Enviar artigo por via de e-mail Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives
- Autores: Khachikyan R.D.1, Hovakimyan Z.G.1, Panosyan G.A.1, Mirzoyan L.S.1, Paronikyan R.G.1
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Afiliações:
- The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
- Edição: Volume 60, Nº 11 (2024)
- Páginas: 1159-1164
- Seção: Articles
- URL: https://permmedjournal.ru/0514-7492/article/view/682502
- DOI: https://doi.org/10.31857/S0514749224110103
- EDN: https://elibrary.ru/QHGOZX
- ID: 682502
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Resumo
It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.
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Sobre autores
R. Khachikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0006-2014-7861
Armênia, Azatutyan Ave. 26, Yerevan, 0014
Z. Hovakimyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0000-1604-5834
Armênia, Azatutyan Ave. 26, Yerevan, 0014
G. Panosyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0000-0001-8311-6276
Armênia, Azatutyan Ave. 26, Yerevan, 0014
L. Mirzoyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Autor responsável pela correspondência
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0003-4915-9805
Armênia, Azatutyan Ave. 26, Yerevan, 0014
R. Paronikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0000-0002-3845-6324
Armênia, Azatutyan Ave. 26, Yerevan, 0014
Bibliografia
- Nada A., Zayed M. F. and Gad W., Egypt. J. Chem., 1985, 28, 527–530. doi: 10.1002/chin.198801240
- Хачикян Р. Дж., Карамян Н. В., Паносян Г. А., Инджикян М. Г. Изв. РАН, Сер. хим. 2004, 8, 1982–1986. doi: 10.1007/s11172-006-0068-7
- Хачатрян Р.А., Хачикян Р.Дж., Карамян Н.В. Паносян Г. А., Инджикян М. Г. ХГС, 2004, 40 (4), 446–451. doi: 10.1023/B:COHC.0000033535.93962.f5
- Kadi M., X. El’, Hashash M.A. El’, Sayed M.A. Rev. Roum. Chem. 1981, 26 (8), 1161–1165.
- Asif M., Singh A., Khan S.A., Husain A. Braz. J. Pharm. Sci. 2018, 54, 1–12. doi: 10.1590/s2175-97902018000300040
- Geiger W.B., Conn J.E. J. Am. Chem. Soc. 1945, 67 (1), 112–116. doi: 10.1021/ja01217a038
- Cramer B.J., Schroeder W., Moran W.J., Nield C. H., Edwards M., Jarowski C. I., Puetzer B. J. Am. Pharm. Ass. Sci. Ed. 1948, 37, 439–449. doi: 10.1002/jps.3030371102
- Worrall R.L. Med. World 1946, 2.
- Bowden K., Dixon M.S., Ranson R.J. J. Chem. Res. 1979, 1, 8.
- Хачикян Р.Дж., Овакимян З.Г., Карамян Э.О., Пароникян Р. В., Степанян Г. М., Балян А. А. Хим. ж. Армении 2017, 70 (3), 384–388.
- Хачикян Р.Дж., Овакимян З.Г., Микаелян А.А., Пароникян Р. В., Степанян Г. М. Хим. фарм. ж. 2017, 51 (10), 85–88. doi: 10.30906/0023-1134-2017-51-10-22-25
- Машковский М.Д., Лекарственные средства, М.: Новая волна. 2021, 1216–1218.
- Dunham N.W., Miya T.S. J. Am. Pharm. Ass. Sci. 1957, 46 (3), 208–209. doi: 10.1002/jps.3030460322
- Беленький М. Элементы количественной оценки фармакологического эффекта. Л.: Изд. Мед. литературы, 1963. 152–155.
- Vogel H.G. and Vogel W.H. Psychjtropic and neurotropic activity In Drug Discovery and Evaluation Berlin–N.Y.: Springer. 2008, 569–874.
- File Behav S.E., Brain. Res. 2001, 125, 151–157. doi: 10.1016/S0166-4328(01)00292-3
- Stanford S.C. J. Psycopharmac. 2007, 21, 134–135.
- Prut L., Berzung C. Eur. J. Pharmacol. 2003, 463, 3–33. doi: 10.1016/S0014-2999(03)01272-X
- Pelow S., File S.E. Pharmacol. Biochem. Behav. 1986, 24 (3), 525–529. doi: 10.1016/0091-3057(86)90552-6
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