Investigations of technology for processing marine aquatic organisms

Cover Page

Cite item

Full Text

Abstract

Information about the most important research of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry biotechnology laboratory for the past ten years is given. Methods for obtaining and using biologically active substances of marine hydrobionts of plant and animal origin are described.

Full Text

Restricted Access

About the authors

Elena V. Kupera

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Author for correspondence.
Email: elena.kupera@mail.ru
ORCID iD: 0009-0003-6818-669X

Researcher

Russian Federation, Vladivostok

Tatyana A. Rutskova

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: tanya1119@yandex.ru
ORCID iD: 0009-0009-4084-6944

Researcher

Russian Federation, Vladivostok

Alexey I. Vakhrushev

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: aivahr@mail.ru
ORCID iD: 0009-0004-8662-1656

Junior Researcher

Russian Federation, Vladivostok

Vyacheslav V. Makhankov

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: mvvslav@mail.ru
ORCID iD: 0000-0001-7885-0556

Candidate of Sciences in Chemistry, Researcher

Russian Federation, Vladivostok

Alexander M. Popov

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: popovam@piboc.dvo.ru
ORCID iD: 0000-0002-7857-9214

Doctor of Sciences in Biology, Leading Researcher, Professor

Russian Federation, Vladivostok

Emma P. Kozlovskaya

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: kozempa@mail.ru
ORCID iD: 0000-0002-8110-0382

Doctor of Sciences in Chemistry, Leading Researcher, Professor

Russian Federation, Vladivostok

References

  1. Artyukov A.A., Rutskova T.A., Kupera E.V., Makhan’kov V.V., El’kin Yu.N., Kozlovskaya Eh.P. Sposob polucheniya kal’tsiisoderzhashchei kompozitsii iz pantsirya morskikh ezhei: pat. RF № 2611847; 01.03.2017; Byul. № 7. (In Russ.).
  2. Elyakov G.B., Maksimov O.B., Fedoreev S.A., Kol’tsova E.A., Mishchenko N.P., Glebko L.I., Krasovskaya N.P., Artyukov A.A. Lekarstvennyi preparat Gistokhrom dlya lecheniya ostrogo infarkta miokarda i ishemicheskoi bolezni serdtsa: pat. RF № 2137472; 20.09.1999, Byul. № 26. (In Russ.).
  3. Elyakov G.B., Maksimov O.B., Fedoreev S.A., Kol’tsova E.A., Mishchenko N.P., Glebko L.I., Krasovskaya N.P., Artyukov A.A. Preparat Gistokhrom dlya lecheniya vospalitel’nykh zabolevanii setchatki i rogovitsy glaz: pat. RF № 2134107; 10.08.1999, Byul. № 22. (In Russ.).
  4. Artyukov A.A., Kupera E.V., Rutskova T.A., Kochergina T.Yu., Makhan’kov V.V., Kozlovskaya Eh.P. Sposob polucheniya vodorastvorimoi solevoi formy ehkhinokhroma A, prigodnoi dlya ispol’zovaniya v farmakologicheskoi i pishchevoi promyshlennosti: pat. RF № 2697197; 13.08.2019, Byul. № 23. (In Russ.).
  5. Kupera E.V., Artyukov A.A., Rutskova T.A., Kochergina T.Yu., Makhan’kov V.V., Kozlovskaya Eh.P. Sposob polucheniya 2,3,7-Trioksiyuglona (Spinokhroma V): pat. RF № 2568604; 20.11.2015, Byul. 32. (In Russ.).
  6. Pozharitskaya O.N., Shikov A.N., Makarova M.N., Ivanova S.A., Kosman V.M., Makarov V.G., Bazgier V., Berka K., Otyepka M., Ulrichová J. Antiallergic effects of pigments isolated from green sea urchin (Strongylocentrotus droebachiensis) shells. Planta Med. 2013;79(18):1698–1704. doi: 10.1055/s-0033-1351098 10.1055/s-0033-1.
  7. Gromova O.A., Torshin I.Yu., Gogoleva I.V., Grishina T.R., Kerimkulova N.V. Organicheskie soli kal’tsiya: perspektivy ispol’zovaniya v klinicheskoi praktike. Russkii Meditsinskii Zhurnal. 2012;(28):1407–1411. (In Russ.).
  8. Astashkin S.N. Biologicheski aktivnaya dobavka k pishche dlya profilaktiki zabolevanii osteoporozom: pat. RF № 2527042; 27.08.2014, Byul. № 24. (In Russ.).
  9. Pozharitskaya O.N., Shikov A.N., Makarova M.N., Makarov V.G., Fomichev Yu.S. Kompleks biologicheski aktivnykh veshchestv dlya lecheniya i profilaktiki zabolevanii serdechno-sosudistoi sistemy: pat. RF № 2520695; 27.06.2014, Byul. № 18. (In Russ.).
  10. Artyukov A.A., Rutskova T.A., Kupera E.V., Makhan’kov V.V., Glazunov V.P., Kozlovskaya Eh.P. Sposob polucheniya karotinoidnogo kompleksa iz morskikh zvezd: pat. RF № 2469732; 20.12.2012, Byul. № 35. (In Russ.).
  11. Artyukov A.A., Kofanova N.N., Rutskova T.A., Kupera E.V., Kochergina T.Yu., Makhan’kov V.V., Glazunov V.P., Kozlovskaya Eh.P. Biologicheski aktivnye peptidy kollagena morskoi zvezdy i sposob ikh polucheniya: pat. RF № 2012135262; 20.02.2014, Byul. № 5. (In Russ.).
  12. Artyukov A.A., Kochergina T.Yu., Kupera E.V., Rutskova T.A., Zadorozhnyi P.A., El’kin Yu.N., Makhan’kov V.V., Kozlovskaya Eh.P. Sposob polucheniya voska i sterinov iz morskoi zvezdy Patiria pectinifera: pat. RF № 2601311; 10.11.2016, Byul. № 31. (In Russ.).
  13. Artyukov A.A., Vakhrushev A.I., Kupera E.V., Rutskova T.A., Kozlovskaya Eh.P. Sposob polucheniya karotinoidnogo kompleksa iz morskikh zvezd: pat. RF № 2761524; 09.12.2021, Byul. № 34. (In Russ.).
  14. Breithaupt D.E. Identification and quantification of astaxanthin esters in shrimp (Pandalus borealis) and in a microalga (Haematococcus pluvialis) by liquid chromatography−mass spectrometry using negative ion atmospheric pressure chemical ionization. J. Agric. Food. Chem. 2004;52(12):3870–3875. doi: 10.1021/jf049780b.
  15. Yuan J.-P., Peng J., Yin K., Wang J.-H. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Mol. Nutr. Food. Res. 2010;55(1):150–165. doi: 10.1002/mnfr.201000414.
  16. Miki W. Biological functions and activities of animal carotenoids. Pure and Applied Chemistry. 1991;63(1):141–146. doi: 10.1351/pac199163010141.
  17. Kidd Р. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altera. Med. Rev. 2011;16(4):355–364.
  18. Talukdar J., Dasgupta1 S., Nagle V., Bhadra B. COVID-19: Potential of microalgae derived natural astaxanthin as adjunctive supplement in alleviating cytokine storm. SSRN. 2020. doi: 10.2139/ssrn.3579738.
  19. Zaseev A.T., Samorodova I.M., Chaika E.S. Sposob polucheniya lechebnoi mazi dlya zhivotnykh: pat. RF № 2480199; 27.04.2013, Byul. № 12. (In Russ.).
  20. Fosterkh B.M., Yangt Kh., Kosgrouv T., Khasan Eh.A. Lechebnaya zhevatel’naya rezinka: pat. RF № 2476076; 27.02.2013, Byul. № 6. (In Russ.).
  21. Shmits G.G., Shevo K.A., Dombroski Eh., Dzherom R. Kompozitsii i sposoby uluchsheniya sostoyaniya sosudistoi sistemy: pat. RF № 2303373; 27.07.2007, Byul. № 21. (In Russ.).
  22. Egorova E.Yu., Roshchina N.N., Bakhtin G.Yu., Bakhtin Yu.V. Kompozitsiya dlya prigotovleniya biologicheski aktivnoi dobavki k pishche: pat. RF № 2426452; 20.08.2011, Byul. № 23. (In Russ.).
  23. Tsukamoto Y., Ikeda S., Uwai K., Taguchi R., Chayama K., Sakaguchi T., Narita R., Yao W.-L., Takeuchi F., Otakaki Y., Watashi K., Wakita T., Kato H., Fujita T. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLOS ONE. 2018;13(5). e0197664. doi: 10.1371/journal.pone.0197664.
  24. Krylova N.V., Leonova G.N., Maystrovskaya O.S., Popov A.M., Artyukov A.A. Mechanisms of antiviral activity of the polyphenol complex from seagrass of the Zosteraceae family against tick-borne encephalitis virus. Bul. оf Exp. Biology and Med. 2018;165(1):61–63.
  25. Hariono M., Abdullah N., Damodaran K.V., Kamarulzaman E.E., Mohamed N., Hassan S.S., Shamsuddin S., Wahab H.A. Potential new H1N1 neuraminidase inhibitors from ferulic acid and vanillin: molecular modelling, synthesis and in vitro assay. Scientific Reports. 2016;6(1):38692. doi: 10.1038/srep38692.
  26. Paraiso I.L., Revel J.S., Stevens J.F. Potential use of polyphenols in the battle against COVID-19. Current Opinionin Food Science. 2020;32:149–155. doi: 10.1016/j.cofs.2020.08.004.
  27. Enerstvedt K.H., Jordheim M., Andersen O.M. Isolation and identification of flavonoids found in Zostera marina collected in norwegian coastal waters. American Journal of Plant Sciences. 2016;7:1163–1172. doi: 10.4236/ajps.2016.77111.
  28. Quackenbush R.C., Bunn D., Lingren W. HPLC determination of phenolic acids in the water-soluble extract of Zostera marina L. (Eelgrass). Aquatic Botany. 1986;24(1):83–89. doi: 10.1016/0304-3770(86)90119-1.
  29. Artyukov A.A., Kupera E.V., Rutskova T.A., Makhan’kov V.V., Novikov V.L., Glazunov V.P., Popov A.M., Kozlovskii A.S., Kozlovskaya Eh.P. Sposob polucheniya rozmarinovoi kisloty: pat. RF № 2401827; 20.10.2010, Byul. № 29. (In Russ.).
  30. Artyukov A.A., Kochergina T.Yu., Rutskova T.A., Kupera E.V., Novikov V.L., Glazunov V.P., Makhan’kov V.V., Kozlovskaya Eh.P. Sposob polucheniya 7,3’-disul’fata lyuteolina: pat. RF № 2432960; 10.11.2011, Byul. № 31. (In Russ.).
  31. Popov A.M., Artyukov A.A., Krivoshapko O.N., Krylova N.V., Leonova G.N., Kozlovskaya Eh.P. Sredstvo, obladayushchee antioksidantnym, kardioprotektornym, protivodiabeticheskim, protivovospalitel’nym i protivovirusnym deistviem: pat. RF № 2432959; 10.11.2011, Byul. № 31. (In Russ.).
  32. Ou S., Kwok K.-C. Ferulic acid: pharmaceutical functions, preparation and applications in foods. J. Sci. Food Agric. 2004;84:1261–1269. doi: 10.1002/jsfa.1873.
  33. Vakhrushev A.I., Kupera E.V., Rutskova T.A., Makhan’kov V.V., Podvolotskaya A.B., Tekut’eva L.A., Kozlovskaya Eh.P. Sposob kompleksnoi pererabotki morskoi travy semeistva Zosteraceae: pat. RF № 2796368; 22.05.2023, Byul. № 15. (In Russ.).
  34. Fruentov N.K. et al. Obshchie voprosy adaptatsii. Vladivostok: DVNTS AN SSSR; 1976. S. 63–68. (In Russ.).
  35. Artyukov A.A., Kupera E.V., Rutskova T.A., Makhan’kov V.V., Glazunov V.P., Krasovskaya N.P., Kozlovskaya Eh.P. Kompozitsiya ingredientov dlya funktsional’nykh pishchevykh produktov: pat. RF № 2644957; 15.02.2018, Byul. № 5. (In Russ.).
  36. Artyukov A.A., Kupera E.V., Rutskova T.A., Makhan’kov V.V., Glazunov V.P., Klimovich A.A., Kozlovskaya Eh.P. Sredstvo na osnove biologicheski aktivnykh soedinenii morskikh gidrobiontov, obladayushchee kantserpreventivnym deistviem i povyshayushchee terapevticheskuyu aktivnost’ protivoopukholevykh preparatov: pat. RF № 2659682; 03.07.2018, Byul. № 19. (In Russ.).

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. A. HPLC of the carotenoid complex of the starfish P. pectinifera (X-axis - retention time, min; Y - absorption intensity at 450 nm): 1 - 7,8,7',8'-tetradehydroastaxanthin; 2 - 7,8-didehydroastaxanthin; 3 - astaxanthin; 4 - astaxanthin, pectenolone, 4-hydroxyalloxanthin, 4-ketoalloxanthin; 5 - 4-hydroxyalloxanthin, pectenolone, 4-ketoalloxanthin; 6 - 7,8,7',8'-tetradehydroastaxanthin; 7 - 7,8-didehydroastaxanthin, 7,8,7',8'-detradehydroastaxanthin; 8 - astaxanthin, unidentified carotenoids. B. MS spectrum of the carotenoid peak with retention time 7.266 min

Download (219KB)
3. Fig. 2. HPLC chromatogram of a product based on BAS of marine hydrobionts containing: echinochrome (1), fucoxanthin (2), astaxanthin (3), zeaxanthin (4) and lutein (5). X axis - retention time of the substance, min; Y - absorption intensity (A) at 475 nm

Download (76KB)

Copyright (c) 2025 Russian Academy of Sciences