doses of external gamma-radiation of gonads of mothers made up to 0,09-3523,7 mGy and average absorbed dose on gonads made up to 373,6 ± 34,2 mGy. In the groups, no significant differences in rate of endocrine metabolic pathology were established. In the structure of class "Diseases of endocrine system, nutrition disorders and metabolic imbalance" prevalence of rickets and malnutrition of children of early age were established. In the group of offspring of radiation exposed mothers, a statistically reliable exceeding of both thyroid pathology in general and iodine-deficiency conditions was established with main input of sub-group of girls. There was no evidence of autoimmune endocrine pathology and malignant neoplasms of thyroid gland in the examined groups. The factorial analysis in the group of offspring of female workers of nuclear industry marked out five factors characterizing feeding of infant of the first year of life (dispersion 25.5%), obstetrical anamnesis of mothers (dispersion 11.1%), harmful habits of mothers (dispersion 9.8%), anthropometric status of newborns (dispersion 7.3%) and pre-conceptive irradiation of mothers (dispersion 6.2%). The higher factorial load of variable "dose on gonads" (0.8) is demonstrated. Conclusion. The presented characteristics can be used for early detection of endocrine metabolic disorders in offspring of irradiation exposed mothers in case of dispensary observation.

endocrine metabolic disorders, children of female workers of nuclear industry, post-natal deviations, radiation exposure, pre-conceptive doses of external gamma-radiation