CHANGES IN THE STRUCTURE OF THE PROSTATE GLAND OF REPRODUCTIVE-AGE RATS UNDER IMMUNOSUPPRESSION CONDITIONS

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Abstract


The aim of the study was to establish a change in the structure of the prostate gland of experimental animals of reproductive age under conditions of prolonged immunosuppression. The study was carried out on 60 white rats of reproductive age. The state of immunosuppression was modeled using cyclophosphamide at a dosage of 1.5 mg/kg body weight intramuscularly for 10 days. The linear dimensions and volume of the organ were determined. At the microscopic level, the height and width of the epithelial cells, their volume, as well as the larger and smaller diameters and the volume of the cell nuclei were measured. In response to long-term immunosuppressive effects, the organometric parameters of the prostate are decreased both at the early (7, 15 days) and late (30 days) observations due to the direct cytotoxic effect of cyclophosphamide on the glandular-stromal components of the organ. The decrease in the values ​​of linear-volume micromorphometric parameters at the same time of observation confirms the dynamics of the organometric parameters of the gland and indicates an intensive organ response at the micro- and submicroscopic level.


Alexey Alexandrovich Zakharov

SI LPR "St. Luke Lugansk State Medical University"

Author for correspondence.
Email: masterhist@mail.ru
ORCID iD: 0000-0002-7377-2891
SPIN-code: 6551-9091
http://lgmu.ru/index.php/2015-03-16-11-30-02/2015-03-25-13-48-13?id=413"=

Ukraine, Lugansk, 50-years of Lugansk Defence bl., 1g

Candidate of Science (Medicine), Associate professor of histology, cytology and embryology department

Svetlana Arkad'evna Kashchenko

SI LPR "St. Luke Lugansk State Medical University"

Email: masterhist@mail.ru
SPIN-code: 3324-7984

Ukraine, Lugansk, 50-years of Lugansk Defence bl., 1g

Doctor of Science (Medicine), Professor, Head of histology, cytology and embryology department

  1. Директива Европейского Парламента и Совета Европейского Союза по охране животных, используемых в научных целях от 2010 г. № 2010/63/EU / НП «Объединение специалистов по работе с лабораторными животными». Санкт-Петербург 2012; 48 с.
  2. Кащенко С.А., Гончарова М.В. Ультрамикроскопические изменения щитовидной железы крыс после иммуносупрессии. Морфологія 2013; 3: 49-53.
  3. Кирьянов Б.Ф., Токмачев М.С. Математические модели в здравоохранении. В. Новгород: НовГУ им. Ярослава Мудрого 2009; 279 c.
  4. Киселев В.В., Федченко С.Н. Возрастные особенности биометрических характеристик надпочечников белых крыс под действием ксеногенной спинномозговой жидкости. Український морфологічний альманах 2012; 4: 48-50.
  5. Саяпина И.Ю., Целуйко С.С. Долевая специфика ультраструктурной организации простаты крыс в норме и при остром холодовом стрессе. Дальневосточный медицинский журнал 2012; 2: 108-112.
  6. Тишевская Н.В., Максаков Д.А., Головнева Е.С. Морфологические особенности сульпиридной модели доброкачественной гиперплазии предстательной железы у крыс. Экспериментальная и клиническа урология 2017; 2: 16-19.
  7. Шерстюк О.А. Роль анатомических знаний в диагностике и лечении заболеваний простаты. Вiсник проблем бiологii i медицини 2013; 3: 56-61.
  8. Grabowska M., Kędzierska K., Michałek K. Effects of an immunosuppressive treatment on the rat prostate. Drug Design, Development and Therapy 2016; 10: 2899-2915.
  9. Hamid Reza Moradi, Naeem Erfani Majd, Saleh Esmaeilzadeh, Sayed Reza Fatemi Tabatabaei. The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia. Vet Res Forum 2015; 6 (1): 23-29.
  10. Jivrajani M., Vaseem Shaikh M., Shrivastava N., Nivsarkar M. An improved and versatile immunosuppression protocol for the development of tumor xenograft in mice. Anticancer Research 2014; 34: 7177-7184.
  11. Nagorniy M.A., Kashchenko S.A. The morphostructure of lymphoid organs and hypophysis of experimental animals after immunotropic influences. Український медичний альманах 2012; 1, додаток: 53-54.

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Copyright (c) 2018 Zakharov A.A., Kashchenko S.A.

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