THE POSSIBILITY OF USING THE MELD SCALE FOR DETERMINING SEVERITY OF LIVER CIRRHOSISTHE

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Abstract

Objective: to Study the possibility of using the MELD scale to determine the severity of CKD and to determine its diagnostic capabilities.
Methods:we Examined 30 patients with CKD, of which 15 patients were compensated stage of CKD (grade a+) Child-Pugh and 15 people with decompensated cirrhosis (class C). In the blood was evaluated the concentration of total bilirubin and creatinine were calculated INR and the MELD index.
Results: the Calculated MELD index using the indicators of total bilirubin, creatinine and INR increased with the progression of CKD 5 in the stage of compensation to 26 in decompensated stage (p<0.001) and directly correlated with the severity of cirrhosis, assessed by Child-Pugh (rs=0,64; p=0.005). The threshold index value of MELD for the differentiation of compensated stage decompensated CPU from equal to 11.
Conclusions:MELD Calculated index allows to differentiate the degree of severity of CKD with a sensitivity of 73.3% and a specificity of 84.6%. When the value of the index, MELD less than or equal to 11 are diagnosed with compensated stage of the CPU, a value of more than 11 sets of decompensated cirrhosis.Ваши исправления помогают повысить качество машинного переводаСообщить об ошибке

About the authors

Irina Bulatova

Email: bula.1977@mail.ru

Svetlana Paducheva

Пермский государственный медицинский университет

Author for correspondence.
Email: paducheva_sv@mail.ru
ORCID iD: 0000-0001-8255-088X
SPIN-code: 2581-7279
https://elibrary.ru/author_profile.asp?id=953430

ассистент кафедры клиническая лабораторная диагнстика ФДПО

Russian Federation

Alevtina Shchekotova

Email: al_shchekotova@mail.ru

Irina Shchekotova

Email: shchekotirina@mail.ru

References

  1. Бессонова Е.Н., Кокина К. Ю. Современные возможности оценки тяжести состояния и прогноза жизни больных циррозом печени в терминальной стадии. Клинические перспективы гастроэнтерологии, гепатологии. 2012; 5: 19-26.
  2. Власов В. В. Эффективность диагностических исследований. М.: Медицина 1988; 256.
  3. Краснов О.А., Павленко В.В., Краснов К.А., Краснов А.О., Пельц В.А., Старцев А.Б., Аминов И.Х., Сохарев А.С., Керопян С.Е. Современные методы оценки функционального резерва печени в резекуионной хирургии органаю Медицина и образование в Сибири. 2014; 6: http://www.ngmu.ru/cozo/mos/article/text_full.php?id=1603].
  4. Кучерявый Ю.А., Стукова Н.Ю., Ахтаева М.Л. Хронический гепатит, цирроз печени и гепатоцеллюлярная карцинома - звенья одной цепи. Клинические перспективы гастраэнтерологии и гепатологии. 2012; 5: 3-12.
  5. Лечение осложнений цирроза печени (методические рекомендации для врачей). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2009; 1(19): 78-86.
  6. Тайшин Д.О., Солдатова Г.С. Анализ прогностических шкал для оценки исхода цирроза печени. Вестник НГУ. Серия: Биология, клиническая медицина. 2014; 2(12).
  7. Flodén A. Calculation and comparison of the model for end-stage liver disease (MELD) score in patients accepted for liver transplantation in 1999 and 2004. Transplant Proc. 2007; 39: 385–386.
  8. Huo T.I. The sequential changes of the model for end-stage liver disease score correlate with the severity of liver cirrhosis in patients with hepatocellular carcinoma undergoing locoregional therapy. J Clin Gastroenterol. 2006; 40(6): 543-50.
  9. Kamath P.S., Wiesner R.H., Malinchoc M. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001; 33(2): 464–70.
  10. Lucey M.R., Brown K.A., Everson G.T. Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases. Transplantation. 1998; 66 (7): 956–62.

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Copyright (c) 2018 Bulatova I., Paducheva S., Shchekotova A., Shchekotova I.

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