Мақаланы E-mail арқылы жіберу EFFECT OF SUBCHRONIC USE OF SODIUM NITRITE ON THE FUNCTIONAL PARAMETERS OF AN ISOLATED RAT HEART
- Авторлар: Laptev D.S.1, Petunov S.G.1, Nechaykina O.V.1, Bobkov D.V.1
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Мекемелер:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal medical and biological Agency
- Шығарылым: № 2 (2022)
- Бөлім: Main unit
- ##submission.datePublished##: 21.04.2023
- URL: https://permmedjournal.ru/0869-7922/article/view/641451
- DOI: https://doi.org/10.15690/vramn358
- ID: 641451
Дәйексөз келтіру
Толық мәтін
Аннотация
On a model of an isolated rat heart, the cardio toxic effect of sodium nitrite was revealed after subchronic intragastric administration for 28 days at doses of 0.03; 0.3; 3.0 mg/kg. The use of sodium nitrite leads to dilatation of the coronary vessels and myocardium, impairment of its electrical activity in the shortening of the QT interval, associated with an increased risk of ventricular fibrillation, and a tendency to an increase in the amplitude of the T wave, which indicates myocardial ischemia. In a load with a total ischemic test, it was found that the magnitude of the change in indicators characterizing the restoration of myocardial function under conditions of reperfusion is inversely proportional to the dose of sodium nitrite used. Thus, it was found that sodium nitrite has cardiotoxicity at a dose of 0.028 mg/kg, which is two times lower than the permissible daily intake for humans established by the WHO (0.06 mg/kg).
Негізгі сөздер
Авторлар туралы
Denis Laptev
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal medical and biological Agency
Email: lapden@mail.ru
ORCID iD: 0000-0002-3960-3058
Candidate of Biological Sciences, Head of the Laboratory of Extreme Physiology, SPIN: 2873-5071, AuthorID: 527873 Ресей
Sergei Petunov
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal medical and biological Agency
Email: sergey-petunov@mail.ru
ORCID iD: 0000-0001-6781-8315
Candidate of Medical Sciences, Head of the Scientific and Organizational Department, SPIN: 1016-5878, AuthorID: 199594 Ресей
Olga Nechaykina
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal medical and biological Agency
Хат алмасуға жауапты Автор.
Email: olga2278@mail.ru
ORCID iD: 0000-0001-7151-7240
Senior Researcher of the Laboratory of Extreme Physiology, SPIN: 8194-8790, AuthorID: 921901 Ресей
Dmitry Bobkov
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal medical and biological Agency
Email: bdv21@yandex.ru
ORCID iD: 0000-0002-1823-4361
Senior Researcher of the Laboratory of Extreme Physiology, SPIN: 2673-8240, AuthorID: 985255 Ресей
Әдебиет тізімі
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