Level of tryptophan signaling molecules in children with different dynamics of obesity development

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Abstract

The high incidence of obesity in children is an extremely pressing problem in the modern health care system of many countries. There is an increase in the incidence of obesity in children in Russia, which is dangerous not only due to the development of somatic concomitant pathologies, but also to a violation of the social adaptation of children. Without a doubt, the search for early biochemical indicators of stabilization and progress of obesity in older age is very important for the formation of a risk group and timely prevention of the development of obesity and its complications. Our study showed that when assessing the various dynamics of obesity development, it is necessary to take into account the gender of the child, which is ignored in many cases. A decrease in serum serotonin concentrations may be considered as an indicator associated with the stabilization or progression of obesity in girls. Whereas in boys prone to stabilization and/or progression of obesity, a reduced serum level of indole-3-acrylate may act as a predictor marker.

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About the authors

O. P. Shatova

Pirogov Russian National Research Medical University; Peoples’s Friendship University of Russia (RUDN University)

Author for correspondence.
Email: shatova.op@gmail.com
Russian Federation, Moscow; Moscow

I. M. Kolesnikova

Pirogov Russian National Research Medical University; National Medical Research Center for Endocrinology

Email: shatova.op@gmail.com
Russian Federation, Moscow; Moscow

E. M. Yagodkina

Pirogov Russian National Research Medical University

Email: shatova.op@gmail.com
Russian Federation, Moscow

S. S. Kaydoshko

Pirogov Russian National Research Medical University

Email: shatova.op@gmail.com
Russian Federation, Moscow

A. M. Gaponov

Research Center for Digital and Translational Biomedicine “Center for Molecular Health”

Email: shatova.op@gmail.com
Russian Federation, Moscow

S. A. Roumiantsev

Pirogov Russian National Research Medical University; National Medical Research Center for Endocrinology

Email: shatova.op@gmail.com
Russian Federation, Moscow; Moscow

A. V. Shestopalova

Pirogov Russian National Research Medical University; National Medical Research Center for Endocrinology

Email: shatova.op@gmail.com
Russian Federation, Moscow; Moscow

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2. Fig. 1. Indole, serotonin and kynurenine pathways of tryptophan metabolism [4, 8].

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