Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН: научные результаты и перспективы исследований

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В 2024 г. Российской академии наук исполняется 300 лет, а Тихоокеанский институт биоорганической химии им. Г. Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) отпразднует свое 60-летие. ТИБОХ ДВО РАН является институтом с мировой репутацией в области биоорганической химии, а именно, структурно-химической биологии первичных и вторичных метаболитов из морских и наземных организмов, молекулярной биологии, в том числе изучения функций и биологических активностей и механизмов действия исследуемых природных соединений, молекулярно-генетических исследований. В статье представлены основные результаты работ ведущих лабораторий института по этим перспективным научным направлениям преимущественно за последние пять лет научных исследований.

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Павел Сергеевич Дмитренок

Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН

Email: paveldmt@piboc.dvo.ru
ORCID iD: 0000-0002-4416-7844

доктор химических наук, директор

Россия, Владивосток

Ксения Леонидовна Борисова

Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН

Автор, ответственный за переписку.
Email: science@piboc.dvo.ru
ORCID iD: 0000-0002-6572-8575

кандидат химических наук, ученый секретарь

Россия, Владивосток

Список литературы

  1. Guzii A. G., Makarieva T. N., Denisenko V. A., Gerasimenko A. V., Udovenko A. A., Popov R. S., Dmitrenok P. S., Golotin V. A., Fedorov S. N., Grebnev B. B., Stonik V. A. Guitarrins A–E and aluminumguitarrin A: 5-azaindoles from the Northwestern Pacific marine sponge Guitarra fimbriata // Journal of Natural Products. 2019. Vol. 82, N6. P. 1704–1709. https://doi.org/10.1021/acs.jnatprod.9b00334.
  2. Kolesnikova S. A., Lyakhova E. G., Kalinovsky A. I., Berdyshev D. V., Pislyagin E. A., Popov R. S., Grebnev B. B., Makarieva T. N., Minh C. V., Stonik V. A. Cyclobutastellettolides A and B, C19 norterpenoids from a Stelletta sp. marine sponge // Journal of Natural Products. 2019. Vol. 82, N11. P. 3196–3200. doi: 10.1021/acs.jnatprod.9b00824.
  3. Makarieva T. N., Ivanchina N. V., Dmitrenok P. S., Guzii A. G., Stonik V. A., Dalisay D. S., Molinski T. F. Oceanalin B, a hybrid α, ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside from the marine sponge Oceanapia sp. // Marine Drugs. 2021. Vol. 19, N11. Art. 635. https://doi.org/10.3390/md19110635.
  4. Makarieva T. N., Romanenko L. A., Mineev K. S., Shubina L. K., Guglya E. B., Kalinovskaya N. I., Ivanchina N. V., Guzii A. G., Belozerova O. A., Kovalchuk S. I., Popov R. S., Denisenko V. A., Mikhailov V. V., Babenko V. V., Ilina E. N., Malakhova M. V., Terekhov S. S., Kudzhaev A. M., Dmitrenok P. S., Yampolsky I. V., Stonik V. A. Streptocinnamides A and B, depsipeptides from Streptomyces sp. KMM 9044 // Organic Letters. 2022. Vol. 24, N27. P. 4892–4895. https://doi.org/10.1021/acs.orglett.2c01714.
  5. Mishchenko N. P., Krylova N. V., Iunikhina O. V., Vasileva E. A., Likhatskaya G. N., Pislyagin E. A., Tarbeeva D. V., Dmitrenok P. S., Fedoreyev S. A. Antiviral potential of sea urchin aminated spinochromes against Herpes simplex virus type 1 // Marine Drugs. 2020. Vol. 18, N11. Art. 550. https://doi.org/10.3390/md18110550.
  6. Tarbeeva D. V., Pislyagin E. A., Menchinskaya E. S., Berdyshev D. V., Kalinovskiy A. I., Grigorchuk V. P., Mishchenko N. P., Aminin D. L., Fedoreyev S. A. Polyphenolic compounds from Lespedeza bicolor protect neuronal cells from oxidative stress // Antioxidants. 2022. Vol. 11, N4. Art. 709. https://doi.org/10.3390/antiox11040709.
  7. Vasileva E. A., Mishchenko N. P., Tran V. T.T., Vo H. M.N., Fedoreyev S. A. Spinochrome identification and quantification in Pacific sea urchin shells, coelomic fluid and eggs using HPLC-DAD-MS // Marine Drugs. 2021. Vol. 19, N1. Art. 21. https://doi.org/10.3390/md19010021.
  8. Girich E. V., Rasin A. B., Popov R. S., Yurchenko E. A., Chingizova E. A., Trinh P. T.H., Ngoc N. T.D., Pivkin M. V., Zhuravleva O. I., Yurchenko A. N. New tripeptide derivatives asperripeptides A–C from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2 // Marine Drugs. 2022. Vol. 20, N1. Art. 77. https://doi.org/10.3390/md20010077.
  9. Zhuravleva O. I., Oleinikova G. K., Antonov A. S., Kirichuk N. N., Pelageev D. N., Rasin A. B., Menshov A. S., Popov R. S., Kim N. Yu., Chingizova E. A., Chingizov A. R., Volchkova O. O., von Amsberg G., Dyshlovoy S. A., Yurchenko E. A., Guzhova I. V., Yurchenko A. N. New antibacterial chloro-containing polyketides from the alga-derived fungus Asteromyces cruciatus KMM 4696 // Journal of Fungi. 2022. Vol. 8, N5. Art. 454. https://doi.org/10.3390/jof8050454.
  10. Smetanina O. F., Yurchenko A. N., Ivanets E. V., Trinh P. T.H., Antonov A. S., Dyshlovoy S. A., von Amsberg G., Kim N. Yu., Chingizova E. A., Pislyagin E. A., Menchinskaya E. S., Yurchenko E. A., Van T. T.T., Afiyatullov S. S. Biologically active echinulin-related indolediketopiperazines from the marine sediment-derived fungus Aspergillus niveoglaucus // Molecules. 2020. Vol. 25, N1. Art. 61. https://doi.org/10.3390/molecules25010061.
  11. Leshchenko E. V., Antonov A. S., Dyshlovoy S. A., Berdyshev D. V., Hauschild J., Zhuravleva O. I., Borkunov G. V., Menshov A. S., Kirichuk N. N., Popov R. S., Gerasimenko A. V., Udovenko A. A., Graefen M., Bokemeyer C., von Amsberg G., Yurchenko A. N. Meroantarctines A–C, meroterpenoids with rearranged skeletons from the alga-derived fungus Penicillium antarcticum KMM 4685 with potent p-glycoprotein inhibitory activity // Journal of Natural Products. 2022. Vol. 85, N12. P. 2746–2752. https://doi.org/10.1021/acs.jnatprod.2c00677.
  12. Kokoulin M. S., Kuzmich A. S., Romanenko L. A., Chikalovets I. V. Sulfated capsular polysaccharide from the marine bacterium Kangiella japonica inhibits T-47D cells growth in vitro // Carbohydrate Polymers. 2022. Vol. 290. Art. 119477. https://doi.org/10.1016/j.carbpol.2022.119477.
  13. Kokoulin M. S., Sigida E. N., Kuzmich A. S., Ibrahim I. M., Fedonenko Yu.P., Konnova S. A. Structure and antiproliferative activity of the polysaccharide from Halomonas aquamarina related to Cobetia pacifica // Carbohydrate Polymers. 2022. Vol. 298. Art. 120125. https://doi.org/10.1016/j.carbpol.2022.120125.
  14. Yermak I. M., Gorbach V. I., Glazunov V. P., Kravchenko A. O., Mishchenko N. P., Pimenova E. A., Davydova V. N. Liposomal form of the echinochrome-carrageenan complex // Marine Drugs. 2018. Vol. 16, N9. Art. 324. https://doi.org/10.3390/md16090324.
  15. Sergeev A. A., Naberezhnykh G. A., Khomenko V. A., Amosov A. V., Nepomnyaschiy A. V., Solov’eva T.F., Chistyulin D. K., Tutov M. V., Kulchin Yu.N., Novikova O. D. In situ-synthesized cadmium sulfide quantum dots in pore-forming protein and polysaccharide matrices for optical biosensing applications // Colloids and Surfaces B: Biointerfaces. 2022. Vol. 217. Art. 112607. https://doi.org/10.1016/j.colsurfb.2022.112607.
  16. Sintsova O., Gladkikh I., Kalinovskii A., Zelepuga E., Monastyrnaya M., Kim N., Shevchenko L., Peigneur S., Tytgat J., Kozlovskaya E., Leychenko E. Magnificamide, a β-defensin-like peptide from the mucus of the sea anemone Heteractis magnifica, is a strong inhibitor of mammalian α-amylases // Marine Drugs. 2019. Vol. 17, N10. Art. 542. https://doi.org/10.3390/md17100542.
  17. Kalina R. S., Koshelev S. G., Zelepuga E. A., Kim N. Yu., Kozlov S. A., Kozlovskaya E. P., Monastyrnaya M. M., Gladkikh I. N. APETx-like peptides from the sea anemone Heteractis crispa, diverse in their effect on ASIC1a and ASIC3 ion channels // Toxins. 2020. Vol. 12, N4. Art. 266. https://doi.org/10.3390/toxins12040266.
  18. Kalina R. S., Peigneur S., Zelepuga E. A., Dmitrenok P. S., Kvetkina A. N., Kim N. Y., Leychenko E. V., Tytgat J., Kozlovskaya E. P., Monastyrnaya M. M., Gladkikh I. N. New insights into the type II toxins from the sea anemone Heteractis crispa // Toxins. 2020. Vol. 12, N1. Art. 44. https://doi.org/10.3390/toxins12010044.
  19. Zelepuga E. A., Silchenko A. S., Avilov S. A., Kalinin V. I. Structure-activity relationships of holothuroid’s triterpene glycosides and some in silico insights obtained by molecular dynamics study on the mechanisms of their membranolytic action // Marine Drugs. 2021. Vol. 19, N11. Art. 604. https://doi.org/10.3390/md19110604.
  20. Silchenko A. S., Rasin A. B., Zueva A. O., Kusaykin M. I., Zvyagintseva T. N., Rubtsov N. K., Ermakova S. P. Discovery of a fucoidan endo-4O-sulfatase: Regioselective 4O-desulfation of fucoidans and its effect on anticancer activity in vitro // Carbohydrate Polymers. 2021. Vol. 271. Art. 118449. https://doi.org/10.1016/j.carbpol.2021.118449.
  21. Zueva A. O., Silchenko A. S., Rasin A. B., Malyarenko O. S., Kusaykin M. I., Kalinovsky A. I., Ermakova S. P. Production of high- and low-molecular weight fucoidan fragments with defined sulfation patterns and heightened in vitro anticancer activity against TNBC cells using novel endo-fucanases of the GH107 family // Carbohydrate Polymers. 2023. Vol. 318. Art. 121128. https://doi.org/10.1016/j.carbpol.2023.121128.
  22. Malyarenko O. S., Usoltseva R. V., Silchenko A. S., Ermakova S. P. Aminated laminaran from brown alga Saccharina cichorioides: synthesis, structure, anticancer, and radiosensitizing potential in vitro // Carbohydrate Polymers. 2020. Vol. 250. Art. 117007. https://doi.org/10.1016/j.carbpol.2020.117007.
  23. Chernysheva N., Bystritskaya E., Likhatskaya G., Nedashkovskaya O., Isaeva M. Genome-wide analysis of PL7 alginate lyases in the genus Zobellia // Molecules. 2021. Vol. 26, N8. Art. 2387. https://doi.org/10.3390/molecules26082387.
  24. Balabanova L., Shkryl Yu., Slepchenko L., Cheraneva D., Podvolotskaya A., Bakunina I., Nedashkovskaya O., Son O., Tekutyeva L. Genomic features of a food-derived Pseudomonas aeruginosa strain PAEM and biofilm-associated gene expression under a marine bacterial α-galactosidase // International Journal of Molecular Sciences. 2020. Vol. 21, N20. Art. 7666. https://doi.org/10.3390/ijms21207666.
  25. Dyshlovoy S. A., Pelageev D. N., Hauschild J., Borisova K. L., Kaune M., Krisp C., Venz S., Sabutskii Yu.E., Khmelevskaya E. A., Busenbender T., Denisenko V. A., Pokhilo N. D., Atopkina L. N., Graefen M., Schluter H., Stonik V. A., Bokemeyer C., Anufriev V. Ph., von Amsberg G. Successful targeting of the Warburg effect in prostate cancer by glucose-conjugated 1,4-naphthoquinones // Cancers. 2019. Vol. 11, N11. Art. 1690. https://doi.org/10.3390/cancers11111690.
  26. Dyshlovoy S. A., Pelageev D. N., Jakob L. S., Borisova K. L., Hauschild J., Busenbender T., Kaune M., Khmelevskaya E. A., Graefen M., Bokemeyer C., Anufriev V. Ph., von Amsberg G. Activity of new synthetic (2-chloroethylthio)-1,4-naphthoquinones in prostate cancer cells // Pharmaceuticals. 2021. Vol. 14, N10. Art. 949. https://doi.org/10.3390/ph14100949.
  27. Menchinskaya E., Chingizova E., Pislyagin E., Likhatskaya G., Sabutski Yu., Pelageev D., Polonik S., Aminin D. Neuroprotective effect of 1,4-naphthoquinones in an in vitro model of paraquat and 6-OHDA-induced neurotoxicity // International Journal of Molecular Sciences. 2021. Vol. 22, N18. Art. 9933. https://doi.org/10.3390/ijms22189933.
  28. Menchinskaya E., Gorpenchenko T., Silchenko A., Avilov S., Aminin D. Modulation of doxorubicin intracellular accumulation and anticancer activity by triterpene glycoside cucumarioside A2–2 // Marine Drugs. 2019. Vol. 17, N11. Art. 597. https://doi.org/10.3390/md17110597.
  29. Nedashkovkaya O. I., Kim S.-G., Balabanova L. A., Zhukova N. V., Son O. M., Tekutyeva L. A., Mikhailov V. V. Genome-based classication of strain 16-SW-7, a marine bacterium capable of converting B red blood cells, as Pseudoalteromonas distincta and proposal to reclassify Pseudoalteromonas paragorgicola as a later heterotypic synonym of Pseudoalteromonas distincta // Frontiers in Microbiology. 2021. Vol. 12. Art. 809431. https://doi.org/10.3389/fmicb.2021.809431.
  30. Romanenko L., Otstavnykh N., Tanaka N., Kurilenko V., Svetashev V., Tekutyeva L., Mikhailov V., Isaeva M. Characterization and genomic analysis of Fererhizobium litorale gen. nov., sp. nov., isolated from the sandy sediments of the Sea of Japan seashore // Microorganisms. 2023. Vol. 11, N10. Art. 2385. https://doi.org/10.3390/microorganisms11102385.
  31. Мягчилов А. В., Соколова Л. И., Горовой П. Г., Кечайкин А. А. Особенности состава флавоноидов в серпухе венценосной (Serratula coronata L.S.L.) Сибири и Дальнего Востока России // Химия растительного сырья. 2020. № 2. С. 171–179. https://doi.org/10.14258/jcprm.2020026663.
  32. Sintsova O., Popkova D., Kalinovskii A., Rasin A., Borozdina N., Shaykhutdinova E., Klimovich A., Menshov A., Kim N., Anastyuk S., Kusaykin M., Dyachenko I., Gladkikh I., Leychenko E. Control of postprandial hyperglycemia by oral administration of the sea anemone mucus-derived α-amylase inhibitor (magnificamide) // Biomedicine and Pharmacotherapy. 2023. Vol. 168. Art. 115743. https://doi.org/10.1016/j.biopha.2023.115743.
  33. Kalina R. S., Kasheverov I. E., Koshelev S. G., Sintsova O. V., Peigneur S., Pinheiro-Junior E.L., Popov R. S., Chausova V. E., Monastyrnaya M. M., Dmitrenok P. S., Isaeva M. P., Tytgat J., Kozlov S. A., Kozlovskaya E. P., Leychenko E. V., Gladkikh I. N. Nicotinic acetylcholine receptors are novel targets of APETx-like toxins from the sea anemone Heteractis magnifica // Toxins. 2022. Vol. 14, N10. Art. 697. https://doi.org/10.3390/toxins14100697.
  34. Kozlovskaya E. P., Popov A. M., Styshova O. N., Vakhrushev A. I., Rutckova T. A., Podvolotskaya A. B., Tekutyeva L. A. Comparative study of the pharmacological properties of luteolin and its 7,3′-disulfate // Marine Drugs. 2022. Vol. 20, N7. Art. 426. https://doi.org/10.3390/md20070426.

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