ISOSORBIDE DINITRATE EFFECT ON HEART RATE VARIABILITY, DISTURBED RHYTHM AND CONDUCTIVITY IN PATIENTS WITH STABLE FUNCTIONAL CLASS 1 AND 2 STENOCARDIA ASSOCIATED WITH HYPERTENSIVE DISEASE


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Abstract

Aim. To improve the results of treatment of patients with nonparasitic hepatic cysts and to determine optimal treatment technique depending on concomitant pathology, terms of hospitalization, number of relapses and postoperative complications. Aim. To study the effect of isosorbide dinitrate (ISDN) on heart rate variability (HRV) in patients with stable functional class (FC) 1 and 2 stenocardia (St) associated with hypertensive disease (HD). Materials and methods. 194 patients with FC 1 and 2 St HD (mean age 54,5±5,2) were examined. Along with standard methods of investigation, high resolution rhythmocardiography (RCG) using diagnostic complex KAP-RK-01-“Micor” (T.F. Mironova, V.A. Mironov, Chelyabinsk, Registration Certificate №FS 02262005/2447.06) with temporary and spectral analysis of sinus heart rhythm (SHR) wave structure was applied. Results. Under the effect of ISDN, patients with Fc 1 and 2 St HD had significant rise in general heart rate variability (SDNN). Together with such shifts, there is growth of humoral-metabolic spectral characteristics (VLF%) – reliable in the background test ( p <0,05), tendency to increase in sympathetic (LF%) with fall in parasympathetic (HF%) – significant in the background test ( p <0,0001), Valsalva ( p <0,01) and Ashner ( p <0,0001) tests, with physical load – PWC 120 ( p <0,05). Arythmogenic effect of the investigated nitrovasodilator manifested by growth of ventricular and supraventricular extrasystoles, migration of auricle pacemaker, development of synoatrial node was observed. Conclusion. The method of rhythmocardiography helps to choose an antianginal therapy and predicts side effects of organic nitrates.

Full Text

Воздействие изосорбида динитрата на вариабельность сердечного ритма, нарушения ритма и проводимости у пациентов со стабильной стенокардией 1-го и 2-го функциональных классов с сопутствующей гипертонической болезнью
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About the authors

E A Safronova

Email: safronova68@rambler.ru

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