Purpose. Studying of correlation of Brain-Derived Neurotrophic Factor (BDNF) level in blood serum and expressiveness of anxiety and depressive symptoms in patients with tension-type headache.

Materials and methods. The research has included 82 patients with tension-type headache. For measurement of BDNF concentration in serum used a method of the enzyme immunodetection - the ELISA Kit test system.

Results. The BDNF level at patients with incidental infrequent and frequent TTH was comparable to group of control. The BDNF level at a chronic tension-type headache was decreased in comparison with the 1st, 2nd group and group of control The BDNF level changes depending on duration and intensity of tension-type headache. 

Conclusions. There is exhaustion not only the mediator, but also neurotrophic systems of a brain at a chronic tension-type headache. Measurement of BDNF concentration in serum will allow to estimate activity of cerebral neuroplasticity processes and to pick up neurotrophic therapy for faster start of serotonin system and knocking over of anxiety and depressive syndrome.