Interleukin-6 Role in Schizophrenia Pathological Mechanisms


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Abstract

It is assumed that schizophrenia may consist of extremely heterogeneous group of phenotypes with different biological and neurochemical pathological mechanisms. At the same time, much attention is paid to the potential role of the immune system in the development of schizophrenia and, in particular, the participation of various cytokines in these processes. Interleukin-6 (IL-6) is one of the key regulators of inflammatory processes. A number of studies have previously reported changes in its levels in patients with schizophrenia. However, data on the specificity of these changes in the literature are much less well-documented and sometimes even contradictory. The dichotomous functioning of IL-6 may play a key role in the regulation of both pro- and anti-inflammatory processes. In this regard, the role of this cytokine in the etiopathogenesis of schizophrenia may depend on the phase of the disease and the context of the inflammatory process. The aim of this review was to analyze in detail the role of IL-6 in the mechanisms of schizophrenia and its potential impact on the course, diagnosis and therapy of this disease.

About the authors

G. V. Rukavishnikov

Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: nchjournal@gmail.com
Russia, Saint-Petersburg

T. V. Zhilyaeva

Bekhterev National Medical Research Center for Psychiatry and Neurology; Privolzhsky Research Medical University

Email: nchjournal@gmail.com
Russia, Saint-Petersburg; Russia, Nizhny Novgorod

E. E. Dubinina

Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: nchjournal@gmail.com
Russia, Saint-Petersburg

G. E. Mazo

Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: nchjournal@gmail.com
Russia, Saint-Petersburg

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Copyright (c) 2023 Г.В. Рукавишников, Т.В. Жиляева, Е.Е. Дубинина, Г.Э. Мазо