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Joint pain can be caused by injury or disease affecting any of the ligaments, bursae (for example, bursitis), or tendons surrounding the joint. Injury or disease (for example, the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis) can also affect the ligaments, cartilage, and bones within the joint, leading to a painful joint. Pain is also a feature of joint inflammation (arthritis) and infection (for example, Lyme disease) and can be a feature of rare tumors of the joint (for example, pigmented villonodularsynovitis) or chronic fatigue syndrome.

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