Activating Protein-1 (AP-1): A Promising Target for the Treatment of Fibrotic Diseases
- Authors: Pi Z.1, Qiu X.2, Liu J.2, Shi Y.3, Zeng Z.3, Xiao R.2
-
Affiliations:
- Department of Dermatolog, The Second Xiangya Hospital of Central South University
- Department of Dermatology, The Second Xiangya Hospital of Central South University
- Department of Dermatology,, The Second Xiangya Hospital of Central South University
- Issue: Vol 31, No 7 (2024)
- Pages: 904-918
- Section: Anti-Infectives and Infectious Diseases
- URL: https://permmedjournal.ru/0929-8673/article/view/645187
- DOI: https://doi.org/10.2174/0929867330666230209100059
- ID: 645187
Cite item
Full Text
Abstract
The fibrosis of tissues and organs occurs via an aberrant tissue remodeling process characterized by an excessive deposition of extracellular matrix, which can lead to organ dysfunction, organ failure, and death. Because the pathogenesis of fibrosis remains unclear and elusive, there is currently no medication to reverse it; hence, this process deserves further study. Activating protein-1 (AP-1)-comprising Jun (c-Jun, JunB, JunD), Fos (c-fos, FosB, Fra1, and Fra2), and activating transcription factor-is a versatile dimeric transcription factor. Numerous studies have demonstrated that AP-1 plays a crucial role in advancing tissue and organ fibrosis via induction of the expression of fibrotic molecules and activating fibroblasts. This review focuses on the role of AP-1 in a range of fibrotic disorders as well as on the antifibrotic effects of AP-1 inhibitors. It also discusses the potential of AP-1 as a new therapeutic target in conditions involving tissue and organ fibrosis.
About the authors
Zixin Pi
Department of Dermatolog, The Second Xiangya Hospital of Central South University
Email: info@benthamscience.net
Xiangning Qiu
Department of Dermatology, The Second Xiangya Hospital of Central South University
Email: info@benthamscience.net
Jiani Liu
Department of Dermatology, The Second Xiangya Hospital of Central South University
Email: info@benthamscience.net
Yaqian Shi
Department of Dermatology,, The Second Xiangya Hospital of Central South University
Email: info@benthamscience.net
Zhuotong Zeng
Department of Dermatology,, The Second Xiangya Hospital of Central South University
Author for correspondence.
Email: info@benthamscience.net
Rong Xiao
Department of Dermatology, The Second Xiangya Hospital of Central South University
Author for correspondence.
Email: info@benthamscience.net
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