Molecular Players at the Sorting Stations of Malaria Parasite ‘Plasmodium falciparum’


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Аннотация

The apicomplexan pathogenic parasite ‘Plasmodium falciparum’ (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures within the iRBCs. The generated structures include knobs and solute ion channels on the erythrocyte surface and specialized organelles i.e. Maurer’s clefts (MCs) in the iRBC cytosol. The above processes are mediated by exporting a large repertoire of proteins to the host cell, most of which are transported via MCs, the sorting stations in parasitized erythrocytes. Information about MC biogenesis and the molecules involved in maintaining MC architecture remains incompletely elucidated. Here, we have compiled a list of experimentally known MC resident proteins, several of which have roles in maintaining its architecture and function. Our short review covers available data on the domain organization, orthologues, topology and specific roles of these proteins. We highlight the current knowledge gaps in our understanding of MCs as crucial organelles involved in parasite biology and disease pathogenesis.

Об авторах

Jasweer Kaur

Department of Biochemistry, Govt. College for Girls, Ludhiana, Punjab, India (Affiliated to Panjab University

Email: info@benthamscience.net

Prakash Mishra

Biotechnology, Guru Nanak Dev University

Email: info@benthamscience.net

Rachna Hora

Department of Molecular Biology and Biochemistry, Guru Nanak Dev University

Автор, ответственный за переписку.
Email: info@benthamscience.net

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