IMMUNOMODULATING EFFECT OF AMINOPHTHALHYDRAZIDE ON LIVER CELLS WITH DIFFUSE TOXIC DAMAGE

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Abstract

A comprehensive assessment of the role of stromal cells in regenerative processes has been carried out on the model of diffuse toxic liver damage with carbon tetrachloride (CCl4) and its correction with aminophthalhydrazide. It has been found that the immunomodulating effect of aminophthalhydrazide is manifested in a decrease in leukocyte infiltration, there is a sharp decrease in the level of CD45+ to the values of intact animals on the 7th and 14th days of the experiment. The number of CD3+ lymphocytes, mast cells and the area occupied by collagen are also reduced. Since the introduction of aminophthalhydrazide reduces the number of CD45+, CD3+ lymphocytes, but the number of sinusoidal cells increases compared to group of animals treated only with CCl4, it can be assumed that the decrease in the toxic effect of CCl4 is associated with the change in the number and functional activity of sinusoidal cells, which is aimed at removing the inflammatory response and restoring hepatic tissue after toxic damage.

About the authors

Z. A. Shafigullina

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Science

Author for correspondence.
Email: zlata_pyankova@mail.ru

Shafigullina Zlata Aleksandrovna

620002, 620049, Ekaterinburg

Russian Federation

I. G. Danilova

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Science

Email: ig-danilova@yandex.ru

Danilova Irina Georgievna

620002, 620049,Ekaterinburg

Russian Federation

I. F. Gette

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Science

Email: i.goette@yandex.ru

Gette Irina Fedorovna

620002,620049, Ekaterinburg

Russian Federation

V. G. Sencov

Ural State Medical University, Ministry of Health of the Russian Federation

Email: sencov-tox@yandex.ru

Sencov Valentin Gennadievich

620014, Ekaterinburg


Russian Federation

M. T. Abidov

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics

Email: alina144@mail.ru

Abidov Musa Tazhudinovich

620002, Ekaterinburg

Russian Federation

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Copyright (c) 2019 Shafigullina Z.A., Danilova I.G., Gette I.F., Sencov V.G., Abidov M.T.


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