Biomarkers for Diagnosing and Treating Fetal Growth Restriction


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Abstract

Fetal growth restriction (FGR), a common obstetric complication, significantly increases the risks of fetal intrauterine death and neonatal death, and fetuses with growth restriction are prone to cognitive retardation and various diseases in adulthood. The early determination of FGR risk is contentious in clinical research, and few indicators are available for the early prediction and diagnosis of FGR. This review focuses on the prediction and diagnosis of FGR, as well as the significance of biomarkers for FGR, such as those related to gene regulation, apoptosis, mitochondrial function, and inflammation. Although many of these biomarkers are still in the early stages of research, they are good predictors of the threats to fetal health and safety, and they provide new insights for the treatment of FGR.

About the authors

Mengyao Wu

Hubei Key Laboratory of Natural Products Research and Development, Yichang Key Laboratory of Development and Utilization of Health Products with Drug and Food Homology, College of Biology Pharmacy, China Three Gorges University

Email: info@benthamscience.net

Junyu He

Basic Medical College of China Three Gorges University, China Three Gorges University

Email: info@benthamscience.net

Yetao Chen

Hubei Key Laboratory of Natural Products Research and Development, Yichang Key Laboratory of Development and Utilization of Health Products with Drug and Food Homology, College of Biology Pharmacy, China Three Gorges University

Email: info@benthamscience.net

Fangzhu Wan

Hubei Key Laboratory of Natural Products Research and Development, Yichang Key Laboratory of Development and Utilization of Health Products with Drug and Food Homology, College of Biology Pharmacy, China Three Gorges University

Email: info@benthamscience.net

Hongbo Tang

, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital

Email: info@benthamscience.net

Chenghong Yin

, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital

Email: info@benthamscience.net

Haibo He

Hubei Key Laboratory of Natural Products Research and Development, Yichang Key Laboratory of Development and Utilization of Health Products with Drug and Food Homology, College of Biology Pharmacy, China Three Gorges University

Author for correspondence.
Email: info@benthamscience.net

Huifan Yu

College of Biology and Pharmacy, Hubei University of Medicine

Email: info@benthamscience.net

Chengfu Yuan

Basic Medical College of China Three Gorges University, China Three Gorges University

Email: info@benthamscience.net

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