Role of acute phase proteins in diagnosis of uremic pancreatitis and destructive pancreatitis in patients receiving renal replacement therapy (programmed hemodialysis)

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Objective. To determine the blood serum β2-microglobulin and α2-macroglobulin concentration in patients undergoing renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pancreatitis and / or destructive pancreatitis.

Materials and methods. The study involved 52 patients admitted to the Surgical Unit of Astrakhan "RZhD-Medicine" Hospital and City Clinical Hospital № 3. The blood serum β2-microglobulin and α2-macroglobulin concentration was analyzed in patients admitted on an emergency basis with suspicion of uremic pancreatitis and destructive pancreatitis, who receive renal replacement therapy (programmed hemodialysis). The control group included 50 outpatients undergoing renal replacement therapy (programmed hemodialysis). The study did not include patients with suspected pancreatitis who were not receiving renal replacement therapy. The period of the study is 2019–2021.

Results. The concentration of blood serum β2-microglobulin is statistically higher than normal in all patients, who had received renal replacement therapy (programmed hemodialysis) in anamnesis. The most statistically high concentration of β2-microglobulin was revealed while studying patients with uremic pancreatitis (n = 34), and was (30.0 ± 2.75 mg/l) compared with the blood serum concentration in patients with destructive pancreatitis (8 ± 0.51 mg / l). The concentration of α2-macroglobulin was statistically lower in destructive pancreatitis (n = 18) and was 615 ± 161 mg/l compared with uremic pancreatitis (980 ± 216 mg/l). In the control group of outpatients (n = 50) receiving renal replacement therapy (programmed hemodialysis), no statistically significant blood serum concentrations of β2-microglobulin and α2-macroglobulin were found.

Conclusions. A clear dependence of the concentration of β2-microglobulin and α2-macroglobulin on the severity of uremic pancreatitis and destructive pancreatitis was established. Statistically high values of β2-microglobulin concentrations were obtained in patients with uremic pancreatitis, and the α2-macroglobulin level was statistically low in destructive pancreatitis.

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The purpose of the study. Determination of β2-microglobulin and lactoferrin concentration in blood serum in patients on  renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pseudoperitonitis and peritonitis.

Materials and methods. We examined 56 patients admitted to the surgical department of the hospital RZD-Medicine and the City Clinical Hospital no. 3 in Astrakhan, and the concentration of β2-microglobulin and lactoferrin in the blood serum of patients admitted on an emergency basis with suspicion of uremic pseudoperitonitis or peritonitis, who receive renal replacement therapy (programmed hemodialysis). The control group included 50 outpatients on renal replacement therapy (programmed hemodialysis). The study did not include patients with suspected peritonitis who did not receive renal replacement therapy (programmed hemodialysis). The period of the study is 2019-2021.

Results. The concentration of serum β2-microglobulin is statistically higher than normal in all patients receiving renal replacement therapy (programmed hemodialysis) in history. The most statistically high concentration of β2-microglobulin was detected in a study in patients with uremic pseudoperitonitis (n = 39), and was (30,000 ± 6680 ng / ml), compared with the concentration in serum in patients with peritonitis (6000 ± 519.9 ng / ml). The concentration of lactoferrin is statistically high in peritonitis (n = 17) and was (3480 ± 439 ng / ml), compared with uremic pseudoperitonitis (1160 ± 148 ng / ml). In the control group of outpatients (n = 50) receiving renal replacement therapy (programmed hemodialysis), statistically significant serum concentrations of β2-microglobulin and lactoferrin were not detected.

Conclusions. A clear dependence of the concentration of β2-microglobulin and lactoferrin on the severity of uremic pseudoperitonitis and peritonitis was established. Statistically high values ​​of β2-microglobulin concentration were obtained in patients with uremic pseudoperitonitis, and the level of lactoferrin was statistically high in peritonitis.

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About the authors

Kazim G. Gasanov

Astrakhan State Medical University

Author for correspondence.
Email: nazim.gasanov.1985@mail.ru

postgraduate student, Department of Surgical Diseases of Pediatric Faculty

Russian Federation, Astrakhan

Viktor A. Zurnadzhyants

Astrakhan State Medical University

Email: zurviktor@yandex.ru

MD, PhD, Professor, Head of Department of Surgical Diseases of Pediatric Faculty

Russian Federation, Astrakhan

Eldar A. Kchibekov

Astrakhan State Medical University

Email: Eidar_76@inbox.ru

MD, PhD, Professor, Department of Surgical Diseases of Pediatric Faculty

Russian Federation, Astrakhan

M. I. Shikhragimov

Astrakhan State Medical University

Email: nazim.gasanov.1985@mail.ru

Assistant, Department of Surgical Diseases of Pediatric Faculty

Russian Federation, Astrakhan

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Copyright (c) 2021 Gasanov K.G., Zurnadzhyants V.A., Kchibekov E.A., Shikhragimov M.I.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 70264 от 13.07.2017 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 75489 от 05.04.2019 г.


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