Coenzyme Q10 for Enhancing Physical Activity and Extending the Human Life Cycle

  • Authors: Bjørklund G.1, Semenova Y.2, Gasmi A.3, Ruwan Indika N.4, Hrynovets I.5, Lysiuk R.6, Lenchyk L.7, Uryr T.8, Yeromina H.9, Peana M.10
  • Affiliations:
    1. , Council for Nutritional and Environmental Medicine (CONEM)
    2. Department of Surgery,, Nazarbayev University School of Medicine,
    3. , Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
    4. Department of Biochemistry, Faculty of Medical Sciences,, University of Sri Jayewardenepura
    5. Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University
    6. CONEM Ukraine Life Science Research Group,, Danylo Halytsky Lviv National Medical University,
    7. Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy
    8. CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy,
    9. Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists,, National University of Pharmacy
    10. Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari
  • Issue: Vol 31, No 14 (2024)
  • Pages: 1804-1817
  • Section: Anti-Infectives and Infectious Diseases
  • URL: https://permmedjournal.ru/0929-8673/article/view/644339
  • DOI: https://doi.org/10.2174/0929867330666230228103913
  • ID: 644339

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Full Text

Abstract

Background:Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10 deficiency.

Objectives:This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.

Results:Although supplementation with CoQ10 offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.

Conclusion:Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

About the authors

Geir Bjørklund

, Council for Nutritional and Environmental Medicine (CONEM)

Author for correspondence.
Email: info@benthamscience.net

Yuliya Semenova

Department of Surgery,, Nazarbayev University School of Medicine,

Email: info@benthamscience.net

Amin Gasmi

, Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée

Email: info@benthamscience.net

Neluwa-Liyanage Ruwan Indika

Department of Biochemistry, Faculty of Medical Sciences,, University of Sri Jayewardenepura

Email: info@benthamscience.net

Ihor Hrynovets

Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Roman Lysiuk

CONEM Ukraine Life Science Research Group,, Danylo Halytsky Lviv National Medical University,

Email: info@benthamscience.net

Larysa Lenchyk

Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy

Email: info@benthamscience.net

Taras Uryr

CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy,

Email: info@benthamscience.net

Hanna Yeromina

Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists,, National University of Pharmacy

Email: info@benthamscience.net

Massimiliano Peana

Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari

Email: info@benthamscience.net

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