An Updated Review on the Significance of DNA and Protein Methyltransferases and De-methylases in Human Diseases: From Molecular Mechanism to Novel Therapeutic Approaches
- Authors: Ghanbari M.1, Khosroshahi N.2, Alamdar M.3, Abdi A.4, Aghazadeh A.4, Feizi M.4, Haghi M.1
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Affiliations:
- Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
- Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University
- Department of Genetics Sciences, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University
- Department of Animal Biology, Faculty of Natural Sciences,, University of Tabriz
- Issue: Vol 31, No 23 (2024)
- Pages: 3550-3587
- Section: Anti-Infectives and Infectious Diseases
- URL: https://permmedjournal.ru/0929-8673/article/view/645222
- DOI: https://doi.org/10.2174/0929867330666230607124803
- ID: 645222
Cite item
Full Text
Abstract
Epigenetic mechanisms are crucial in regulating gene expression. These mechanisms include DNA methylation and histone modifications, like methylation, acetylation, and phosphorylation. DNA methylation is associated with gene expression suppression; however, histone methylation can stimulate or repress gene expression depending on the methylation pattern of lysine or arginine residues on histones. These modifications are key factors in mediating the environmental effect on gene expression regulation. Therefore, their aberrant activity is associated with the development of various diseases. The current study aimed to review the significance of DNA and histone methyltransferases and demethylases in developing various conditions, like cardiovascular diseases, myopathies, diabetes, obesity, osteoporosis, cancer, aging, and central nervous system conditions. A better understanding of the epigenetic roles in developing diseases can pave the way for developing novel therapeutic approaches for affected patients.
About the authors
Mohammad Ghanbari
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
Email: info@benthamscience.net
Negin Khosroshahi
Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University
Email: info@benthamscience.net
Maryam Alamdar
Department of Genetics Sciences, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University
Email: info@benthamscience.net
Adel Abdi
Department of Animal Biology, Faculty of Natural Sciences,, University of Tabriz
Email: info@benthamscience.net
Aida Aghazadeh
Department of Animal Biology, Faculty of Natural Sciences,, University of Tabriz
Email: info@benthamscience.net
Mohammad Feizi
Department of Animal Biology, Faculty of Natural Sciences,, University of Tabriz
Email: info@benthamscience.net
Mehdi Haghi
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz
Author for correspondence.
Email: info@benthamscience.net
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