EFFICIENCY ASSESSMENT OF ANTITUBERCULOUS VACCINE IN CHILDREN WITH ATOPIC DERMATITIS

Aim. To determine the peculiarities of skin reaction course at the site of BCG vaccine administration and mechanisms of development of postvaccinal tuberculin allergy in children with moderate atopic dermatitis (AtD). Materials and methods. In 92 children with atopic dermatitis of medium degree of severity and 166 healthy children vaccinated BCG on the 3-5 days of life, efficiency of vaccination at the site of vaccine administration (character, diameter of skin signs) by skin reaction in 1,5-2, 3-4, 5-9 months, 1, 2, 3 years after immunization as well as tuberculin sensitivity by Mantoux test with 2 TE PPD-L in 1, 2, 3 years after vaccination were assessed. Results. It was established that manifestation of disease in 95,7 % of children with AtD coincides with development of skin reaction at the site of BCG administration with the following peculiar features: delayed start, more frequent formation of pustule in the period of infiltration, slower healing of affect and formation of a scar of lesser diameter than in healthy children. Among AtD children, the postvaccinal allergy was revealed with equal frequency in 1 (78 %), 2 (77,3 %) and 3 (72,8 %) years; in 1 and 2 years after vaccination it was less marked than in healthy children. In 3 years after vaccination, there was a twofold growth in the number of negative reactions by Mantoux test among healthy children. Conclusions. Efficiency of BCG vaccination in children with Atd determined by the size of scar in 1 year after immunization and tuberculin sensitivity with 2TE PPD-L occurred to be lower than in healthy children.

Atopic dermatitis, BCG vaccination, local skin reaction, Mantoux test with 2 TE PPD-L