Aim. To study the peculiar features of carbohydrate metabolism in patients with arterial hypertension (AH) depending on manifestation of cerebrovascular complications. Materials and methods. 38 patients with arterial hypertension associated with type 2 diabetes mellitus (group 1) and 47 patients with arterial hypertension without diabetes (group 2) were examined. Blood glucose, immunoreactive insulin and C-peptide levels were determined in all the examined patients. Insulin resistance was assessed using the design index НOMA and Сaro coefficient. Results. Growth of HOMA index up to 6,31±0,47 in group 1 and 3,18±0,42 in group 2 as well as decrease in C-peptide levels in group1 - by 55,1 %, in group 2 - by 46,9 % was shown. In both groups, HOMA index values were significantly higher in patients with ischemic insult in anamnesis (by 21 and 18 %, respectively; p <0,05). Conclusions. Development of arterial hypertension is accompanied by decline in tissue sensitivity to insulin, impaired synthesis and secretion. Manifestation of disturbances correlates with severity of cerebrovascular complications.


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