INSULIN RESISTANCE IN PATIENTS WITH ARTERIAL HYPERTENSION AND CEREBROVASCULAR PATHOLOGY

Abstract

Aim. To study the peculiar features of carbohydrate metabolism in patients with arterial hypertension (AH) depending on manifestation of cerebrovascular complications. Materials and methods. 38 patients with arterial hypertension associated with type 2 diabetes mellitus (group 1) and 47 patients with arterial hypertension without diabetes (group 2) were examined. Blood glucose, immunoreactive insulin and C-peptide levels were determined in all the examined patients. Insulin resistance was assessed using the design index НOMA and Сaro coefficient. Results. Growth of HOMA index up to 6,31±0,47 in group 1 and 3,18±0,42 in group 2 as well as decrease in C-peptide levels in group1 - by 55,1 %, in group 2 - by 46,9 % was shown. In both groups, HOMA index values were significantly higher in patients with ischemic insult in anamnesis (by 21 and 18 %, respectively; p <0,05). Conclusions. Development of arterial hypertension is accompanied by decline in tissue sensitivity to insulin, impaired synthesis and secretion. Manifestation of disturbances correlates with severity of cerebrovascular complications.

References

  1. Дедов И. И., Шестакова М. В. Сахарный диабет и артериальная гипертензия. М: Медицинское информационное агентство 2006; 344.
  2. Ройтберг Г. Е. Метаболический синдром. М.: МЕД-пресс-информ 2007; 224.
  3. Суслина З. А., Гераськина Л. А., Фонякин А.В. Артериальная гипертония, сосудистая патология мозга и антигипертензивное лечение. М. 2006; 200.
  4. Arboix A., Morcillo C., Garcia Eroles L., Massons J., Oliveres M., Targa C. Different vascular risk factor profiles in ischemic stroke subtypes: a study fromthe Sagrat Cor Hospital of Barcelona Stroke Registry. Acta Neurologica Scandinavica 2000; 102: 264-270.
  5. Beckman J. A., Creager M. A., Libby P. Diabetes and Atherosclerosis. Epidemiology, pathophysiology and management. J. Am. Med. Assoc. 2002; 287: 2570-2581.
  6. Bergman R. N. Insulin Resistance: Insulin Action and Its Disturbances in Disease. N. Engl. J. Med. 2005; 353: 2201-2209.
  7. Jellinge P. S. Metabolic consequences of hyperglycemia and insulin resistance. Clinical. Cornerstone 2007; 8: S30-S42.
  8. Zhang X. D., Chen Y. R., Ge L. Features of stroke in Chinese diabetes patients: a hospital-based study. J. Intern. Med. Res. 2007; 35: 540-546.

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Copyright (c) 2014 Novikova L.B., Izhbuldina G.I., Sharipova E.V., Timerbaeva D.A.

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