PECULIARITIES OF CHRONIC INFLAMMATORY PROCESS IN GASTRIC MUCOSA DEPENDING ON MOLECULAR-GENETIC CHARACTERISTIC OF HELICOBACTER PYLORI IN ADOLESCENTS

Abstract


Aim. To establish the peculiarities of chronic inflammatory process in gastric mucosa depending on molecular-genetic characteristic of Helicobacter pylori ( Hp ) in adolescents. Materials and methods. Endoscopic and morphological examination of 56 adolescents aged 15-18 years with Hp -associated chronic gastroduodenitis was carried out. Genetic typing of Hp was performed in gastrobiopsy material. Results. High frequency (42,86 %) of high-pathogenic Hp strains with detection of VacA, CagA, IceA, BabA and Urel-subunit of urease was stated. Inflammatory process involving Hp with such molecular-genetic characteristics was proved to be well marked and active. The degree of inflammation directly correlates with occurrence of microerosions, hyperplasia foci and morphological signs of initial gastric mucosa atrophy.

About the authors

I S Kormschikov

Email: kormshchikov1983@mail.ru

E M Spivak

Email: spivak58@mail.ru

R M Levit

Email: rlevit@mail.ru

References

  1. Барышникова Н. В. Клинико-микробиологическая характеристика микробиоценоза кишечника и коррекция его нарушений у больных хроническим гастродуоденитом, ассоциированным с Helicobacter pylori: автореф. дис. … канд. мед. наук. СПб., 2006; 3-9.
  2. Ивашкин В. Т., Мегро Ф., Лапина Т. Л. Helicobacter pylori: революция в гастроэнтерологии. М.: Триада Х 1999; 255
  3. Исаков В. А. Молекулярно-генетические основы патогенности Helicobacter pylori. Российский журнал гастроэнтерологии, гепатологии, колонопроктологии 2002; 12: 82-85.
  4. Кораблева Э. В. Клинико-эпидемиологические особенности Helicobacter pylori инфекции у детей и подростков: автореф. дис. … канд. мед. наук. Владивосток 2010; 3-15.

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Copyright (c) 2014 Kormschikov I.S., Spivak E.M., Levit R.M.

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