Evaluation of the biliostatic properties of modern topical hemostatic agents used in liver surgery

Cover Page

Abstract


Aim. To evaluate the biliostatic properties of modern topical hemostatic agents used in liver surgery in experiment.

Materials and methods. The analysis of applied topical hemostatics in medical institutions of Chuvash Republic with liver resection is performed. A number of studies on the evaluation of adhesion properties in Vistar rats weighing 180-200 g were carried out using a device for determining the hermeticity of the liver stump by hydroporation. A comparative evaluation of the elasticity and adhesion strength of hemostatic agents was carried out. The polyurethane glue for medical purposes was developed and studied in the experiment.

Results. To prevent bleeding and bile leakage, the most commonly used adhesive compositions are "Bioglue", "Tissucol", a gemostatic sponge, "Tachocomb", a gelatin sponge "Spongostan", a cellulose plate "Sergisel". The adhesive adhesives "Bioglue", "Tissucol" and the hemostatic sponge "Tachocomb" and the polyurethane composition of medical purpose with an adhesive strength of more than 600 mm of water column (mmW) at p <0.05 have the highest adhesion properties at p <0,05, based on the experimental. It has been established that a glue composition "Bioglue" and a polyurethane adhesive composition have a significant adhesive strength (more than 4.6 kgf / cm2) and elasticity (more than 140%).

Conclusions. For the reliable prevention of bile leakage after liver resection, it is necessary to use topical hemostatic agents with an adhesive strength of more than 600 mm. water column. More preferable in this case is the use of adhesive compositions; they have good elasticity, viscosity and form a large area of contact with the bile ducts as compared with the plates and sponges.


Anna Vladimirovna Timoshenkova

Chuvash State University named after I. N.  Ulyanov

Author for correspondence.
Email: colorsit21@mail.ru
ORCID iD: 0000-0002-4672-4544
SPIN-code: 1522-0790

Russian Federation, 428015, Chuvash Republic, Cheboksary city, Moscovsky procpect 15

Graduate student of cathedra surgicals diseases

Mihail Vladimirovich Kuz"min

Chuvash State University named after I. N.  Ulyanov

Email: 6109109@mail.ru
ORCID iD: 0000-0003-3880-9510
SPIN-code: 3703-5110

Russian Federation, 428015 Chuvash Republic, Cheboksary city, Moscovsky procpect 15

PhD of Chemistry

Evgenyi Stepanovich Katanov

Chuvash State University named after I. N.  Ulyanov

Email: katanove@mail.ru
ORCID iD: 0000-0002-1680-3989
SPIN-code: 2132-5435

Russian Federation, 428015 Chuvash Republic, Cheboksary city, Moscovsky procpect 15

Doctor of medical science, Head of department of surgery, oncology with urology

  1. Гальперин Э. И., Чевокин А. Ю., Игнатюк В.Г. Послеоперационные билиарные осложнения при резекциях печени. Хирургия. Журнал им. Н.И. Пирогова. 2011; 1: 12-16.
  2. Давыденко В. В., Власов Т. Д., Доброскок И. Н. Сравнительная эффективность аппликационных гемостатических средств местного действия при остановке экспериментального паренхиматозного и артериального кровотечения. Вестник экспериментальной и клинической хирургии. 2015; 8:186-194.
  3. Заривчацкий В. А., Мугатаров И. Н., Каменских Е. Д., , О. В. Гаврилов О. В., Мальгинов К. Е., Колеватов А. П., Панков К. И. Профилактика и компенсация кровопотери в резекционной хирургии. Пермский медицинский журнал. Пермь 2013; 13 (5): 6-12.
  4. Катанов Е. С., Анюров С. А., Москвичев Е. В., Краснова А. В. Билиарные осложнения после холецистэктомии. Acta medica Eurasica.2016; 1: 14-22.
  5. Краснова А. В. Разработка нового средства для профилактики билиарных осложнений. Отчет о НИР. Чебоксары 2015: 22 .
  6. Патент на изобретение №2583936 «Медицинский клей» от 19.10.2014.
  7. Патент на полезную модель «Устройство для определения герметичности культи печени методом гидропрессии» № 153972 от 29.12.2014.
  8. Тимошенкова А. В., Катанов Е. С., Абызов И. Н., Ворончихин В. В., Анюров С. А. Причины желчеистечений после резекции печени. Практическая медицина. Казань 2016; 5 (97): 53-57.
  9. Халькин А. И., Лисочкин Б. И. Морфологические изменения при склеивании ран печени клеем «циакрин». Оптические квантовые генераторы и полимеры в экспериментальной и клинической хирургии. 1971; 97:112-119.
  10. Чардаров Н. К. Билиарные осложнения после резекции печени. Хирургия.
  11. Журнал им. И.Н.Пирогова. Москва 2010; 8: 61-68.
  12. Штильман М.И. Биоматериалы – важное направление биомедицинских технологий. Вестник РГМУ 2016; 5: 4-14.
  13. Briceño J., Naranjo A., Ciria R. A prospective study of the efficacy of clinical application of a new carrier-bound fibrin sealant after liver resection. Archives of Surgery.2010;145(5):482–486.
  14. Jarnagin W. R., Gonenm M., Fong Y. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Annals of Surgery. 2002; 236(4):397–407.
  15. Nagano Y., Togo S., Tanaka K. Risk factors and management of bile leakage after hepatic resection. World J. Surg. 2003; 27: 695-698.

Supplementary files

There are no supplementary files to display.

Views

Abstract - 85

Cited-By


PlumX

Comments on this article

View all comments

Copyright (c) 2018 Timoshenkova A.V., Kuz"min M.V., Katanov E.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies