INSULIN RESISTANCE IN PATIENTS WITH ARTERIAL HYPERTENSION AND CEREBROVASCULAR PATHOLOGY

Aim. To study the peculiar features of carbohydrate metabolism in patients with arterial hypertension (AH) depending on manifestation of cerebrovascular complications. Materials and methods. 38 patients with arterial hypertension associated with type 2 diabetes mellitus (group 1) and 47 patients with arterial hypertension without diabetes (group 2) were examined. Blood glucose, immunoreactive insulin and C-peptide levels were determined in all the examined patients. Insulin resistance was assessed using the design index НOMA and Сaro coefficient. Results. Growth of HOMA index up to 6,31±0,47 in group 1 and 3,18±0,42 in group 2 as well as decrease in C-peptide levels in group1 - by 55,1 %, in group 2 - by 46,9 % was shown. In both groups, HOMA index values were significantly higher in patients with ischemic insult in anamnesis (by 21 and 18 %, respectively; p <0,05). Conclusions. Development of arterial hypertension is accompanied by decline in tissue sensitivity to insulin, impaired synthesis and secretion. Manifestation of disturbances correlates with severity of cerebrovascular complications.

Arterial hypertension, diabetes mellitus, ischemic insult, glucose, insulin, C-peptide, insulin resistance