Regulation of Gene Expression by the MYC Transcription Factor Network during Exercise

I. V. Astratenkova; Астратенкова И. В.; N. D. Golberg; Гольберг Н. Д.; V. A. Rogozkin; Рогозкин В. А.

doi:10.31857/S0131164622601014

Regulation of Gene Expression by the MYC Transcription Factor Network during Exercise

Authors: Astratenkova I.V.¹, Golberg N.D.², Rogozkin V.A.²
Affiliations:
1. Saint-Petersburg State University
2. Saint-Petersburg Research Institute of Physical Culture
Issue: Vol 49, No 4 (2023)
Pages: 124-132
Section: ОБЗОРЫ
URL: https://permmedjournal.ru/0131-1646/article/view/664104
DOI: https://doi.org/10.31857/S0131164622601014
EDN: https://elibrary.ru/WYQMRR
ID: 664104

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Abstract
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Abstract

The results obtained in recent years on numerous functions of the MYC protein convincingly indicate that MYC overexpression induced by physical activity occurs at the transcriptional and epigenetic levels with the participation of low molecular weight metabolites formed during the enhancement of intermediate metabolism. The current hypothesis proposes that MYC network of transcription factors may account substantially for the exercise-induced adaptive changes in muscle and other vital organs through changes in lactate dynamics. This review presents the MYC transcription factor network that is involved in cell cycle regulation, growth, proliferation, and cell metabolism.

Keywords

MYC, metabolism, skeletal muscle, physical activity.

References

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