Мақаланы E-mail арқылы жіберу Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles
- Авторлар: Filimonova M.V.1,2, Kolmanovich D.D.3,4, Tikhonowski G.V.2, Petrunya D.S.4,2, Kotelnikova P.A.5, Shitova A.A.1, Soldatova O.V.1, Filimonov A.S.1, Rybachuk V.A.1, Kosachenko A.O.1, Nikolaev K.A.1, Demyashkin G.A.1, Popov A.A.2, Savinov M.S.2, Popov A.L.3,4, Zelepukin I.V.5, Lipengolts A.A.2,6, Shpakova K.E.2,6, Kabashin A.V.7, Koryakin S.N.1,2, Deyev S.M.5, Zavestovskaya I.N.4,2
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Мекемелер:
- National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
- National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
- Aix-Marseille University
- Шығарылым: Том 516, № 1 (2024)
- Беттер: 59-63
- Бөлім: Articles
- URL: https://permmedjournal.ru/2686-7389/article/view/651431
- DOI: https://doi.org/10.31857/S2686738924030104
- EDN: https://elibrary.ru/VTOKHA
- ID: 651431
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
Негізгі сөздер
Толық мәтін
Авторлар туралы
M. Filimonova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre, Obninsk Institute for Nuclear Power Engineering
Ресей, Obninsk; ObninskD. Kolmanovich
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Ресей, Pushchino; Moscow
G. Tikhonowski
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Ресей, Moscow
D. Petrunya
P.N. Lebedev Physical Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Хат алмасуға жауапты Автор.
Email: d.petrunya@lebedev.ru
Ресей, Moscow; Moscow
P. Kotelnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Ресей, Moscow
A. Shitova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskO. Soldatova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskA. Filimonov
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskV. Rybachuk
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskA. Kosachenko
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskK. Nikolaev
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskG. Demyashkin
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Ресей, ObninskA. Popov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Ресей, Moscow
M. Savinov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Ресей, Moscow
A. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Ресей, Pushchino; Moscow
I. Zelepukin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Ресей, Moscow
A. Lipengolts
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
Ресей, Moscow; Moscow
K. Shpakova
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
Ресей, Moscow; Moscow
A. Kabashin
Aix-Marseille University
Email: d.petrunya@lebedev.ru
Франция, Marseille
S. Koryakin
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre, Obninsk Institute for Nuclear Power Engineering
Ресей, Obninsk; ObninskS. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Academician of the RAS
Ресей, MoscowI. Zavestovskaya
P.N. Lebedev Physical Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Ресей, Moscow; Moscow
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