Curcuminoids as Cell Signaling Pathway Modulators: A Potential Strategy for Cancer Prevention
- Авторлар: Noor A.1, Shafi S.1, Sehar N.2, Qadir I.1, Bilquees 1, Rashid S.3, Arafah A.4, Rasool S.5, Dar N.6, Masoodi M.1, Rehman M.4
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Мекемелер:
- Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
- Centre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard
- Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdul Aziz University
- Department of Clinical Pharmacy, College of Pharmacy, King Saud University
- Department of School Education, Govt. of Jammu & Kashmir
- Salk Institute, Cellular Neurobiology Laboratory (CNB-P)
- Шығарылым: Том 31, № 21 (2024)
- Беттер: 3093-3117
- Бөлім: Anti-Infectives and Infectious Diseases
- URL: https://permmedjournal.ru/0929-8673/article/view/644713
- DOI: https://doi.org/10.2174/0929867331666230809100335
- ID: 644713
Дәйексөз келтіру
Толық мәтін
Аннотация
Despite substantial advancements in curative modern medicine in the last few decades, cancer risk and casualty rates have continued to mount globally. The exact reason for cancer's onset and progression is still unknown. However, skeletal and functional abnormalities in the genetic code are assumed to be the primary cause of cancer. Many lines of evidence reported that some medicinal plants can be utilized to curb cancer cell proliferation with a safe, fruitful, and cost-efficient perspective. Curcuminoid, isolated from Curcuma longa, have gotten a lot of focus due to their anticancer potential as they reduce tumor progression, invasion, and dissemination. Further, they modulated signal transduction routes like MAPK, PI3K/Akt/mTOR, JAK/STAT, and Wnt/β-catenin, etc., and triggered apoptosis as well as actuated autophagy in malignant cells without altering the normal cells, thus preventing cancer progression. Besides, Curcuminoid also regulate the function and expression of anti-tumor and carcinogenic miRNAs. Clinical studies also reported the therapeutic effect of Curcuminoid against various cancer through decreasing specific biomarkers like TNF-α, Bcl-2, COX-2, PGE2, VEGF, IκKβ, and various cytokines like IL-12p70, IL-10, IL-2, IFN-γ levels and increasing in p53 and Bax levels. Thus, in the present review, we abridged the modulation of several signal transduction routes by Curcuminoids in various malignancies, and its modulatory role in the initiation of tumor-suppressive miRNAs and suppression of the oncogenic miRNAs are explored. Additionally, various pharmacokinetic approaches have been projected to address the Curcuminoids bioavailability like the use of piperine as an adjuvant; nanotechnology- based Curcuminoids preparations utilizing Curcuminoids analogues are also discussed.
Негізгі сөздер
Авторлар туралы
Aneeza Noor
Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
Email: info@benthamscience.net
Saimeena Shafi
Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
Email: info@benthamscience.net
Nouroz Sehar
Centre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard
Email: info@benthamscience.net
Insha Qadir
Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
Email: info@benthamscience.net
Bilquees
Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
Email: info@benthamscience.net
Summya Rashid
Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdul Aziz University
Email: info@benthamscience.net
Azher Arafah
Department of Clinical Pharmacy, College of Pharmacy, King Saud University
Email: info@benthamscience.net
Saiema Rasool
Department of School Education, Govt. of Jammu & Kashmir
Email: info@benthamscience.net
Nawab Dar
Salk Institute, Cellular Neurobiology Laboratory (CNB-P)
Email: info@benthamscience.net
Mubashir Masoodi
Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir
Email: info@benthamscience.net
Muneeb Rehman
Department of Clinical Pharmacy, College of Pharmacy, King Saud University
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
Әдебиет тізімі
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